Recombinant Drosophila melanogaster C-terminal-binding protein (CtBP)

1. We found that TCF7L1 recruits the C-terminal binding protein (CtBP) and histone deacetylase 1 (HDAC1) to the DKK4 promoter to repress DKK4 gene expression. In the absence of TCF7L1, TCF7L2 and beta-catenin occupancy at the DKK4 promoter is stimulated and DKK4 expression is increased. These findings uncover a critical role for TCF7L1 in repressing DKK4 gene expression to promote the oncogenic potential of CRCs. PMID: 28450117
2. These results support a model where CtBP is a gene-specific regulator of Wingless signalling, with some targets requiring CtBP dimers for inhibition while other targets utilize CtBP monomers for activation of their expression. PMID: 21468031
3. Results indicate that the structural and enzymatic features of C-terminal binding protein are critical for modulating this protein's activity in diverse developmental settings. PMID: 21078873
4. CtBp proteins repress transcription in a histone deacetylase-dependent or independent manner. PMID: 11864595
5. Reduction of dCtBP function enhances H mutant phenotypes and suppresses N phenotypes in the adult mechanosensory bristle. This activity of gro is surprising, because it is directed oppositely to its traditionally defined role as a neurogenic gene. PMID: 12154126
6. YY1 protein and Polycomb group (PcG) protein require this repressor protein for repression in vivo. PMID: 12628927
7. These findings provide evidence that competition is distinct from quenching and direct repression; quenching and direct repression depend on CtBP, whereas competition does not. PMID: 12748300
8. Functional similarity of Knirps CtBP-dependent and CtBP-independent transcriptional repressor activities. PMID: 12888527
9. CtBP contributes quantitatively, rather than qualitatively, to overall repression function. PMID: 15128671
10. requirement for Gro and CtBP in Hairless-mediated repression PMID: 16287856
11. Here, we discuss the cytoplasmic roles of the CtBPs and the possible mechanisms that enable them to switch between cell compartments and multiple functions. PMID: 16483777
12. AChE's 3' alternative splicing, and the corresponding changes in AChE-S/CtBP interactions, thus emerge as being actively involved in controlling hematopoiesis PMID: 17476278
13. the ancestral dehydrogenase activity is not required for CtBP function, and NAD binding may play a regulatory, rather than catalytic, role PMID: 17964573
14. These data, taken together, suggest that AN is functionally distinct from dCtBP. PMID: 17972097
15. dCtBP is part of a gene circuitry that controls the patterning and differentiation of the fly peripheral nervous system via multiple mechanisms PMID: 18992810

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KEGG: dme:Dmel_CG7583

STRING: 7227.FBpp0099514

UniGene: Dm.2246