Recombinant Human Basigin(BSG),partial

1. ectopic CD147-polarized distribution on basolateral membrane promotes hepatocyte depolarization by activation of the CD147-integrin alpha5beta1-E-cadherin ubiquitination-partitioning defective 3 decrease and beta-catenin translocation signaling cascade, replenishing a molecular pathway in hepatic carcinogenesis PMID: 29356040
2. CD147 and the beta2-adrenergic receptor form hetero-oligomeric complexes.Actinin-4 directly binds to the cytosolic tail of CD147 and governs the assembly of CD147-beta2-adrenergic receptor complexes in highly ordered clusters at bacterial adhesion sites. PMID: 28569760
3. Plasma sCD147 levels are elevated in breast cancer patients. Soluble CD147 is also associated with tumour size, lymph node metastasis, high recurrent risk, and chemoresistance. PMID: 29807951
4. overexpression of CD147 may promote OSF progression. PMID: 29457855
5. these findings show that CD147 is a novel and key mediator of IL-22-induced psoriatic alterations in the epidermis and might be a therapeutic target in patients with psoriasis. PMID: 28272440
6. Data indicate that CD147 promotes breast cancer cell proliferation, metastasis, and invasion by modulating matrix metalloproteinase 9 (MMP-9) and vascular endothelial growth factor (VEGF) expression. PMID: 29901696
7. BSG expression is indicative of a poor prognosis in pulmonary adenocarcinoma PMID: 29431238
8. CD147 expression was associated with clinicopathological features and biomarkers related to triple-negative breast cancer, particularly basal-like breast cancer. PMID: 30099407
9. Characterization of the role of CD147 in the development of tumors should lead to a better understanding of the changes occurring at the molecular level during the development and progression of primary human bone cancer. PMID: 30043854
10. Results find CD147 expression level increased in colorectal cancer (CRC) tumors and cell lines and inversely correlated with mir-485 expression. Also, CD147 is a target gene of miR485 which negatively regulates its gene expression. PMID: 29532886
11. Our results indicate that concomitant stimulation and colocalization of galectin-3 with CD147 are associated with increased gelatinolytic activity in the actively ulcerating human cornea PMID: 29340650
12. These findings reveal an important cytomegalovirus mechanism for evading antiviral innate immunity through its encoded microRNA US25-1-5p by targeting transmembrane glycoprotein CD147. PMID: 29194430
13. on a major part of fibroblastic cells in encapsulating peritoneal sclerosis PMID: 28551820
14. Review: Bsg is an extracellular receptor for CyPA that promotes cell proliferation and inflammation. Thus, the CyPA/Bsg system is potentially a novel therapeutic target for cardiovascular diseases. PMID: 28993547
15. protein-protein interaction studies on TRAF6 and BSG to get molecular level insights of the reactions. PMID: 28612997
16. results showed that the rs4919862 SNP of CD147 was closely associated with carotid atherosclerotic plaques formation; thus, polymorphisms of the CD147 gene may be related to the tendency for carotid atherosclerotic plaques PMID: 28582638
17. Results indicated that higher expression of CD147/EMMPRIN potentially may be a prognostic marker for most cancers. CD147/EMMPRIN overexpression predicted a high risk for chemotherapy drugs resistance. CD147/EMMPRIN is a central player in tumor progression and predicts a poor prognosis. [review] PMID: 27608940
18. BSG mutation is associated with early-onset high myopia. PMID: 28373534
19. Cancer cells and fibroblasts interaction promotes breast cancer cells showing stem-like cell properties through up-regulation of EMMPRIN. PMID: 27325313
20. Cholesterol depletion inhibits the endocytosis of CD147 but that the constitutive shedding of CD147 mediated by ADAM10 is enhanced. PMID: 28703811
21. Overexpression of CD147 support the metabolic reprograming in papillary renal cell carcinoma PMID: 28028797
22. This research found that CD147 is correlated with aggressiveness of the glioma, tumor grades, tumor size, necrosis, overall survival, and recurrence rate. PMID: 28560663
23. Upregulation of CD147 Promotes Metastasis of Cholangiocarcinoma by Modulating the Epithelial-to-Mesenchymal Transitional Process PMID: 28244853
24. Our retrospective analysis demonstrated CD147 protein expression was significantly associated with clinical N stage, and tumor stage. Meanwhile, it can also serve as an independent prognosis biomarker. PMID: 28427166
