Product Details

Purity

>85% (SDS-PAGE)

Target Names

Stat92E

Uniprot No.

Q24151

Alternative Names

Stat92E; MARE; mrL; Stat; CG4257; Signal transducer and transcription activator; d-STAT; Protein marelle

Species

Drosophila melanogaster (Fruit fly)

Protein Length

Partial

Tag Info

Tag type will be determined during the manufacturing process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Form

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Buffer before Lyophilization

Tris/PBS-based buffer, 6% Trehalose.

Reconstitution

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.

Troubleshooting and FAQs

Protein FAQs

Storage Condition

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Lead Time

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Datasheet

Please contact us to get it.

Target Background

Function

Signal transduction and activation of transcription. Plays an important role in the segmental pattern formation in the early embryo by activating specific stripes of pair rule gene expression. The Janus kinase-STAT pathway is connected to drosophila early development.

Gene References into Functions

critical in vivo regulator of glial responsiveness to axonal injury PMID: 25369313
educed Wingless (Wg) signaling dominantly inhibits Stat92E activity in the hinge PMID: 23978534
stat92E activity is regulated along the proximodistal axis to pattern this axis and control the relative expansion of the pouch, hinge, and notum in developing Drosophila PMID: 23499656
modulating STAT activity levels regulates competitor status PMID: 22992954
Loss of Stat92E in the early embryo down-regulates early zygotic genes important for pattern formation. PMID: 21637778
sumoylation has a repressive role in the regulation of the JAK/STAT pathway PMID: 20616536
Characterization of Stat92E that promotes tunmorigenesis in Drosophila is reported. PMID: 20501334
An efficient approach to isolate STAT regulated enhancers uncovers STAT92E fundamental role in Drosophila tracheal development. PMID: 20171201
signal activates the JAK/STAT92E pathway in neighboring epithelial cells, causing them to become invasive. PMID: 11779460
stat92E is necessary for the early differentiation of follicle cells during Drosophila oogenesis PMID: 11846485
Negative regulation of STAT92E by an N-terminally truncated STAT protein derived from an alternative promoter site. PMID: 12231627
Taken together with the appearance of STAT92E in a gradient in the hindgut epithelium, these results support a model in which an anteroposterior gradient of ligand results in a gradient of activated STAT. PMID: 12441298
stat92E mutants are defective in tracheal formation, hindgut elongation, and nervous system development PMID: 14654218
A genetic analysis was made of Stat92E to larval hemocyte concentration and the egg encapsulation response. PMID: 15082553
direct evidence that the JAK/STAT pathway mediates a key signal from the somatic gonad that regulates male germline sexual development PMID: 16049490
STAT signalling controls cell motility during germ cell migration. PMID: 16477645
Study shows that although STAT directly regulates Sxl establishment promoter (SxlPe), it is dispensable for promoter activation, instead, JAK/STAT is needed to maintain high-level SxlPe expression in order to ensure Sxl autoregulation in XX embryos. PMID: 17363251
Study examines the natural DNA-binding sites of the single Drosophila Stat and show that Stat92E is able to bind to and activate target gene expression through palindromic sites separated by spacers of both three or four nucleotides. PMID: 18802449
Genome-wide expression profiling on eye discs in which Stat92E is hyperactivated, revealed 584 differentially regulated genes. PMID: 19504457
STAT92E activity is restricted to hub-proximal germ cells. STAT92E activation appears to be necessary to promote male germline stem cell establishment & for onset of self-renewing GSC divisions. PMID: 19643104
JAK/STAT signaling regulates tissue outgrowth and male germline stem cell fate in Drosophila. PMID: 15686618

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Subcellular Location

Cytoplasm. Nucleus.

Protein Families

Transcription factor STAT family

Database Links

KEGG: dme:Dmel_CG4257

STRING: 7227.FBpp0088489

UniGene: Dm.2627

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Recombinant Drosophila melanogaster Signal transducer and transcription activator (Stat92E), partial

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