Recombinant Human Alpha-1-acid glycoprotein 1 (ORM1 AGP1)

1. Studies suggest plasma alpha-1-acid glycoprotein (AAG) as a potential predictive biomarker of docetaxel non-haematological AEs namely oral mucositis and rash. PMID: 28554261
2. Data provide evidence that Orm1 is induced in response to hepatic injury and executes liver regeneration by activating cell cycle progression in hepatocytes. PMID: 28927749
3. Data suggest that serum haptoglobin, fetuin-A, platelet factor-4, hs-CRP (high sensitive-C-reactive protein), SAP (serum amyloid P), AGP (alpha1-acid glycoprotein) levels of adolescents with metabolic syndrome are significantly higher than those of controls subjects. PMID: 27754964
4. Results indicate that advanced extranodal NK/T cell lymphoma (ENKL) patients with unfavourable treatment outcomes displayed higher levels of S100A9 and ORM1. PMID: 27021626
5. Glycosylated Alpha-1-acid glycoprotein 1 is ostensibly expressed in lung cancer patients and is a potential lung cancer serum biomarker. PMID: 26563422
6. Altogether, these results indicate that alpha1-3 fucosylated glycoforms of AGP are increased in PDAC and could be potentially regarded as a PDAC biomarker. PMID: 26563517
7. The results of this study suggest that the expression of VEGF-A and ORM-1 may be associated with two mechanisms (angiogenesis and tumor structural viscosity) that may influence tumor growth in odontogenic myxoma. PMID: 26193215
8. Data suggest that human serum albumin (HSA) might serve as a carrier in delivering chitooligomers to target tissues than alpha-1-glycoprotein (AGP) which has pharmacological importance PMID: 24359035
9. ORM1 stimulates quiescent monocytes to polarize to M2b monocytes. PMID: 25689617
10. Identify ORM genetic variations/haplotype structure associated with serum alpha-1-acid glycoprotein level and the pharmacokinetics of paclitaxel in Japanese cancer patients. PMID: 21638284
11. Data indicate that the band intensity of sialic acid content in alpha-1 Acid glycoprotein (AGP) of alcoholic liver cirrhosis was found to be lower than that in pooled control group. PMID: 25408356
12. These findings suggest that the ORM distal promoter region differentially regulates expression of ORM genes at basal level and in acute phase responses. PMID: 24389491
13. Identified is the ORM1 gene, coding for orosomucoid, as a novel locus associated with lag time variability, reflecting the initiation process of thrombin generation. PMID: 24357727
14. analysing the glycosylation of AGP in patients receiving methadone may aid in determining whether the therapy is likely to be effective. PMID: 23936770
15. The ORM1 A113G polymorphism was associated with the PKs variability after taking telmsiartan, as well as ABCC2 C3972T. The heterozygotes of ORM1 113AG showed a larger AUC and a notable BP change(%) from the baseline compared with the wild-type. PMID: 23940561
16. The ORM1 may be considered as a signaling molecule involved in the maintenance of tissue homeostasis and remodeling. PMID: 23973664
17. A cross-sectional study was conducted to evaluate the relationship between periodontitis and the common systemic inflammatory markers in 32 morbidly obese patients. The severity of periodontitis was associated with the plasma level of orosomucoid. PMID: 23526947
18. Drug-binding energetics of human alpha-1-acid glycoprotein. PMID: 23192962
19. AGP has a direct effect in brain microvasculature and may play an important role in altering blood brain barrier integrity in inflammatory-related diseases. PMID: 22633841
20. alpha(1)-Acid glycoprotein up-regulates CD163 via TLR4/CD14 protein pathway: possible protection against hemolysis-induced oxidative stress. PMID: 22807450
21. change of the maintenance of three acute phase proteins: ceruloplasmin, alpha1-antitripsin and orosomucoid in an oral fluid and blood plasma at paradontitis and myocardial infarction PMID: 22708402
22. Analyses of Nicaraguan population surveillance data suggest that preschool children with elevated AGP1 levels have higher prevalence of anemia than children with normal AGP1 levels. PMID: 22908695
