Recombinant Arabidopsis thaliana Retinoblastoma-related protein 1 (RBR1), partial

1. XND1 harbors an apparently angiosperm-specific combination of interaction motifs potentially linking the general differentiation regulator RBR with a xylem-specific pathway for inhibition of differentiation. PMID: 28742236
2. One function of RBR1 is the direct repression of the stem cell factor WUSCHEL (WUS), which ectopically accumulates in meiocytes of triple krp and rbr1 mutants. PMID: 28450583
3. The authors find that RBR1 is also required for RAD51 localization to DNA lesions. PMID: 28320735
4. Together with E2FA, RBR is directly involved in the transcriptional DNA damage response as well as in the cell death pathway that is independent of SOG1, the plant functional analogue of p53. PMID: 28320736
5. SIM and SMR1 are involved in hyperphosphorylation of the cell-cycle regulator RBR1 and overexpression of E2F target genes. PMID: 25455564
6. Irreversible cell fate commitment in the Arabidopsis stomatal lineage requires a FAMA and RBR interaction. PMID: 25303364
7. RBR protein stimulates cell differentiation in the Arabidopsis root meristem by interacting with cytokinin signaling. PMID: 24285791
8. RBR is important in early leaf development and the extent to which physiology adapts to modified cellular architecture resulting from altered cell-cycle gene expression. PMID: 24118480
9. RBR interacts with the stem cell transcription factor SCARECROW (SCR) through an LxCxE motif. PMID: 24302889
10. S6K1 interacts with RBR via its N-terminal RBR binding motif, promotes its nuclear localization and consequent RBR-dependent repression of cell cycle genes through E2FB. PMID: 23531690
11. RBR1 regulates not only cell cycle genes, but also, independent of the cell cycle transcription factor E2F, genes required for formative divisions and cell fate acquisition, thus directly linking cell proliferation with differentiation. PMID: 23104828
12. Study tissue-generating asymmetric divisions in a stem cell daughter within the Arabidopsis root finds spatial restriction of these divisions requires physical binding of the stem cell regulator SCARECROW (SCR) by the RETINOBLASTOMA-RELATED (RBR) protein. PMID: 22921914
13. AtRBR1 undergo proteasome-dependent degradation during sucrose starvation in Arabidopsis PMID: 22019639
14. Data show that RBR has unique cell-autonomous functions in different cell types within the root stem cell niche. PMID: 21742994
15. RBR is a positive regulator of the developmental switch from embryonic heterotrophic growth to autotrophic growth. PMID: 21693514
16. Retinoblastoma protein is essential for early meiotic events in Arabidopsis. PMID: 21217641
17. Conditional downregulation and loss of RBR function uncouples division and differentiation of meristemoid cells in leaves and disrupts the appropriate division and maintenance of meristem stem cells. PMID: 20525851
18. RBR restricts cell division early during leaf development when cell proliferation predominates, while it regulates endocycle occurrence at later stages. PMID: 16361519
19. This research shows that if there is a local reduction of the Retinoblastoma-Related Gene (RBR) in the roots of Arabidopsis roots this increases the amount of stem cells without affecting the cell cycle. PMID: 16377572
20. EBP1 is a conserved, dose-dependent regulator of cell growth that is connected to meristematic competence and cell proliferation via regulation of RBR1 level. PMID: 17024182
21. Results show that confirmed that downregulation of AtRBR1 leads to a prolonged G2 phase and delayed activation of G2/M marker genes. PMID: 18064404
22. We have thus identified a new mechanism required for imprinting establishment, outlining a new role for the Retinoblastoma pathway, which may be conserved in mammals. PMID: 18700816
23. RBR1 is required for cell differentiation of male and female gametophytes. PMID: 18976913

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KEGG: ath:AT3G12280

STRING: 3702.AT3G12280.1

UniGene: At.14958