Recombinant Drosophila melanogaster Transient receptor potential cation channel subfamily A member 1 (TrpA1), partial

1. We show that signalling through the TrpA1 thermo-sensor is required for PMW, and that TrpA1 specifically impacts siesta onset, but not night sleep onset, in response to elevated temperatures. We identify two critical TrpA1-expressing circuits and show that both contact DN1p clock neurons, the output of which is also required for PMW. PMID: 28084307
2. This review discusses the various roles that TRPA1 plays in temperature related behaviors with a main focus on the underlying neuronal circuits. [review] PMID: 28972543
3. Characterization of TRPA1 and RyR demonstrates that Ca(2+) signaling is required for oxidative stress-induced activation of the Ras/MAPK pathway, which in turns drives intestinal stem cell proliferation. PMID: 28561738
4. study shows that activity/rest rhythms are modulated in a temperature-dependent manner via signals from dTRPA1(SH)-GAL4 driven neurons. Taken together, these results emphasize the differential influence of thermoreceptors on rhythmic behavior in fruit flies in coordination with light inputs. PMID: 26868037
5. These findings demonstrate that Drosophila detects bacterial endotoxins via a gustatory pathway through TRPA1 activation as conserved molecular mechanism. PMID: 27296646
6. Collectively, TRPA1 A isoform rapidly responds to natural sunlight intensities through its nucleophile sensitivity as a receptor of photochemically generated radicals, leading to an acute light-induced behavioral shift in Drosophila. PMID: 27656903
7. H2O2-sensitive dTRPA1 isoforms promote avoidance of UV when adult Drosophila females are selecting sites for egg-laying. PMID: 27932542
8. study concludes that the TRPA1 channel is not required for temperature synchronization but instead is required to repress activity during the warm part of the day PMID: 26459465
9. Contribution of Drosophila TRPA1 to Metabolism. PMID: 27055172
10. Citronellal can promote feeding deterrence of fruit flies through direct action on gustatory dTRPA1, revealing the first isoform-specific function for TRPA1(A). PMID: 26447139
11. Recent work has uncovered the Transient Receptor Potential (TRP) channels TRPA1 mediating fly thermosensation. PMID: 25616212
12. temperature sensitive regulation of afternoon peak activity under semi-natural conditions PMID: 26226013
13. results suggest that specific isoforms of dTRPA1 can sense UV light via photochemical production of H2O2 PMID: 26443856
14. reported expression of TrpA1 in clock neurons is unlikely to be involved in generating the summer locomotor profile, suggesting that other TrpA1 neurons are responsible for the A component PMID: 26124142
15. The activation of TRPA1-expressing neurons may differentially coordinate light/dark circadian entrainment, depending on the temperature. PMID: 24367706
16. A 37-amino-acid-long intracellular region (encoded by a single exon) that is critical for dTRPA1 temperature responses. PMID: 22347718
17. This study showed that Drosophila TRPA1 (transient receptor potential cation channel A1) was necessary for normal activity patterns during temperature cycles. PMID: 23595730
18. Residues in the pore region of Drosophila transient receptor potential A1 dictate sensitivity to thermal stimuli PMID: 23027824
19. determination of how thermal vs chemical stimuli activating Drosophila TRPA1 are discriminated PMID: 22139422
20. Cytoplasmic ankyrin repeats of transient receptor potential A1 (TRPA1) dictate sensitivity to thermal and chemical stimuli PMID: 21930928
21. TRPA1 is identified as a conserved regulator of nociception. PMID: 21909389
22. These results suggest that TRPA1 is required for activation of a BK channel to modulate citronellal-evoked action potentials and for aversion to citronellal. PMID: 20797863
23. TRPA1 mediates the Slowly Adapting mechanically-activated currents in small-diameter IB4 negative neurons PMID: 20808441
24. Honeybee TRPA and Drosophila TRPA1 are functionally comparable in Drosophila as a direct, but not indirect, chemical sensor for insect antifeedants. PMID: 20844118
25. found that TRPA1 was expressed in gustatory receptor neurons that respond to aversive compounds. PMID: 20404155
26. The pore of TRPA1 is dynamic and supports a surprisingly large Ca(2+) influx. PMID: 20197030
27. functional comparison with mouse protein PMID: 12815418
28. AC neuron activation occurs just above the fly's preferred temperature and depends on dTrpA1, an ion channel that functions as a molecular sensor of warmth PMID: 18548007
29. We propose that activation of TRPA1 through a signaling cascade promotes amplification of small differences in temperature and facilitates adaptation to temperatures within the comfortable range. PMID: 18660806
30. dTRPA1 is essential for warm avoidance, but not cool avoidance PMID: 18787131
31. suggest that dTRPA1 may be particularly useful for researchers interested in activating fly neural circuits over long time scales. PMID: 19339465

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KEGG: dme:Dmel_CG5751

STRING: 7227.FBpp0304207

UniGene: Dm.15461