Recombinant Human Attractin (ATRN), partial

Code CSB-YP002435HU
MSDS
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Source Yeast
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Code CSB-EP002435HU
MSDS
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Source E.coli
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Code CSB-EP002435HU-B
MSDS
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP002435HU
MSDS
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Source Baculovirus
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Code CSB-MP002435HU
MSDS
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Source Mammalian cell
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Product Details

Purity
>85% (SDS-PAGE)
Target Names
ATRN
Uniprot No.
Alternative Names
ATRN; ATRN_HUMAN; attractin 2 ; Attractin; DPPT L; DPPT-L; KIAA0548; Mahogany homolog; mahogany protein ; Mahogany, mouse, homolog of; MGCA
Species
Homo sapiens (Human)
Protein Length
Partial
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose.
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

Customer Reviews and Q&A

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Target Background

Function
Involved in the initial immune cell clustering during inflammatory response and may regulate chemotactic activity of chemokines. May play a role in melanocortin signaling pathways that regulate energy homeostasis and hair color. Low-affinity receptor for agouti. Has a critical role in normal myelination in the central nervous system.
Gene References into Functions
  1. ATRN encodes Attractin, which was previously shown to play a critical role in central myelination PMID: 28493104
  2. Data indicate that Attractin was involved in male reproduction in both human and BALB/c mice, but it exerted a different expression profile in different species. PMID: 25318887
  3. The levels of both dipeptidyl-peptidase 4 and attractin in circulating monocytes were significantly higher in obese subjects as compared with levels in lean controls or in subjects with type 2 diabetes. PMID: 20198559
  4. associated with spermatozoa PMID: 19535787
  5. This protein is isolated from human blood and characterized. PMID: 12675230
  6. It is the first time expression of attractin on monocytes and provide first data suggesting that drugs directed to DP IV-like enzyme activity could affect monocyte function via attractin inhibition. PMID: 16835316
  7. The product of the murine "Mahogany" gene controls energy metabolism and is the murine orthologof human membrane attractin. PMID: 10086355
  8. Through use of PCR from hamster-human somatic cell hybrids, localizes the EST AB011120 (KIAA0548) to human chromosome 20p13. AB011120 encodes the central to 3' UTR of the membrane form of human attractin. PMID: 9628581
  9. The product of the murine "Mahogany" locus, controlling agouti-mediated melanocyte pigmentation and control of energy metabolism, is the murine ortholog of human attractin. PMID: 10086356
  10. Provides the genomic basis for production of a soluble and membrane form of attractin by alternative splicing. In the process, by sequencing from positionally-determined BAC clones, confirms the localization of attractin to chromosome 20p13. PMID: 10811918

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Subcellular Location
[Isoform 1]: Cell membrane; Single-pass type I membrane protein.; [Isoform 2]: Secreted.; [Isoform 3]: Secreted.
Tissue Specificity
Isoform 2 is detected in plasma (at protein level). Expressed and secreted by activated T-lymphocytes. Expressed at low to moderate levels in peripheral blood leukocytes, spleen, lymph node, tonsil, bone marrow and fetal liver. At very low levels found in
Database Links

HGNC: 885

OMIM: 603130

KEGG: hsa:8455

STRING: 9606.ENSP00000262919

UniGene: Hs.276252

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