Recombinant Drosophila melanogaster Homeotic protein ultrabithorax (Ubx)

1. Ubx and AbdA collaborate with the transcription pausing factor M1BP to regulate gene transcription. PMID: 28871058
2. Ubx orchestrates the interaction between two cell types, muscles and motoneurons, to regulate establishment of the ventrolateral neuromuscular network. PMID: 27913640
3. VEGF-Ubx fibers attract outgrowing sprouts in an aortic ring assay and induce vessel formation in a chicken embryo chorioallantoic membrane (CAM) assay. Collectively, these results demonstrate that the activity of VEGF remains intact in Ubx materials. PMID: 27715013
4. Results show that Ubx targets developmental regulators via strongly clustered binding sites and allow us to hypothesize that regulation by Ubx might involve Polycomb group proteins to maintain specific regulatory states in cooperative or mutually exclusive fashion. PMID: 27575958
5. Ubx is required to repress Dad for the regeneration of acid-producing copper cells PMID: 27570230
6. Ubx fibers are cytocompatible with cultured primary human vascular cells. PMID: 23596050
7. Interactions formed by the Drosophila melanogaster Hox transcription factor Ultrabithorax (Ubx), which contains both structured and disordered regions, were evaluated. PMID: 25286318
8. analysis of the CTCF binding site in the ultrabithorax gene in the Drosophila bithorax complex PMID: 25368383
9. Genome-level identification of targets of Hox protein Ultrabithorax in Drosophila PMID: 22355720
10. replication timing analysis differing for BX-C gene expression states, PcG distribution, and chromatin domain conformation revealed a cell-type-specific replication program that mirrors lineage-specific BX-C higher-order structures. PMID: 23437006
11. This study demonstrated that Ubx plays a critical role in conferring segment-appropriate morphology and survival on individual neurons in the adult-specific ventral central nervous system.. PMID: 22967828
12. Data show that the bithorax complex is an approximately 330kb genomic region that is responsible for directing the transcription of three homeotic (Hox) genes Ultrabithorax (Ubx), abdominal-A (abd-A) and Abdominal-B (Abd-B) during embryonic development. PMID: 21821017
13. Ultrabithorax regulates distinct sets of target genes at successive stages of Drosophila haltere morphogenesis. PMID: 21282633
14. Results suggest that the expression of cas is segment-specifically regulated negatively by Ubx and abdA genes, but positively by the AbdB gene. PMID: 20563987
15. Data suggest that alternative splicing of Ultrabithorax might primarily affect the regulatory capacity of the isoforms rather than their DNA-binding patterns. PMID: 21115609
16. During embryonic development Ubx produces mRNAs with variable 3'UTRs in different regions of the embryo. Each species has different sets of miRNA target sites, converting each class of Ubx mRNA into a considerably different substrate for miRNA regulation. PMID: 20667912
17. the structural changes produced by alternative splicing have functional implications for Ubx protein function in vivo and in vitro. PMID: 20038634
18. The homeotic genes Ultrabithorax and abdominal-A regulate late differences in neutroblast proliferation in the thorax and abdomen. Misexpression of either gene in thoracic neuroblasts after segregation is sufficient to induce abdominal behaviour. PMID: 9651493
19. identification of a highly conserved transcriptional repression domain in the carboxy-terminal region of the Drosophila Ultrabithorax (Ubx) protein PMID: 11859369
20. Naturally selected alteration of the Ubx protein is linked to the evolutionary transition to hexapod limb pattern. PMID: 11859370
21. In females only, most mutations result in decrease in dienes and an equal increase in monoenes in cuticular hydrocarbons. PMID: 11865713
22. Ultrabithorax (Ubx) controls specific differences between the bristle patterns of the second and third thoracic segments (T2 and T3) of Drosophila melanogaster PMID: 12000797
23. Ubx directly regulates a flight appendage-specific cis-regulatory element of the spalt (sal) gene, multiple monomer Ubx-binding sites are required to repress this cis-element and individual Ubx-binding sites are sufficient to mediate partial repression. PMID: 12070087
24. Heart tube patterning in Drosophila requires integration of axial and segmental information provided by the Bithorax Complex genes and hedgehog signaling. PMID: 12223408
25. Ultrabithorax (Ubx) suppresses limb formation in the abdomen by repressing the leg selector gene Distalless PMID: 12408801
26. Interchange of DNA-binding modes in the deformed and ultrabithorax homeodomains: a structural role for the N-terminal arm PMID: 12419257
27. we provide genetic evidence that, in abdominal segments, Ubx and Abd-A, two homeotic proteins not previously thought to participate in the segmentation cascade, are also involved in the repression of target genes by En. PMID: 12506003
28. Segments of the leg regulate their size in response to Ubx expression through qualitatively different mechanisms. PMID: 12679108
29. Data report the mapping of binding sites for ultrabithorax, Abd-A and Abd-B on polytene chromosomes in the Drospohila fat body. PMID: 12835385
30. Hox transcription factor ultrabithorax Ib physically and genetically interacts with disconnected interacting protein 1, a double-stranded RNA-binding protein PMID: 15039447
31. Data show that a polycomb response element from Drosophila ultrabithorax potently silences different heterologous enhancers and promoters that are normally not subject to polycomb repression. PMID: 15056613
32. can repress knot expression at either of two sequences PMID: 15753212
33. Down-regulation of Egfr/Ras pathway is critical for haltere fate specification: over-expression of positive components of this pathway causes significant haltere-to-wing transformations. PMID: 16815386
34. The ultrabithorax Hox gene of Drosophila controls haltere size by regulating the Dpp pathway. PMID: 17050628
35. identified target genes of the Hox protein Ultrabithorax (UBX)), which modifies the genetic regulatory network of the wing to generate the haltere, a modified hindwing PMID: 17174297
36. FSH-S acts as a critical component of a regulatory circuitry mediating long-range effects of distant enhancers. PMID: 17526731
37. the evolved difference in Ubx function reflects evolution of a leg-specific enhancer PMID: 17640629
38. intrinsically disordered regions regulate Hox (ultrabithorax)-DNA binding PMID: 18508761
39. if Ubx expression levels are inappropriately elevated, overriding the auto-regulatory control, a permanent repression of Ubx is established PMID: 18715947
40. The presence of the YPWM motif in UbxIa inhibits DNA binding only to Ubx-Extradenticle heterodimer binding sites, potentially functioning in vivo to prevent Ubx monomers from binding and misregulating heterodimer target genes. PMID: 19481089
41. Increases in Ubx levels are capable of silencing all enhancer input into Ubx transcription, resulting in complete silencing of this gene. PMID: 19730678

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KEGG: dme:Dmel_CG10388

STRING: 7227.FBpp0082793

UniGene: Dm.21668