25. miR-492 may be involved in the regulation of OK antigen expression on red blood cells with the BSG rs8259 TT genotype. PMID: 28981932
26. Our findings show that emmprin is released through microvesicle shedding in sarcoma cells, and emmprin in microvesicles regulates MMP-2 production by influencing the activity of fibroblasts located at sites distant from the tumor cells. PMID: 28498412
27. enhancement of the effect of trastuzumab on HER2-positive cells following CD147 knockdown might be attributed to increased apoptosis and decreased phosphorylation of signaling proteins PMID: 27363028
28. this study shows that CD147 silencing inhibits tumor growth by suppressing glucose transport in melanoma PMID: 27556188
29. Fucosylation of CD147 by Lewis y antigen enhanced the survival ability by promoting basic autophagy activity and restraining autophagic cell death in ovarian cancer. PMID: 27863372
30. Review/Meta-analysis: up-regulation of CD147 was effectively predictive of worse prognosis in gastrointestinal cancer. PMID: 27768590
31. Suggest a central role for CD147 in pancreatic cancer metabolic reprogramming, particularly with respect to amino acid anabolism and calcium signaling. PMID: 28039486
32. combined CA9-/CD147-capture antibodies demonstrated high efficiency for capturing circulating renal cell carcinoma cells PMID: 27494883
33. important factor in the aggressive behaviour of melanoma PMID: 27060463
34. Xkr8-BSG/NPTN complex is required for phosphatidylserine scrambling in apoptotic cell membranes. PMID: 27503893
35. Our study provides new evidence that interaction of KLF6 and Sp1 regulates basigin-2 expression in hepatocellular carcinoma PMID: 27057625
36. EMMPRIN/MMPs/VEGF pathway is involved in PDR angiogenesis. PMID: 27860331
37. study identified novel interactions between CD147 and RING1, recovered CD147 nuclear envelope distribution in melanoma cells, and suggested a new mechanism underlying how cytoplasmic CD147 promotes melanoma development PMID: 28832687
38. Immunohistochemistry was employed to analyze cFos, cJun and CD147 expression in 41 UCB cases and 34 noncancerous human bladder tissues. PMID: 28358415
39. High BSG expression is associated with multiple myeloma. PMID: 28017969
40. report that a phosphoserine (pSer) in CD147 (pSer252) is responsible for this interaction and inhibition of the Smad4/p21(WAF1) signal that promotes cell proliferation PMID: 28684116
41. findings indicate that Rab22a enhances recycling of CD147, which is required for lung cancer cell migration and invasion,and targeting CD147 recycling may be a rational strategy for lung cancer therapy PMID: 28433697
42. Studied expression of CD147 in both ALK+ and ALK- anaplastic large-cell lymphoma; found CD147 to be a downstream target for activation by C/EBPbeta. PMID: 28581487
43. this studies identify potential signaling routes of CD147 affecting T cell growth and function PMID: 28148733
44. Our results highlight the important role of the TGF-beta1-CD147 self-sustaining network in driving HCC development by regulating differentiation plasticity, which provides a strong basis for further investigations of the differentiation therapy of HCC targeting TGF-beta1 and CD147. PMID: 27041581
45. rs8259 polymorphism failed to exhibit an association with cardiovascular mortality (p = 0.283). BSG rs8259 polymorphism may contribute to decreased risk of Chronic Heart Failure in a Chinese Han population PMID: 28230811
46. This study suggests that CD44 and CD147 together improve the prognostic efficacy of tumor differentiation; in vitro results further point out that these markers might be determinant of differentiation characteristics, imparting properties of increased self-renewal, migration, and invasion. PMID: 28631562
47. Results suggest that CD147 promotes chemoresistance by activating MAPK/ERK signaling pathway in head and neck squamous cell carcinoma (HNSCC). PMID: 28062212
48. PvTRAg38 binds to two erythrocyte receptors basigin and band 3 through P2 and P4 regions, respectively, to facilitate parasite growth. PMID: 27881677
49. phosphatidylinositol 3-kinase/Akt pathway may be the probable signaling pathway underlying CD147 induced up-regulation of VEGF in U937-derived foam cells PMID: 27619643
50. D147 expression is potentially closely related to Hepatocellular Carcinoma survival and associated clinicopathological parameters, paving the way for further research PMID: 28386553
51. Data show that FBXO22 mediated the polyubiquitination and degradation of CD147 by interacting with CD147 intracellular domain (CD147-ICD). PMID: 28117675
