Recombinant Drosophila melanogaster Protein PDF (Pdf)

1. PDF feedback is required for maintaining normal oscillation pattern in CLK-driven transcription. PMID: 27732848
2. PDF has dual functions in clock resetting and pacemaker output. PMID: 24643294
3. The PDF-mediated increase in cAMP might lengthen circadian period by directly enhancing PER stability PMID: 24707054
4. a neuroendocrine pathway, defined by PDF, couples the CNS to the physiological output of peripheral clock cells that produce pheromones. disruption of pathway reduces male sex pheromones and results in sex-specific differences in mating behavior. PMID: 23849197
5. Tip60 regulates PDF expression in the small ventrolateral neurons. PMID: 22982579
6. age-associated reduction of PDF may cause attenuation of intercellular communication in the circadian neuronal network and of TIM cycling, which may result in the age-related rhythm decay PMID: 23223368
7. Autoreceptor control of peptide/neurotransmitter corelease from PDF neurons determines allocation of circadian activity in drosophila. PMID: 22938867
8. findings support a hypothesis that PDF signaling components within target cells are sequestered into "circadian signalosomes," whose compositions differ between E and M pacemaker cell types. PMID: 22679392
9. Intestinal PDF acts at a distance on the renal system, where it regulates ureter contractions. PMID: 22778427
10. activation of PDF pathway alone by constant light conditions leads to the complex locomotor rhythm through desynchronized oscillation among some of the clock neurons PMID: 21708159
11. Circadian pacemaker neurons expressing the neuropeptide PDF are especially important for morning anticipation and free-running rhythms. PMID: 20362452
12. These results reveal the neuroanatomical basis of PDF's various circadian functions. PMID: 20011537
13. Blocking Shibire function via overexpression of a dominant negative mutant of Shibire in PDF neurons slowed down the behavioral rhythm. This effect was absent in PDF receptor null mutants, indicating interference with PDF receptor-mediated endocytosis. PMID: 19916833
14. The lateral neurons evening oscillator integrates light inputs and PDF signaling to control Drosophila diurnal behavior, revealing a new clock-independent function for PDF. PMID: 19820704
15. Pdf is not required to maintain circadian protein oscillations under constant conditions; however, it is required to coordinate the phase and amplitude of such rhythms among the diverse pacemakers. PMID: 15356209
16. circadian rhythm in olfactory response persisted in the absence of the pigment-dispersing factor neuropeptide PMID: 15851530
17. robust PDF cycling in sLNv termini plays no more than a minor role in the Drosophila circadian system and is apparently not even necessary for clock output function PMID: 16603675
18. PDF signaling is not required for robust activity rhythms in constant light as opposed to its requirement in constant darkness. PMID: 18044989
19. Cleavage by a member of the Drosophila neprilysin family of endopeptidases is the most likely mechanism for inactivating synaptic PDF and that neprilysin might have an important role in regulating PDF signals within circadian neural circuits. PMID: 18055635
20. Data suggest that functionally relevant signals from pacemaker to non-pacemaker clock neurons and other downstream targets rely both on PDF signaling and pacemaker electrical activity. PMID: 18375861
21. PDF has different effects on Drosophila's circadian clocks in the accessory medulla and in the dorsal brain PMID: 18838607
22. significant difference in the regulatory mechanisms of Pdf transcription between Drosophila melanogaster and D. virilis PMID: 19153257

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KEGG: dme:Dmel_CG6496

STRING: 7227.FBpp0084396

UniGene: Dm.21687