Recombinant Drosophila melanogaster Ecdysone receptor (EcR), partial

1. study identifies a non-canonical EcR-corepressor complex with the potential for a direct regulation of ATP-dependent nucleosome remodelling by a nuclear hormone receptor PMID: 28378812
2. Results shows that ectopic overexpression of mir34 downregulates EcR in mushroom body (MB) neurons suggesting that EcR expression may be under the regulation of mir34 in drosophila. PMID: 28008974
3. The ecdysone receptor (EcR), which is responsible for initiating the larval-to-adult transition, colocalized with 14-3-3epsilon in wild-type fat body tissues. PMID: 28365999
4. Polytene chromosome stains showed that Cg co-localizes with EcR, the major regulator of BR-C, at the BR-C locus and that EcR binding to chromatin was sensitive to changes in Cg levels PMID: 27846223
5. Data show that ecdysone receptors EcRA and EcRB1 are expressed by third instar larvae in the primary nociceptor neurons. PMID: 26495837
6. CDK8-CycC may serve as transcriptional cofactors for EcR-dependent transcription. PMID: 26222308
7. E75 and ecdysone receptor are expressed in central clock cells, and manipulations of their expression produce drastic effects on circadian rhythms in Drosophila. PMID: 25511299
8. Expression levels of estrogen-related receptor gene (ERR), ecdysone receptor gene (EcR) and Yolk protein receptor gene (YPR) were significantly changed by ethylparaben treatment. Female fruit flies are more sensitive to EP than males. PMID: 25265034
9. B2 isoform of ecdysone receptor is critical for the development of Malpighian tubules and is expressed from early stages of its development. PMID: 25476260
10. identify a previously uncharacterized enzyme of ecdysone biosynthesis, GstE14, and find that ecdysone triggers pri expression to define the onset of epidermal trichome development PMID: 25344753
11. EcR signaling modulates the effects of EGFR signaling by promoting an undifferentiated state in early stage testicular cyst cells. PMID: 25169192
12. Non-conserved residues within the alpha-helix 2, forming the EcRDBD hydrophobic core, represent a specific structural element that contributes to instability. PMID: 24465866
13. EcR genetically interacts with the NURF chromatin-remodeling complex, which maintains cyst stem cells. ecdysone signaling acts through distinct cell types and effectors to ensure both ovarian and testis stem cell maintenance. PMID: 25093968
14. dTDP-43 directly and dramatically increased the expression of the neuronal microtubule-associated protein Map205, resulting in cytoplasmic accumulations of the ecdysteroid receptor. PMID: 23333275
15. The degradation of EcR isoforms was investigated and evidence that N-terminal degradation is modulated by isoform-specific ubiquitination, is provided. PMID: 22568680
16. These findings suggest that EcR-mediated ecdysone signal is significant in lipid metabolism in insects. PMID: 22503687
17. Hormonal activation of let-7-C microRNAs via EcR is required for adult Drosophila melanogaster morphology and function. PMID: 22510985
18. Receptor protein concentration is an important factor that influences ecdysteroid receptor activity. PMID: 21895819
19. Pzg is associated with EcR in vivo and required for the transcriptional induction of EcR target genes, whereas reduced ecdysteroid levels imply a NURF-independent function of Pzg. PMID: 21385730
20. EcR-A is required in fru P1-expressing neurons for wild-type male courtship behaviors and the establishment of male-specific neuronal architecture. PMID: 19646872
21. Spatial patterns of ecdysteroid receptor activation during the onset of Drosophila metamorphosis. PMID: 11923209
22. every isoform supports development in many tissues but only EcR-A can support developemnt in the margins of the wing discs and only EcR-B2 can do so in the larval epidermis and border cells of the developing egg chamber PMID: 12466195
23. flies that are heterozygous for mutations of the ecdysone receptor exhibit increases in life-span and resistance to various stresses, with no apparent deficit in fertility or activity PMID: 12610309
24. different effects of the same point mutations on ligand binding to ecdysone receptor indicate that the ligand-binding pocket is modified by heterodimerization PMID: 12674504
25. Mutation of EcR abolishes the induction of genes encoding factors from the hedgehog, Notch, EGF, dpp, and wingless pathways. PMID: 12852852
26. We tested for the ability of the different isoforms to rescue the lack of dendritic pruning that is characteristic of mutants lacking both EcR-B1 and EcR-B2 PMID: 12963111
27. QSAR and CoMFA models for binding of a training set of 66 ecdysteroids and 97 diacylhydrazines to the D. melanogaster ecdysone receptor demonstrate the relative binding orientation of the two ligand families. PMID: 13677482
28. This study revealed that the ecdysone receptor (EcR/USP) Ultraspiracle heterodimer displays isoform-specific capabilities. PMID: 17201771
29. Deficiency of the ecdysone receptor system may have a role in courtship initiation by adult male fruit flies. PMID: 17238001
30. tissue-specific modulation of EcR activity by the Ras signaling pathway refines temporal ecdysone signals that regulate ovarian follicle cell differentiation PMID: 17436275
31. Indicate that the architecture of the E-domain of EcR is important for nuclear localization even in the absence of a ligand. PMID: 17884338
32. These findings suggest that DART1, a histone arginine methyltransferase, is a co-repressor of EcR that is indispensable for normal pupal development in the intact fly. PMID: 18468516
33. Coordinated expression of the glue genes midway through the third instar is mediated by 20-hydroxyecdysone (20E) acting to induce genes of the Broad Complex (BRC) through a receptor that is not an EcR/USP heterodimer. PMID: 18566664
34. Down-regulation of Notch signaling and activation of ecdysone receptor (EcR) are required for the endocycle/gene amplification switch in these cells. PMID: 18779369
35. The EcR-B1 isoform is required during early oogenesis for follicle cell survival and disruption of its function causes apoptotic cell death induced by caspase. PMID: 19015542
36. Ligand binding to ecdysone receptor heterodimers with Usp PMID: 19428996
37. steroid hormone receptor EcR finely modulates Drosophila lifespan during adulthood in a sex-specific PMID: 19486910
38. knocking down EcR derepresses genes that are normally repressed by unliganded EcR, thereby allowing wing patterning to progress PMID: 19515698

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KEGG: dme:Dmel_CG1765

STRING: 7227.FBpp0291631

UniGene: Dm.4159