52. EMMPRIN may be a valuable immunohistochemical marker for differentiating LMS from benign smooth muscle tumors in problematic cases. PMID: 26352545
53. CD147 promotes the 5-Fluorouracil (5-FU) resistance, and MAPK/ERK signaling pathway is involved in CD147-promoted invasion and EMT of CRC cells. PMID: 25550778
54. EMMPRIN may have a role in acute myocardial infarction and stable coronary artery disease PMID: 27439686
55. This study identified that combination of nadroparin and irradiation had a strong synergistic antitumor effect in a dose- and time-related manner in vitro, which was reflected in the inhibition of cell viability, invasion and metastasis, promotion of apoptosis, inhibited secretion level of TGF-beta1 and downregulation of CD147, MMP-2 and survivin expression. PMID: 27498922
56. in cultured H9C2 cells and that CyPA/CD147 signaling pathway inhibition protects against Ang II-induced cardiomyocyte hypertrophy. PMID: 27590243
57. CD147 was significantly upregulated in the human glioma cell lines. Downregulation of CD147 suppressed cell proliferation, blocked cell cycle, induced apoptosis, inhibited cell invasion and angiogenesis in glioma cells in vitro. CD147 was significantly associated with WHO tumor grade and angiogenesis; silencing of CD147 contributed to inhibition of glioma proliferation, invasion and angiogenesis. PMID: 27761842
58. rs11473 polymorphism at the miR- 483-5p binding site in the 3'-UTR of basigin gene may play a key role in the development of esophageal cancer in a Chinese population. PMID: 27420938
59. findings of this research defined a novel relationship between the down-regulation of miR-22 and the up-regulation of CD147 and demonstrated that CD147 is a downstream factor of miR-22. PMID: 26943814
60. Triptolide represses the migration and invasion of prostate cancer cells through Cav-1/CD147/MMPs signalling pathway. PMID: 27847199
61. Basigin is important in vision, spermatogenesis and other physiological phenomena, and plays significant roles in the pathogenesis of numerous diseases, including cancer. Basigin is also the receptor for an invasive protein RH5, which is present in malaria parasites. PMID: 26684586
62. The present study indicated that Slug and EMMPRIN are potential biomarkers and therapeutic targets for the diagnosis and treatment of perineural invasion in human salivary adenoid cystic carcinoma. PMID: 26349748
63. High expression of EMMPRIN plays a crucial role in breast cancer cell proliferation, matrigel invasion and tumor formation. PMID: 27434292
64. CD147 promoted the differentiation of Th17 cells by regulation of cytokine production, which provided the evidence for pathogenesis and potential therapeutic targets for rheumatoid arthritis. PMID: 27859685
65. Study identified CD147 as a novel interaction partner for E2F1 and suggest a role in promoting tumor cell invasion and migration of prostate cancer cells. PMID: 26891801
66. High BSG expression is associated with melanoma invasion and metastasis. PMID: 26769849
67. High CD147 promotes liver tumor cell movement and metastasis via direct interaction with Annexin A2 and DOCK3-beta-catenin-WAVE2 signaling axis. PMID: 26716413
68. EMMPRIN expression is involved in the development of interstitial fibrosis and tubular atrophy in human kidney allografts. PMID: 26659824
69. High CD147 expression was significantly associated with tumorigenicity of Kaposi's sarcoma-associated herpesvirus infected endothelial cells. PMID: 26675551
70. CD147 also participates in inflammation, nutrient and drug transporter activity, microbial pathology and developmental processes PMID: 26604323
71. CD147 is resistant to tumor necrosis factor-induced apoptosis by promoting IKK/IkappaB/NF-kappaB pathway, and the extracellular portion of CD147 is the functional region. PMID: 26296700
72. MCT1 expression was not clearly associated with overall or disease-free survival. MCT4 and CD147 expression correlate with worse prognosis across many cancer types. These results warrant further investigation of these associations PMID: 26779534
73. CD147 is increased in hepatocellular carcinoma cells under starvation and reduces cell death through upregulating mTOR in vitro. PMID: 26496775
74. EMMPRIN, MMP8, hyaluronan, beta-defensing-2, and neutrophil gelatinase-associated lipocalin (NGAL) are elevated in women with vaginal inflammation PMID: 26773532
75. malignant proliferation of human breast cancer MCF-7 cells was significantly inhibited after silencing of the EMMPRIN gene using RNAi, and cells in the G1/G0 and G2/M phases were increased. PMID: 26634540
