Product Details

Purity

>85% (SDS-PAGE)

Target Names

Stim

Uniprot No.

P83094

Alternative Names

Stim; CG9126; Stromal interaction molecule homolog

Species

Drosophila melanogaster (Fruit fly)

Protein Length

Partial

Tag Info

Tag type will be determined during the manufacturing process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Form

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Buffer before Lyophilization

Tris/PBS-based buffer, 6% Trehalose.

Reconstitution

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.

Troubleshooting and FAQs

Protein FAQs

Storage Condition

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Lead Time

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Datasheet

Please contact us to get it.

Target Background

Function

Plays a role in mediating Ca(2+) influx following depletion of intracellular Ca(2+) stores.

Gene References into Functions

These data identify an essential role for STIM in larval dopaminergic cells. PMID: 28131984
after depletion of Ca(2+) stores in Drosophila, translocation of the IP3R to Endoplasmic reticulum-plasma-membrane junctions facilitates the coupling of STIM to Orai that leads to activation of Store-operated Ca(2+) entry. PMID: 27591258
Data indicate that STIM functions as sensors of Ca2+ stored in the endoplasmic reticulum (ER) lumen and translocate into ER-PM (plasma membrane) junctions to tether and activate Orai channels when ER Ca2+ concentration decreases. PMID: 23512988
Induced STIM1 translocation to the plasma membrane promotes intestinal epithelial cell migration after wounding by enhancing TRPC1-mediated Ca2+ signaling and provide new insight into the mechanism of intestinal epithelial restitution. PMID: 20631248
proposal that STIM1 functions as the missing link between Ca2+ store depletion and store-operated calcium influx, serving as a Ca2+ sensor that translocates upon store depletion to the plasma membrane to activate CRAC channels PMID: 16208375
Interaction with the C terminus of Stim thus induces Orai dimers to dimerize, forming tetramers that constitute the Ca(2+)-selective pore. PMID: 18820677
dSTIM regulates growth and patterning of imaginal discs and indicate potential interactions with the Notch and Wingless signaling pathways. PMID: 18950512

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Subcellular Location

Cell membrane; Single-pass type I membrane protein.

Database Links

KEGG: dme:Dmel_CG9126

STRING: 7227.FBpp0073955

UniGene: Dm.172

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Recombinant Drosophila melanogaster Stromal interaction molecule homolog (Stim), partial

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