Recombinant Drosophila melanogaster Protein groucho (gro), partial

1. Groucho-mediated repression revealed by genome-wide analysis of Groucho binding and activity PMID: 28245789
2. Gro central domains mediate multiple interactions required for repression, thus functioning as a regulatory hub PMID: 26483546
3. Our results demonstrate that Gro is recruited to local sites by transcription factors to attenuate rather than silence gene expression by promoting histone deacetylation and polymerase pausing PMID: 25165826
4. Genes activated by Notch signaling at the dorsal-ventral boundary of wing disc fall into classes affected differently by the loss of kinase module subunits. The distinctions do not result from different requirements for mastermind. PMID: 21793099
5. Gro-mediated histone deacetylation results in increased nucleosome density leading to transcriptional repression. PMID: 20405012
6. Reduction of gro function enhances H mutant phenotypes and suppresses N phenotypes in the adult mechanosensory bristle. This activity of gro is surprising, because it is directed oppositely to its traditionally defined role as a neurogenic gene. PMID: 12154126
7. Comparison of gro and Atro/sbb mutant phenotypes suggests that they do not function together, but instead that they may interact with the same transcription factors. PMID: 16624911
8. Here, we identify several missense mutations in Drosophila Gro, which demonstrate peptide binding to the central pore of the WD (WD40) beta propeller domain in vitro and in vivo PMID: 16762837
9. These results show that homo-oligomerization of Gro is not obligatory for its action in vivo, and that Gro represses transcription through more than one molecular mechanism. PMID: 18034187
10. Phosphorylation of Groucho provides a widespread, long-term mechanism by which receptor tyrosine kinase signals control target gene expression in embryogenesis. PMID: 18216172
11. These findings indicate that Groucho sumoylation increases its corepressor activity by enhancing the recruitment of HDAC1 to Groucho corepressor complex. PMID: 19101520

Show More

Hide All

KEGG: dme:Dmel_CG8384

STRING: 7227.FBpp0089115

UniGene: Dm.1340