76. High CD147 expression is associated with multiple myeloma. PMID: 26202926
77. role of CD147 in the regulation of lipid metabolism, including de novo lipogenesis and fatty acid beta-oxidation, in hepatocellular carcinoma cells PMID: 26282231
78. both EGFR and EMMPRIN proteins are potential targets for cancer therapy and EMMPRIN can be used as a prognostic marker of a more aggressive biological behavior in patients with head and neck squamous cell carcinoma PMID: 26296920
79. The cHAb18 was produced in rNDV-18HL-infected cells followed by releasing into the supernatant by cytolysis. The rNDV-18HL-encoded cHAb18 antibody kept affinity for CD147 and showed inhibiting the migration and invasion of hepatocellular carcinoma cells PMID: 26689432
80. these results reveal that CD147 functions as a critical regulator of endoplasmic reticulum -dependent [Ca2+]i oscillations to promote oncogenic progression in hepatocellular carcinoma PMID: 26498680
81. Prognostic significance of CD147 protein expression could not surpass that of MCT4, especially of SLC16A3 DNA methylation, corroborating the role of MCT4 as prognostic biomarker for ccRCC. PMID: 26384346
82. results suggest that CD147 plays an important role in colorectal cancer stem cells PMID: 26316167
83. EMMPRIN promoted metastasis and the epithelial-mesenchymal transition in esophageal cancer cells by regulating HIF-1alpha. PMID: 26458866
84. provide new evidence that HAb18G/CD147-mediated cell-cell contact confers anoikis resistance in an E-cadherin-dependent manner PMID: 20398401
85. We conclude that recombinant adenovirus-mediated siRNA targeting CD147 based on the IGF2 LOI system inhibited the growth of the LOI cells in vitro and in vivo, which would provide a novel approach for targeted CRC gene therapy. PMID: 26397886
86. The authors identified two new human proteins that interact with Ehrlichia chaffeensis EtpE-C: CD147 and heterogeneous nuclear ribonucleoprotein K (hnRNP-K). PMID: 26530384
87. Disruption of BASIGIN in tumour cells and in MEFs has no action on the production of MMPs. PMID: 26284589
88. Basigin facilitates the membrane distribution of CD98 to promote hepatocellular carcinoma cell spreading and tumorigenicity. PMID: 26437640
89. Report CD147 expression in giant cell tumor of bones. PMID: 26339416
90. Results show that CD147 expression is significantly decreased in prostate cancer tissue and is associated with tumor progression. Low CD147 expression is an independent marker that can predict biochemical recurrence after prostatectomy. PMID: 26209327
91. There is a role of EMMPRIN in tumor cell migration through ss1 integrin/kindlin-3-mediated adhesion pathway. PMID: 25807898
92. CD147 is a novel coreceptor of VEGFR-2 with a role in mediating its activation by VEGF PMID: 25825981
93. employed a recombinant soluble, fully glycosylated EMMPRIN domain (rhsEMN) as a tool to characterize the structural basis of EMMPRIN-EMMPRIN receptor contacts and their functional effects on MCF-7 breast carcinoma cells PMID: 26277583
94. interaction of rmEMMPRINex with U937 cells leads to inhibition of MCT1 membrane expression, intracellular activation of procaspase-9, followed by DNA fragmentation and apoptosis. PMID: 26024713
95. Extracellular CyPA activates platelets via cluster of differentiation 147-mediated phosphoinositid-3-kinase/Akt-signaling, leading to enhanced adhesion and thrombus formation independently of intracellular CyPA. PMID: 25550208
96. Data indicate that EMMPRIN is highly expressed in different regions of the mammalian brain, and is up-regulated in several central nervous system disorders. prompting targeting EMMPRIN as a measure to resolve pathology. {review] PMID: 25644103
97. EMMPRIN (CD147) is upregulated on monocyte subsets in patients with acute myocardial infarct as compared to patients with stable coronary artery disease PMID: 25824988
98. S100P expression in prostate cancer tissue was significantly decreased, whereas CD147 and OCT4 expression was increased. Their expression levels were closely associated with TNM stage and distant metastasis. PMID: 26125892
99. Collectively, our results suggest that a Sp1-CD147 positive feedback loop plays a critical role in the invasion ability of ovarian cancer cells. PMID: 25998266
100. miR-485-5p represses hepatocellular carcinoma invasive and metastatic capacities by targeting EMMPRIN expression. PMID: 26054676

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HGNC: 1116

OMIM: 109480

KEGG: hsa:682

STRING: 9606.ENSP00000333769

UniGene: Hs.501293