Recombinant Danio rerio Sonic hedgehog protein A (shha)

1. Mutation of hmgcs1 had no effect on Shh signaling at 2 and 3 days post fertilization (dpf), but did result in a decrease in the expression of gli1, a known Shh target gene, at 4 dpf, after morphological deficits in craniofacial development and chondrocyte differentiation were observed in hmgcs1 mutants. PMID: 28686747
2. Shha/Smo is functionally dedicated to ray branching during fin regeneration. PMID: 28351866
3. Shh and Rx3 govern formation of a distinct progenitor domain that elaborates patterning through its anisotropic growth and differentiation. PMID: 27317806
4. Time-lapse imaging revealed that knockdown of miR-219 function accelerates the growth of primary cilia, revealing a possible mechanistic link between miR-219-mediated regulation of apical Par proteins and Shh signaling. PMID: 27226318
5. Shh is not essential for the early activation of has2, but supports proper chondrogenic differentiation. PMID: 27060628
6. Opposing Shh and Fgf signals initiate nasotemporal patterning of the zebrafish retina. PMID: 26428010
7. Hedgehog signaling has a role in dental papilla formation and tooth size during zebrafish odontogenesis PMID: 25645398
8. Data indicate that the transgenic lines report Hedgehog pathway state in individual cells and with high sensitivity. PMID: 25068273
9. We further demonstrate that the elevated Hedgehog signaling in Sox11-deficient zebrafish was caused by a large increase in shha transcription; indeed, suppressing Shha expression rescued the ocular phenotypes of sox11 morphants. PMID: 25010521
10. Pax6 has an evolutionarily conserved function in establishing the temporospatial expression of Shh in the mid-diencephalic organizer in vertebrates. PMID: 24528677
11. Sulf1 triggers Shh signaling activity to establish and, later on, modify the spatial arrangement of gene expression in ventral neural progenitors PMID: 24595292
12. These studies provide evidence that a signaling pathway involving agrin, Fgfs and Shh may be a critical target of ethanol exposure during zebrafish embryogenesis. PMID: 23184466
13. heterozygote mutations in fgf8, shh or oep lead to a reduced number of ascending dopaminergic neurons in zebrafish and may confer increased susceptibility to the Parkinson disease PMID: 23123778
14. Hh is able to bypass VEGF to induce arterial differentiation in ECs via the calcitonin receptor-like receptor, thus revealing a surprising complexity in the interplay between Hh and VEGF signaling during arteriovenous specification. PMID: 22668851
15. analysis of Hh signaling which induces pancreatic fibrosis through paracrine activation of Hh-responsive cells in vivo PMID: 22164219
16. The present study investigates the role of the shha-expressing cells in the patterning of fin ray branches. PMID: 22445510
17. The Sphingosine-1-phospate-dependent anterior foregut endoderm functions primarily through Shh to regulate the growth but not dorsoventral patterning of zebrafish jaw precursors. PMID: 22185793
18. function for Bhmt involving modulation of Shh signaling to control beta-cell development. PMID: 21952238
19. Hedgehog and retinoic acid signaling cooperate to promote motoneurogenesis in zebrafish. PMID: 22069185
20. Microphthalmia produced by combined agrin MO and ethanol treatment was rescued by sonic hedgehog (Shh) mRNA overexpression. PMID: 21308976
21. role of Shh signalling in patterning the pharyngeal pouches and in restricting the expression of the parathyroid marker Gcm2 in the pharyngeal epithelium PMID: 21349263
22. Data show that inhibiting or eliminating hedgehog (Hh) signaling reduces neural progenitor cell proliferation affecting neurogenesis in the optic tectum. PMID: 21219478
23. IP6K2 is a positive regulator of Hh signaling. PMID: 20980661
24. Hh signaling is indirectly required via slow fiber specification for recovery of fast fiber elongation in laminin gamma1 mutant embryos PMID: 20063418
25. fish-specific duplicated dmrt2b contributes to a divergent function in somitogenesis through Hedgehog pathway and maintains the common function for left-right asymmetry establishment PMID: 19789708
26. There exists cooperation between Nodal and Hedgehog pathways in the maintenance of the anterior-dorsal hypothalamus. PMID: 12070082
27. Involved in anteroposterior patterning of the zebrafish otic vesicle. PMID: 12588855
28. roles of signaling in pituitary development PMID: 12606279
29. role in adenohypophysis formation PMID: 12606280
30. extraretinal and retinal hedgehog signaling sequentially regulate retinal differentiation PMID: 12798293
31. Our results do not support the previously suggested dominant roles for sonic hedgehog and Fgf8 in specification of the first catecholaminergic neurons, but instead indicate a novel role for Nodal signaling in this process PMID: 12843251
32. Disp1 activity is essential for the secretion of lipid-modified Hh proteins from midline structures. PMID: 15110707
33. Igu/Dzip1 functions as a permissive factor that is required for the proper regulation of Hh target genes in response to Hh signals. PMID: 15115751
34. hdac1-deficient embryos exhibit several defects of neuronal specification and patterning, including a dramatic deficit of hedgehog-dependent branchiomotor neurones that is refractory to elevated levels of hedgehog signalling. PMID: 15169759
35. Directs differentiation of inner and outer nuclear layers of retina, also lamination of retina. PMID: 15253932
36. Shh expression was studied in developing zebrafish. PMID: 15272389
37. Some multipotent muscle precursors' commitment to the slow fate depends on Hedgehog. PMID: 15464578
38. spatial and temporal differences in Hh signaling within a common population of neural precursors can contribute to cell fate diversification PMID: 15539490
39. gli2b expression is affected in Hedgehog and Notch signaling related mutants during zebrafish embryonic development PMID: 15614761
40. results suggest that a functional interaction between beta-arrestin 2 and Smoothened may be critical to regulate hedgehog signaling in zebrafish development PMID: 15618520
41. Shh directs cell-cycle exit by activating p57Kip2 in the developing zebrafish retina. PMID: 15891769
42. results suggest a novel role for Shh in the movements of neural crest cells at the midline, as well as in their differentiation into cartilage PMID: 16049113
43. Expression of IHH and downstream targets correlates with pit cells. IHH and SMO may be useful biomarkers of diffuse cancers that may show growth inhibition with Hh antagonists such as cyclopamine. PMID: 16831586
44. Zebra fish foxl1 is a novel regulator of neural development that acts by suppressing shh expression. PMID: 16980626
45. pattern of shh expression in the embryonic central nervous system involves an intricate crosstalk of at least 4 different regulatory regions PMID: 17157288
46. Results suggest that Hedgehog proteins can regulate skeletal appendage outgrowth and demonstrates an unexpected mechanism for mediating Shh signals in a median fin primordium. PMID: 17597528
47. Data show that endoderm and hedgehog signaling, but not Hand2, regulate GDNF expression in the intestine, highlighting a central role of endoderm and Sonic hedgehog in patterning the intestine and the enteric nervous system. PMID: 18436202
48. Expression of multiple slow myosin heavy chain genes reveals a diversity of zebrafish slow muscle twitch fibers with differing requirements for shh and Prdm1 activity. PMID: 18480160
49. These results identify Six3 as a direct regulator of Shh expression and reveal a crossregulatory loop between Shh and Six3 in the ventral forebrain. PMID: 18694563
50. addition of exogenous Shh to ethanol treated zebrafish prevented many of the gross physical phenotypes, suggesting that the suppression of Shh-s is one of the major effects of ethanol exposure. PMID: 19235835

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KEGG: dre:30269

STRING: 7955.ENSDARP00000125090

UniGene: Dr.115833