Recombinant Drosophila melanogaster Homeobox protein vnd (vnd), partial

1. NKX2-5 and MLC2v double-positive cells possess ventricular-like properties. The results demonstrate that the NKX2-5(eGFP/w) and MLC2v(mCherry/w) hPSCs provide a powerful model system to capture region-specific cardiac differentiation from early to late stages. Our study would facilitate subtype-specific cardiac development and functional analysis using the hPSC-derived sources. PMID: 29175323
2. the Neurogenic Ectoderm Enhancer (NEE) at vnd takes additional input from the complementary Dpp, dorsal, twist gradient via a conserved Schnurri/Mad/Medea silencer element (SSE) unlike NEEs at brk, sog, rho, and vn PMID: 23499655
3. The results obtained from this study indicate that expression of at least four genes, uzip, CG7687, SytIV, and ase, are regulated by Vnd. PMID: 19863267
4. Tthe vnd/NK-2 gene encodes an additional protein isoform (NK-2B) that differs from the known one (NK-2A) in its N-terminal domain. PMID: 21422076
5. excludes Meltrin expression from the embryonic ventral neuroectoderm PMID: 20705134
6. Vnd segment-specifically affects ind expression; it represses ind in the tritocerebrum but positively regulates ind in the deutocerebrum by suppressing Msh PMID: 20673828
7. DNA-binding analysis using embryonic nuclear protein also demonstrates that Vnd interacts with other nuclear proteins, suggesting the existence of Vnd as a complex PMID: 20587330
8. NK2 and Antp with uncharged N-tails show behavior very similar to that of truncated Antp and NK2, indicating that the disordered tails affect the unfolded state by non-native charge-charge interactions. PMID: 19919153
9. nucleotide sequences regulate the expression of the vnd/NK-2 gene; vnd/NK-2 gene can be activated in different ways in different neuroblasts; pattern of vnd/NK-2 gene expression in neuroblasts of the ventral nerve cord is the sum of partial patterns. PMID: 11752402
10. expression is required for both neural and glial specification PMID: 11793359
11. In vnd mutants, head neuroectoderm Nk6 expression is abolished where it is normally co-expressed with vnd. PMID: 12128210
12. AAGT sequence determines binding kinetics for vnd homeodomain PMID: 12232052
13. molecular basis for the phenotypic alterations observed on ectopic expression of the Y54M vndNK-2 gene during embryogenesis PMID: 12626758
14. structural alteration of the DNA-bound A35T mutant vnd/NK-2 protein may constitute the basis of the observed early embryonic lethality PMID: 14580198
15. Results indicate that vnd is required for the genesis and proper identity specification of tritocerebral neural lineages during embryonic brain development of Drosophila. PMID: 17038518
16. the Nk-2 box contributes to the repression activity of Vnd by stabilizing its interaction with the co-repressor, Groucho PMID: 17070676
17. Data show that expression of gene vnd is invloved in dorsoventral regionalization within the developing brain and truncal nervous system in Drosophilia. PMID: 18683637

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KEGG: dme:Dmel_CG6172

STRING: 7227.FBpp0070105