23. The binding properties of the polymyxin class of antibiotics for human alpha-1-acid glycoprotein (AGP) have been characterized. PMID: 22587817
24. Urinary MCP1 and AGP are biomarkers of lupus nephritis in patients with juvenile-onset systemic lupus erythematosus, providing insight into its pathophysiology PMID: 22147846
25. Characterization of 6-mercaptopurine binding site on human alpha1-acid glycoprotein (orosomucoid) using molecular docking. PMID: 22574522
26. Leukocytospermia was associated with the alterations of terminal monosaccharide expression in human seminal fibronectin and alpha{1}-acid glycoprotein PMID: 22048274
27. In this study, the potential of CZE-UV and CZE-ESI-MS analysis of intact AGP isoforms to study the correlation of this protein with bladder cancer is shown. PMID: 22216449
28. Importance of pH and disulfide bridges on the structural and binding properties of human alpha-acid glycoprotein. PMID: 21621584
29. Data suggest that GDC-0449 pharmacokinetics are mediated by AAG binding. PMID: 21300760
30. The distribution of the AGP phenotypes did not differ significantly among the disease groups studied PMID: 21726491
31. analysis of differences in drug-binding selectivity between two forms of human alpha1-acid glycoprotein genetic variants, the A and F1*S forms PMID: 21349832
32. Characterized are more than 150 human Alpha-1-acid glycoprotein isoforms, differing both in the amino acid sequence and in the glycosylation. PMID: 20617306
33. Almost all of the acute-phase proteins were closely related to rheumatoid arthritis activity (based on DAS28) and their places in the downgrade scale were as follows: CRP, Tf, AGP, Hp and AAT. PMID: 20371432
34. ORM integrates inflammatory and metabolic signals to modulate immune responses to protect adipose tissue from excessive inflammation and thereby from metabolic dysfunction. PMID: 20442402
35. ORM1*S/*S genotype predicted failure to complete a 6-week trial of antidepressants, whereas elevated plasma concentration of orosomucoid predicted failure to respond to antidepressant therapy at 6 weeks. PMID: 19395425
36. The present study investigated enhanced fucosylation of AGP in the sera of chronic hepatitis B (HBV-CH) and hepatitis B cirrhosis (HBV-LC) patients. PMID: 19459043
37. A site-directed mutagenesis study of drug-binding selectivity in genetic variants of AGP1 is reported. PMID: 19198000
38. Different ORM1 phenotypes may affect the disposition of quinidine PMID: 11814462
39. demonstrate that orosomucoid and/or its glycoforms affects thyroid cell function in vitro and that it does so by influencing the second messenger cAMP probably by interacting directly with the TSH receptor PMID: 11911961
40. The effect of alpha2,6-linked sialic acid on anti-IgM antibody-induced apoptosis in Ramos cells. PMID: 11925509
41. folds as a highly symmetrical all-beta protein dominated by a single eight-stranded antiparallel beta-sheet PMID: 12480518
42. exerts significant effects on the pharmacokinetics, plasma concentrations, and intracellular distribution of imatinib in chronic myeloid leukemia patients PMID: 12576428
43. tertiary structure analysis PMID: 15013397
44. Urinary levels are increaed in normoalbuminuric type 2 diabetic patients. PMID: 15111541
45. the N-linked glycosylation pattern of AGP was explored PMID: 16261636
46. The binding of coumarin enantiomers to ORM1 is studied. PMID: 16290938
47. The drug binding site of AGP was gained from circular dichroism and electronic absorption spectra. PMID: 17321687
48. Alpha-1-acid glycoprotein 1 may be an endogenous ligand for Siglec-5 as a signaling molecule that participates directly in the regulation of neutrophil responses. PMID: 17675532
49. Different ORM1 genotypes affect the protein binding percentage and the concentration of serum free nortriptyline. PMID: 17944232
50. A different distribution of the area percentage of AGP forms is observed when comparing samples from diseased and healthy individuals, the most acidic AGP forms being present in a higher proportion in the samples from cancer patients. PMID: 17987628

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HGNC: 8498

OMIM: 138600

KEGG: hsa:5004

STRING: 9606.ENSP00000259396

UniGene: Hs.522356