Recombinant Drosophila melanogaster Metabotropic glutamate receptor (mGluRA), partial

Code CSB-YP309352DLU
MSDS
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Source Yeast
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Code CSB-EP309352DLU
MSDS
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Source E.coli
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Code CSB-EP309352DLU-B
MSDS
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP309352DLU
MSDS
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Source Baculovirus
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Code CSB-MP309352DLU
MSDS
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Source Mammalian cell
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Product Details

Purity
>85% (SDS-PAGE)
Target Names
mGluR
Uniprot No.
Alternative Names
mGluR; Glu-RA; GluRA; mGluRA; CG11144Metabotropic glutamate receptor; DmGluRA
Species
Drosophila melanogaster (Fruit fly)
Protein Length
Partial
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose.
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

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Target Background

Function
G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors.
Gene References into Functions
  1. transgenic flies expressing a number of GPCRs in the photoreceptor cells PMID: 11964379
  2. sterol-rich lipid rafts act as positive allosteric regulators of DmGluRA. PMID: 12923296
  3. Two roles were found for DmGluRA in presynaptic mechanisms: (1) modulation of presynaptic excitability properties important for control of activity-dependent neurotransmitter release and (2) modulation of synaptic architecture. PMID: 15483129
  4. Metabotropic glutamate receptor A (mGluRA) and fragile X mental retardation (Fmr) protein genetically interact in behavioral movement regulation. PMID: 18280750
  5. we report DmGluRA expression in most neuropile areas in both larvae and adults, but not in the lobes of the mushroom bodies PMID: 18303583
  6. DmGluRA mutations increase neuronal excitability by preventing PI3 kinase (PI3K) activation and consequently hyperactivating the transcription factor Foxo PMID: 19043547

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Subcellular Location
Cell membrane; Multi-pass membrane protein.
Protein Families
G-protein coupled receptor 3 family
Tissue Specificity
Expressed in the neurons of the larval CNS from the beginning of the first until the third instar. Expression in the third-instar larval CNS is restricted to a discrete number of somas and projections in the brain lobes and in the ventral ganglion. In the
Database Links

KEGG: dme:Dmel_CG11144

STRING: 7227.FBpp0305080

UniGene: Dm.1789

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