Recombinant Drosophila melanogaster Lethal (2) giant larvae protein, partial

1. Here we show that PTEN mutation impacts aPKC and Lgl protein levels also in Drosophila. Moreover, we demonstrate that PI3K activation is not sufficient to trigger tumourigenesis, while aPKC promotes hyperplastic growth of the neuroepithelium and a noticeable expansion of the type II neuroblasts. PMID: 29445734
2. Novel Genes Interacting with Lgl, aPKC, and Crb Cell Polarity Genes in Epithelial Tissues, is reported. PMID: 28611255
3. results strongly suggest that the phenotypes we found in Sco mutants are more closely associated with the lgl allele than ectopic Snail activity PMID: 29261681
4. Lgl plasma membrane (PB) domain contains all the identified phosphorylation sites of aPKC and Aurora kinases, providing a molecular mechanism by which phosphorylations neutralize the positive charges on the PB domain to inhibit Lgl PM targeting. PMID: 26483556
5. AurA and aPKC exert the spatiotemporal control of Lgl distribution to achieve unique cell polarity roles in distinct cell types. PMID: 25484294
6. Aurora A and B kinases directly phosphorylate Lgl to promote its mitotic relocalization. PMID: 25484300
7. Lgl is a critical downstream target of the Par6-aPKC cell polarity complex. Lgl1 forms two distinct complexes in vivo, Lgl1-NMIIA and Lgl1-Par6-aPKCzeta in different cellular compartments. PMID: 25482644
8. Rate of phosphorylation between sites differs at multiple sites in the atypical lethal giant larvae protein, regulating localization behaviors at the cortex. PMID: 25000553
9. scrib and lgl expression in the somatic lineage of the Drosophila testis, similar to what was previously shown for dlg, was indispensable for testis development and homeostasis, as depletion of these genes resulted in extensive testes defects. PMID: 23585349
10. presynaptic LGL scaffold facilitates the assembly of active zone fusion sites to regulate synaptic vesicle cycling, and that the postsynaptic LGL scaffold modulates glutamate receptor composition and function. PMID: 23444371
11. Data indicate that loss of Lethal giant larvae (Lgl) tumor suppressor in the wing primordium induced epithelial neoplasia in its Homothorax (Hth)-expressing proximal domain. PMID: 23708122
12. HSF1 and LGL interact during ontogenesis and stress-defending processes PMID: 22567869
13. The p127 (l(2)gl)process nuclear proteins and then released from p127 (l(2)gl) by nmMHC to allow their binding to chromatin. PMID: 21989237
14. The result reveals role for Lgl in neuronal specification and maintenance and show that the Hippo pathway is reimplemented for sensory neuron fate by combining canonical and noncanonical regulatory steps. PMID: 22055343
15. These data indicate that Mahjong interacts with Lgl biochemically and genetically and that Mahjong and Lgl function in the same pathway to regulate cellular competitiveness. PMID: 20644714
16. Data show that lgl mutant cells may form tumors if they acquire constitutive activity of the Ras pathway (lgl(-) UAS-ras(V12)), which confers proliferation advantage through inhibition of the Hippo pathway. PMID: 20679206
17. Lgl depletion or aPKC overexpression results in comislocalization of Hippo and Ras-associated domain family protein (RASSF), consistent with RASSF's ability to block Hippo activation by Salvador. PMID: 20362447
18. JNK signaling links lgl mutations to disruption of the cell polarity and epithelial organization in Drosophila imaginal discs. PMID: 20066009
19. hitherto unreported role for Lgl as a regulator of Sanpodo during asymmetric cell division in the adult peripheral nervous system PMID: 15901829
20. Lgl regulates cell fate by controlling Partner-of-Numb cortical localization, asymmetric localization of Numb and Neuralized, and plasma-membrane localization of Sandopo. PMID: 15916953
21. Clonal analysis in larval brains showed that pins mutant neuroblasts rapidly fail to self-renew, whereas lethal giant larvae (lgl) mutant neuroblasts generate multiple neuroblasts PMID: 16357871
22. The loss of one dose of tumor suppressor lgl+ provided for increased survival rate and life span of lgl/+ heterozygotes under stress conditions. PMID: 17352292
23. aPKCzeta cortical loading is associated with Lgl cytoplasmic release and tumor growth in Drosophila and human epithelia PMID: 17369850
24. lgl- clones in the larval eye disc exhibit ectopic expression of the G1-S regulator, Cyclin E, and ectopic proliferation, but do not lose apico-basal cell polarity. PMID: 17870065
25. Lgl and its phosphorylation by aPKC may form a conserved regulatory circuitry in polarization of various cell types. PMID: 18094021
26. lgl is implicated in the formation of the initial AP asymmetry and the patterning of the AP and DV axes in the oocyte by acting in the specification of a subset of somatic follicle cells. PMID: 18268543
27. Results show that embryonic exposure to heat stress and dosage of Lgl provide an adaptive advantage in later life in Drosophila. PMID: 18536270
28. effect of impulse heating at the preembryonal stage was bidirectional: positive in the case of impulse warming of mature eggs and negative during egg differentiation. Deletion of one allele of the tumor suppressor gene in lgl/+ females increased survival PMID: 19239111

Show More

Hide All

KEGG: dme:Dmel_CG2671

STRING: 7227.FBpp0297544

UniGene: Dm.2784