Recombinant Chicken BDNF/NT-3 growth factors receptor(NTRK2),partial

Code CSB-YP845939CH
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Source Yeast
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Code CSB-EP845939CH
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Source E.coli
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Code CSB-EP845939CH-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP845939CH
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Source Baculovirus
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Code CSB-MP845939CH
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Source Mammalian cell
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Product Details

Purity >85% (SDS-PAGE)
Target Names NTRK2
Uniprot No. Q91987
Alternative Names NTRK2; TRKB; BDNF/NT-3 growth factors receptor; EC 2.7.10.1; Neurotrophic tyrosine kinase receptor type 2; TrkB tyrosine kinase; Trk-B
Species Gallus gallus (Chicken)
Protein Length Partial
Tag Info The following tags are available.
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting
and FAQs
Protein FAQs
Storage Condition Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet Please contact us to get it.

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Target Background

Function
Receptor tyrosine kinase involved in the development and the maturation of the central and the peripheral nervous systems through regulation of neuron survival, proliferation, migration, differentiation, and synapse formation and plasticity. Receptor for BDNF/brain-derived neurotrophic factor and NTF4/neurotrophin-4. Alternatively can also bind NTF3/neurotrophin-3 which is less efficient in activating the receptor but regulates neuron survival through NTRK2. Upon ligand-binding, undergoes homodimerization, autophosphorylation and activation. Recruits, phosphorylates and/or activates several downstream effectors including SHC1, FRS2, SH2B1, SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades. Through SHC1, FRS2, SH2B1, SH2B2 activates the GRB2-Ras-MAPK cascade that regulates for instance neuronal differentiation including neurite outgrowth. Through the same effectors controls the Ras-PI3 kinase-AKT1 signaling cascade that mainly regulates growth and survival. Through PLCG1 and the downstream protein kinase C-regulated pathways controls synaptic plasticity. Thereby, plays a role in learning and memory by regulating both short term synaptic function and long-term potentiation. PLCG1 also leads to NF-Kappa-B activation and the transcription of genes involved in cell survival. Hence, it is able to suppress anoikis, the apoptosis resulting from loss of cell-matrix interactions. May also play a role in neutrophin-dependent calcium signaling in glial cells and mediate communication between neurons and glia.
Gene References into Functions
  1. BDNF released by preganglionic axons acts chemotactically on TrkB-positive sympathetic neurons, to pattern the developing peripheral nervous system. PMID: 26404565
  2. Cessation of TrkB expression is essential for dendrite retraction and functional maturation of nucleus magnocellularis neurons. PMID: 23035107
  3. These results suggest that BDNF promotes the induction of imprinting through TrkB exclusively during the critical period. PMID: 23094873
  4. Activation of BDNF/TrkB signaling in the intermediate medial hyperpallium apicale is not involved in memory acquisition in filial imprinting in newly hatched chicks. PMID: 22015740
  5. findings demonstrate roles for BDNF-induced, trk-dependent signaling in ciliary ganglion neurons, both in regulating expression of alpha7-nAChRs and in enhancing transmission at alpha3*-nAChR-mediated synapses PMID: 15128848
  6. elevated BDNF expression above basal levels and signaling through TrkB in sympathoblasts may be a mechanism that contributes to the onset of neuroblastoma PMID: 17309801
  7. The ephrinA/TrkB Interaction is neurotrophin induced and specifically augments the PI-3 kinase/Akt pathway generally known to be involved in the promotion of branching. PMID: 19036963

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Subcellular Location Cell membrane; Single-pass type I membrane protein. Endosome membrane; Single-pass type I membrane protein. Cell projection, axon. Cell projection, dendrite. Cytoplasm, perinuclear region. Cell junction, synapse, postsynaptic density.
Protein Families Protein kinase superfamily, Tyr protein kinase family, Insulin receptor subfamily
Tissue Specificity Detected in embryonic brain and orsal root ganglia.
Database Links

KEGG: gga:396157

STRING: 9031.ENSGALP00000020539

UniGene: Gga.681

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