Recombinant Drosophila melanogaster Protein yorkie (yki)

1. Yorkie functions in a feedforward "amplifier" loop that promotes myosin activation PMID: 30032991
2. Wts mediates effects of insulin and the neuropeptide prothoracicotropic hormone on regulation of ecdysone production through Yorkie and the microRNA bantam. Thus coupling insulin signaling with ecdysone production to adjust systemic growth in response to nutritional conditions during development. PMID: 28528906
3. miR-8 modulates a positive growth regulator, Yorkie, and a negative growth regulator, brinker Deregulation of this network can result in the loss of tissue homeostasis and the formation of tumors. PMID: 29945869
4. BAP complex depletion causes upregulation of the Wingless (Wg) and Decapentaplegic (Dpp) morphogens to promote tumor formation in cooperation with Yki. PMID: 28754838
5. These results support a model in which elevated Yki signaling increases the number of hemocytes, which become melanotic tumors as a result of elevated JAK/STAT signaling. PMID: 28620086
6. This study presents successfully overexpressed full length recombinant Tgi and Yki, experimentally confirms that intrinsic structural disorder is common to both proteins, and assesses binding of the Yki WW domains to the three Tgi PPxY motifs using nuclear magnetic resonance and isothermal titration calorimetry. PMID: 29257682
7. miR-285 directly targets the Yki cofactor Mask to suppress Yki activity and down-regulates the expression of its downstream target cyclin E, a key regulator of cell cycle. PMID: 28265104
8. In ovary escort cells (ECs) both Hh and Yki limit production of BMP ligands to allow germline differentiation. Loss of Yki produced a more severe germarial phenotype than loss of Hh signaling and principally induced a different BMP ligand. Moreover, Yki activity reporters and epistasis tests showed that Yki does not mediate the key actions of Hh signaling in ECs. PMID: 28619819
9. We demonstrate the efficacy of the MARGE technique by flip-out (clonal and disc-wide) of a Ubi-GFP-carrying construct in imaginal discs, and by inducing a known yki mutant phenotype in the Drosophila ovary PMID: 27696669
10. This study identified a potential nuclear localization signal at the N-terminal end of Yorkie as well as a critical role for Importin alpha 1 in Yorkie nuclear import. PMID: 26887950
11. Data suggest that Tor (target of rapamycin protein) signaling governs Yki action after reaching nucleus by allowing access to target genes via Hpo (Hippo protein) pathway; Tor also promotes wing growth by liberating Yki from nuclear seclusion. PMID: 26474042
12. Yki directly associates with NcoA6. PMID: 25017066
13. Yki activity was cell-autonomously decreased but non-cell-autonomously elevated in tissues where the adherens junctions components E-cadherin or alpha-catenin were knocked down during imaginal disc development. PMID: 25624491
14. epithelial tube size regulation defines new non-apoptotic roles for Yki, DIAP1 and Ice PMID: 25036253
15. the Misshapen-Warts-Yorkie pathway acts in enteroblasts to control niche signaling to intestinal stem cells PMID: 25453828
16. Drosophila casein kinase 2 (CK2) promotes warts protein to suppress Yorkie protein activity for growth control. PMID: 25320084
17. Yorkie Controls Cell Fusion and Polyploidization in wound healing. PMID: 24184101
18. This study identifies a novel protein Sd-Binding-Protein (SdBP)/Tgi, which directly competes with Yki for binding to Sd through its TDU domains and inhibits the Sd-Yki transcriptional activity. PMID: 23999857
19. The association of Yki with GAF and BRM establishes a direct connection between Yki and chromatin-remodeling complexes as a mechanism by which Yki promotes transcription. PMID: 23395637
20. Mask is a novel cofactor for Yki/YAP required for optimal Yki/YAP activity during development and oncogenesis. PMID: 23333314
21. Mask forms a complex with Yki and its binding partner, Scalloped (Sd), on target-gene promoters and is essential for Yki to drive transcription of target genes and tissue growth. PMID: 23333315
22. Yki activity is elevated among wild type cells. PMID: 22705500
23. Data show that the non-cell autonomous induction of DIAP-1 is mediated by Yorkie, the conserved downstream effector of Hippo signaling. PMID: 22679484
24. crosstalk between the insulin/IGF signaling pathway and Yorkie leads to coordinated regulation of these two pathways PMID: 22609549
25. Yorkie promotes expression of the microRNA gene bantam in glia, and bantam promotes expression of Myc, which is required for Yorkie and bantam-induced glial proliferation. PMID: 22069188
26. The data establish Myopic as a Yorkie regulator and implicate Myopic-dependent association of Yorkie with endosomal compartments as a regulatory step in nuclear outputs of the SWH pathway. PMID: 21571226
27. show that the Hippo pathway components Warts and Yorkie mediate a transition from low- to high-level ISC proliferation to facilitate regeneration. The Hippo pathway regulates growth in diverse organisms and has been linked to cancer PMID: 20727758
28. Activation of Yki in intestinal stem cells is sufficient to increase ISC proliferation, a process involving Yki target genes that promote division, survival and the Upd cytokines. PMID: 21098564
29. Here we identify Yorkie (Yki), the Drosophila ortholog of the mammalian transcriptional coactivator yes-associated protein (YAP), as a missing link between Wts and transcriptional regulation. PMID: 16096061
30. Warts inhibits Yki nuclear localization in vivo, and can promote binding of Yki to 14-3-3 proteins in cultured cells. PMID: 18256197
31. Results show that although Ser168 is the most critical site, all three phosphorylation sites influence Yki localization and activity in vivo, and can be sites of regulation by Wts. PMID: 19330023
32. Hth and Yki are bound to a DNA sequence approximately 14 kb upstream of the bantam hairpin in eye imaginal disc cells PMID: 19762509
33. Genetic interaction between the Drosophila YAP orthologue Yorkie and Egfr signalling components supports the link between these two highly conserved signalling pathways. PMID: 19935651

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KEGG: dme:Dmel_CG4005

STRING: 7227.FBpp0288697

UniGene: Dm.4183