Recombinant Human Centriolar coiled-coil protein of 110 kDa (CCP110), partial

1. PLK4 specifically phosphorylates CP110 at the S98 position and is an essential step for centriole assembly. PMID: 28562169
2. This brief communication reports on a patient with an exceedingly rare "8p11 (eight-p-eleven) myeloproliferative syndrome" (EMS) with CEP110-FGFR1 rearrangement who responded to treatment with the multi-tyrosine kinase inhibitor (TKI) dasatinib PMID: 28242791
3. In tissues of prostate cancer patients, low CP110 and high miR-129-3p expression levels correlated with metastasi PMID: 26918338
4. We demonstrated that restoration of CP110 expression in MDA-MB-231 and MCF-7 cells by miR-129 overexpression rendered the cells sensitive to docetaxel. PMID: 26487539
5. Data show thata combining cyclin-dependent kinase 2 (CDK2) antagonism and ubiquitin thioesterase 33 (USP33) depletion augments anaphase catastrophe via changes in centrosomal protein of 110 kDa (CP110) protein expression. PMID: 26304236
6. CP110 plays a mechanistic role in response of lung cancer cells to CDK2 inhibition, especially in the presence of activated KRAS mutations. PMID: 25808870
7. Centrin2 regulates primary ciliogenesis through controlling CP110 levels. PMID: 25753040
8. Both protein and mRNA levels of ciliogenesis-associated markers CP110, Foxj1, TAp73 were significantly increased in patients with nasal polyps versus those seen in control subjects and were positively correlated with cilia length PMID: 25201258
9. using human cells, identification of a new mechanism for the regulation of centrosome duplication that requires USP33, a deubiquitinating enzyme that is able to regulate CP110 levels PMID: 23486064
10. Neurl4 counteracts accumulation of CP110, thereby maintaining normal centriolar homeostasis and preventing formation of ectopic microtubular organizing centres PMID: 22441691
11. miR-129-3p controls cilia assembly by regulating CP110 and actin dynamics. PMID: 22684256
12. Cp110 expression in mucosa from patients with chronic rhinosinusitis might contribute to the poor ciliation observed in these patients PMID: 21982113
13. Study found that loss of Kif24 leads to the disappearance of CP110 from mother centrioles in cycling cells able to form cilia; thus, identifying a centriolar kinesin that specifically remodels a subset of microtubules, thereby regulating cilia assembly. PMID: 21620453
14. SCF(Cyclin F)-mediated degradation of CP110 is required for the fidelity of mitosis and genome integrity PMID: 20596027
15. CP110, a cell cycle-dependent CDK substrate, regulates centrosome duplication (CP110) PMID: 12361598
16. These data demonstrate a functional role for CaM binding to CP110 and suggest that CP110 cooperates with CaM and centrin to regulate progression through cytokinesis. PMID: 16760425
17. CP110 suppresses a cilia assembly program. PMID: 17719545
18. The transition from centrioles to basal bodies is negatively regulated by CP11 protein. PMID: 17765674
19. These results suggest that CEP290 cooperates with Rab8a to promote ciliogenesis and that this function is antagonized by CP110. PMID: 18694559
20. Results suggest that CPAP and CP110 play antagonistic roles in determining the extent of tubulin addition during centriole elongation, thereby controlling the length of newly formed centrioles. PMID: 19481458

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HGNC: 24342

OMIM: 609544

KEGG: hsa:9738

STRING: 9606.ENSP00000370803

UniGene: Hs.279912