Recombinant Bovine Kappa-casein (CSN3)

1. The influence of CSN3 genotype on milk production and chemical composition in Romanian Simmental cattle PMID: 28850632
2. It was concluded that GH or IGF-I can independently promote the expression of CSN3 in bovine mammary epithelial cells in vitro. PMID: 26173981
3. Statistical analysis established that the CSN3 gene has no statistically significant influence on daily milk, fat and protein yield and SCC PMID: 22614274
4. Effects of beta-kappa-casein (CSN2-CSN3) haplotypes and BLG genotypes on yields were weak or trivial. PMID: 20655450
5. the propensity of the disulfide-linked multimers to form fibrils is inversely related to their size, with monomeric kappa-casein being the most aggregation prone PMID: 20441567
6. molecular dynamics simulation of bovine chymosin complexed with the P9-P70 residues of bovine kappa-casein PMID: 20155951
7. Phe-Leu-Pro-Tyr-Pro-Tyr (FLPYPY), corresponding to peptidic sequence 76-81 of bovine kappa-casein, exhibits neurite outgrowth-stimulating activity over 10(-9) M PMID: 15618646
8. The recombinant Caseinomacropeptide (hCMP)has been produced as a secretory product in yeast and was estimated to be 7.0kDa by SDS-PAGE, and showed a lower glycosylation than the natural bovine CMP. PMID: 15866733
9. Findings suggest that alphaS- and beta-casein are potent inhibitors of kappa-casein fibril formation and may prevent large-scale fibril formation in vivo. PMID: 16363816
10. kappa-casein gene (CSN3) promoter regions of cattle of different breeds revealed that 2 distinct haplotypes (A and B) exist at this locus with A allele dominant in all groups and B allele more representative of promoters from other ruminants PMID: 17699026
11. The effect of lactoferrin on beta-casein and kappa-casein mRNA expression in mammospheres while silencing of LTF increased casein mRNA expression. PMID: 18226297
12. In heterozygotes, beta-casein A and beta-lactoglobulin A were found at higher concentrations in milk compared with the variant encoded by the alternative allele whereas kappa-casein A and B variants were found at similar concentrations in AB heterozygotes PMID: 18363977
13. These findings suggest a model of aggregation during which the S-carboxymethylated kappa-casein monomer is in rapid equilibrium with a micellar aggregate that subsequently undergoes a conformational rearrangement into a more organized species. PMID: 18616951
14. The frequencies of the B allele of kappa-casein among breeds ranged from 0.01 to 0.30; the Sindhi breed had the highest frequency for the B allele (0.30), while the frequencies of this allele in other breeds ranged from 0.01 to 0.18. PMID: 18752189
15. Six single nucleotide polymorphisms were identified and haplotype inference revealed 12 haplotypes, of which 8 were newly discovered PMID: 18765626

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KEGG: bta:281728

STRING: 9913.ENSBTAP00000028685

UniGene: Bt.49421