Recombinant Drosophila melanogaster Forkhead box protein O (foxo), partial

1. dFOXO and FER2 act in parallel to protect protocerebral anterior medial neurons from different forms of cellular stress. PMID: 29529025
2. FoxO activation is responsible for restricting overgrowth of Tsc1 mutant tissue. The overgrowth correlates with high TORC1 activity, and activating TORC1 downstream of Tsc1 by overexpression of Rheb is sufficient to enhance tissue growth. PMID: 29677182
3. This study implicates FOXO factors, the evolutionarily conserved determinants of animal longevity, in the mechanisms of nutritional programming of animal lifespan. PMID: 28076775
4. this study shows that intestinal FoxO signaling is required to survive oral infection in Drosophila PMID: 26627459
5. This study highlights D. melanogaster as a model of cardiac aging and FOXO as a tightly regulated mediator of proteostasis and heart performance over time. PMID: 28090761
6. FoxO regulates dendrite structure and function and FoxO-mediated pathways control microtubule dynamics and polarity. PMID: 27546375
7. identify the regions of the Hsp70 promoter essential for FOXO-dependent transcription using in vitro methods and find a physiological role for FOXO-dependent expression of heat shock proteins in vivo. PMID: 27435672
8. subtle manipulation of foxo through Akt1 can enhance survival during adverse nutrient conditions in Drosophila. PMID: 26783834
9. Pll physically interacts with dFoxO and phosphorylates dFoxO directly. This study not only identifies a previously unknown physiological function of pll in cell death, but also shed light on the mechanism of IRAKs in tumorigenesis. PMID: 26474173
10. Fasting increases survival to cold in FOXO mutant Drosophila melanogaster. PMID: 25663303
11. reveals an unanticipated connection among dFOXO, stress responses, and the efficacy of small RNA-mediated gene silencing PMID: 26553999
12. APLP1 is able to induce cell death, and FoxO is a crucial downstream mediator of APLP1's activity. PMID: 25740230
13. the presence of feedback in the regulation of dFOXO gene expression by juvenile hormone was established for the first time. PMID: 26606805
14. Neuroendcrine FOXO extends lifespan independently of foxo in other cell types. Gut/adipose FOXO requires foxo in other tissues to alter metabolism. PMID: 24508462
15. APP modulates FoxO-mediated cell death through AICD, which acts as a transcriptional co-activator of FoxO. PMID: 24832605
16. Starvation induces FoxO-dependent mitotic-to-endocycle switch pausing during Drosophila oogenesis PMID: 24993942
17. We find that taste inputs shorten lifespan through inhibition of the insulin pathway effector dFOXO, whereas other taste inputs lengthen lifespan in parallel to this pathway. PMID: 24847072
18. Dawdle, an Activin ligand, is bound and repressed by dFOXO when reduced insulin/IGF extends lifespan. PMID: 24244197
19. we found that dFOXO was required for the increase in DLP expression in DJ-1beta mutants and that dFOXO activity was increased in the heads of DJ-1beta mutants. PMID: 23593018
20. the NO-FoxO axis contributes to DA neurodegeneration in LRRK2-linked PD PMID: 22393355
21. FoxO degradation is a component of a stabilizing, protective response to cytoskeletal insult. PMID: 22312004
22. FOXO is recognized as a key player in the response of size, immunity, and longevity to changes in developmental nutrition, stress, and oxygen levels. PMID: 22102829
23. The insulin/insulin-like growth factor-like signaling (IIS)-mediated longevity requires dFOXO activity. PMID: 21443682
24. foxo indeed contributes to how chico increases Drosophila lifespan PMID: 21518241
25. dFOXO is required for only a part of the transcriptional response to reduced insulin-like growth factor signalling. PMID: 21694719
26. FOXO plays key role in organism stress response after low dose irradioation. PMID: 20734804
27. IRES mediated translation of dFoxO and dInR may be essential to ensure function and sensitivity of the insulin signaling pathway during fasting. PMID: 20634900
28. data demonstrate that wild-type p53 over-expression can regulate life span independent of foxo, and suggest that foxo acts in males to produce sexually antagonistic life span effects of p53 PMID: 19840842
29. antimicrobial peptide induction is lost in foxo null mutants but enhanced when FOXO is overexpressed PMID: 20090753
30. Expression of dFOXO during early larval development causes inhibition of larval growth and alterations in feeding behavior; inhibition of larval growth is reversible upon discontinuation of dFOXO expression. PMID: 12844367
31. Dfoxo controls cell count by downstream and feedback regulation of the insulin receptor pathway. PMID: 12893776
32. regulates ageing when activated in the adult pericerebral fat body; this limited activation reduces expression of Drosophila insulin-like peptide dilp-2 synthesized in neurons, and represses endogenous insulin-dependent signalling in peripheral fat body PMID: 15175753
33. induced expression of dFOXO in the fat body from the onset of adulthood increased life-span and reduced fecundity of female flies but had no effect on male life-span PMID: 15192154
34. Foxo restricts IIS activity systemically by repressing IIS ligand expression in neuroendocrine cells. PMID: 15820683
35. This study shows that reduction of dTOR activity blocks the insulin resistance and metabolic syndrome phenotypes associated with increased activity of the insulin responsive transcription factor, dFOXO. PMID: 16890541
36. Akt and FOXO dysregulation contribute to Mycobacterium marinum infection-induced wasting in Drosophila. PMID: 17055976
37. FOXO is a major coordinator of the transcriptional response to nutrients downstream of insulin suggesting that mitochondrial biogenesis is linked to insulin signaling via FOXO-mediated repression of a PGC-1 homolog. PMID: 17090700
38. UV-induced apoptosis is repressed by receptor tyrosine kinase-mediated inactivation of Foxo. PMID: 17183370
39. These findings indicate that alteration of expression levels of dFOXO may have declining effects on IIS (insulin/insulin growth factor-like signaling)status with age PMID: 17465980
40. foxo mutants show a rapid decline in rest:activity rhythms with age, supporting the idea that the increase of oxidative stress contributes to age-associated degeneration of behavioral rhythms. PMID: 17895391
41. Results show that a direct target of FOXO was myc and the effects of FOXO on growth and metabolism was mediated by Myc. PMID: 18177722
42. Study shows that in flies, dFOXO regulates lipase 4, a Drosophila homologue of human acid lipases; dFOXO binds and activates the dLip4 promoter, in vitro and in vivo, and regulates dLip4 expression. PMID: 18234213
43. Drosophila FOXO null did not have an extended lifespan. Overexpression of in the adult fat body dFOXO modulated the response to DR PMID: 18241326
44. Tuberous sclerosis complex 1 mutations cause increased FOXO levels, resulting in elevated expression of FOXO-regulated genes, some of which are known to antagonize growth-promoting pathways. PMID: 18299344
45. Activation of JNK/FOXO signaling in neurons increased the Jafrac1 expression level under both normal and oxidative stressed conditions. PMID: 19720829

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KEGG: dme:Dmel_CG3143

STRING: 7227.FBpp0293589

UniGene: Dm.3957