Recombinant Human A disintegrin and metalloproteinase with thrombospondin motifs 3 (ADAMTS3), partial

Code CSB-YP001310HU
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Source Yeast
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Code CSB-EP001310HU
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Source E.coli
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Code CSB-EP001310HU-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP001310HU
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Source Baculovirus
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Code CSB-MP001310HU
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Source Mammalian cell
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Product Details

Purity
>85% (SDS-PAGE)
Target Names
ADAMTS3
Uniprot No.
Alternative Names
ADAMTS3; KIAA0366A disintegrin and metalloproteinase with thrombospondin motifs 3; ADAM-TS 3; ADAM-TS3; ADAMTS-3; EC 3.4.24.-; Procollagen II N-proteinase; PC II-NP; Procollagen II amino propeptide-processing enzyme
Species
Homo sapiens (Human)
Protein Length
Partial
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

Customer Reviews and Q&A

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Target Background

Function
Cleaves the propeptides of type II collagen prior to fibril assembly. Does not act on types I and III collagens.
Gene References into Functions
  1. Molecular cloning and in silico analysis identify potential transcription factor binding sites in the ADAMTS3 promoter region and show that SP1 downregulated ADAMTS3 transcriptional activity in osteosarcoma cell lines. As consistent with the transcriptional activity, mRNA, and protein expression levels were also decreased by SP1. PMID: 29518549
  2. Results corroborate the recent in vitro and murine data that suggest a close functional interaction between ADAMTS3 and CCBE1 in triggering VEGFR3 signaling, a cornerstone for the differentiation and function of lymphatic endothelial cells. PMID: 28985353
  3. Findings suggest that these MMP16 rs10090371, ADAMTS3 rs788935, TLL2 rs10882807 and MMP9 rs3918251 may be promising prognostic biomarkers for cutaneous melanoma specific survival (CMSS). PMID: 28796414
  4. The pregnancy loss rate seems to be affected by both ADAMTS-3 and ADAMTS-16. PMID: 28088271
  5. Data indicate that ADAMTS2 and 3 cleave the amino-propeptide of fibrillar collagens and regulate blood vessels homeostasis and lymphangiogenesis. [review] PMID: 25863161
  6. ADAMTS-2, -3, and -13 expression, but not that of ADAMTS-14, are increased in plaques causing AMI compared those associated with stable angina. PMID: 22205175

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Subcellular Location
Secreted. Secreted, extracellular space, extracellular matrix.
Tissue Specificity
Found in cartilage and skin.
Database Links

HGNC: 219

OMIM: 605011

KEGG: hsa:9508

STRING: 9606.ENSP00000286657

UniGene: Hs.590919

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