Recombinant Human Bcl-2-binding component 3, isoforms 3/4 (BBC3)

1. Apoptosis pathways are impaired in fibroblasts from patients with SSc, leading to chronic fibrosis. Nonetheless, PUMA/p53 pathway may not be involved in dysfunction of apoptosis mechanisms in fibroblasts of patients with SSc. PMID: 28905491
2. PUMA promotes the cytosolic release of mitochondrial DNA and activation of the DNA sensors DAI/Zbp1 and STING, leading to enhanced RIP3 and MLKL phosphorylation in a positive feedback loop. PMID: 29581256
3. miR222 inhibitor exerted anticancer effects against liver cancer cells, probably by targeting the 3' untranslated region (UTR) of BBC3. PMID: 29693134
4. PAK1 is upregulated in cutaneous T cell lymphoma. PAK1 silencing induced apoptosis and inhibited cell growth by stimulating the expression of PUMA and p21. PMID: 29307600
5. ERK1/2/p53/PUMA signaling axis is related to cisplatin-induced cell death in ovarian cancer cells. PMID: 28287251
6. these results establish a critical role of PUMA in mediating the anticancer effects of deguelin in lung cancer cells and provide the rationale for clinical evaluation. PMID: 29030732
7. AGG is also found to trigger ubiquitination of PUMA which in turn interacted with p62 for prompting mitophagy suggesting that AGG turns on PUMA-mediated mitophagy in U87MG cells in both p62-dependent as well as in p62-independent manner PMID: 29229477
8. Low PUMA expression is associated with cancer. PMID: 29533771
9. Altogether, these findings suggest that in normal/high glucose condition a mutual unbalance between p53-dependent apoptosis (PUMA) and autophagy (DRAM) gene occurred, modifying the ADR-induced cancer cell death in HG both in vitro and in vivo. PMID: 28893313
10. Data suggest that H2O2 regulates cell death in granulosa cells via the ROS-JNK-p53 pathway. PMID: 28445976
11. Collectively, our findings strongly suggest targeting miR-155 exhibited in vivo and in vitro antileukemic activities in acute myelogeneous leukemia through a novel mechanism resulting in inhibition of Slug expression and increase of PUMA expression. PMID: 27786352
12. these results establish a critical role of PUMA in mediating the anticancer effects of pazopanib in colon cancer cells and provide the rationale for clinical evaluation. PMID: 27924057
13. Concurrent knock-down of Puma reverses Bcl-xl-induced caspase activation. Puma is required for Bclxl-induced cell death. PMID: 28012060
14. Knockdown of Slug enhanced the antitumor activity of DOX in SW1736 cells via induction of PUMA upregulation. Our results suggest that targeting of Slug has good potential for the development of new therapeutic strategies for Anaplastic thyroid carcinoma. PMID: 28128736
15. Results show that PUMA expression is downregulated at the translational level by miR-3196 which inhibits lung cancer cells apoptosis. PMID: 27780918
16. Inhibition of GART induced cellular apoptosis and suppressed the migration of intestinal epithelial cells through the activation of the MEKK3-MKK3-p38 mitogen-activated protein kinase (MAPK) pathway, following with the dys-regulation of p53 and PUMA. PMID: 27718035
17. EZH2 directly binds to the Puma promoter thus epigenetically repressing PUMA expression in non-small cell lung cancer cells. PMID: 27472460
18. Low BBC3 expression is associated with bone marrow metastasis in neuroblastoma. PMID: 28921546
19. findings suggest that PUMA would be involved in the possible crosstalk between the ER and the mitochondria in the homocysteine-induced apoptosis of caspase-4 deficient SH-SY5Y cells. PMID: 27339788
20. Data show that targeting of synoviocytes by a vector, consisting of a baculovirus conjugated to an adenovirus carrying the pro-apoptotic gene PUMA, has therapeutic efficacy in a rat arthritis model. PMID: 28747638
21. In the mouse model of silicosis, Bbc3 knockout mice clearly exhibited decreased levels of autophagy and fibrosis progression. These results suggest that downregulation of BBC3 expression may become a novel therapeutic strategy for the treatment of silicosis. PMID: 28277537
22. Quantitative real-time PCR analysis indicated higher expression of PUM in renal cell carcinoma tissues compared to that in para-carcinoma tissues. PMID: 28692117
23. we have demonstrated that miR-503-5p expression negatively correlates with PUMA expression in colorectal carcinoma cells. PMID: 28423513
24. data suggest that PUMA cooperates with p21 to regulate normal acinus formation and epithelial-to-mesenchymal transition. PMID: 23805223
25. Results show that in PUMA protein adenovirus-infected A2780s ovarian cancer cells, exogenous PUMA was partially accumulated in the cytosol and mainly located to the mitochondria. PMID: 28423586
26. These results demonstrated the involvement of BBC3/Bbc3 in cold preservation/rewarming-mediated islet injury, possibly through modulating HMGB1- and oxidative stress-mediated injury to islets. PMID: 27117005
27. miR-23a-3p, miR-23b-3p, and miR-149-5p, were downregulated by cytokines and selected for further studies. These miRNAs were found to regulate the expression of the proapoptotic Bcl-2 proteins DP5 and PUMA and consequent human beta-cell apoptosis. PMID: 27737950
28. Our results revealed that Slug siRNA transfection in combination with radiation increased the expression of PUMA, which contributed to radiosensitivity of oral squamous cell carcinoma cells PMID: 27277529
29. p53 and Bax might play an important role in microcystin-LR (MC-LR)-induced apoptosis in HepG2 cells in which PUMA and survivin were involved. PMID: 27235693
30. Therapeutic response to non-genotoxic activation of p53 by Nutlin3a is driven by PUMA-mediated apoptosis in lymphoma cells. PMID: 26904937
31. p53/PUMA expression in human pulmonary fibroblasts mediates cell activation and migration in silicosis PMID: 26576741
32. Suggest that the accumulation of PUMA in the cytosol may be important for the participation of this protein in apoptosis without the need for prior transcription in Burkitt's lymphoma b cells. PMID: 26431330
33. in vitro OGT knockdown induced more cell apoptosis through increasing PUMA and caspase-3 expression PMID: 26397041
34. our data purport that p53 not only increased Puma expression directly, but that it may also do so through miR-203. Additionally, functional studies revealed that miR-203 overexpression induced apoptosis and inhibited cell invasiveness. PMID: 26397233
35. the selective degradation of BBC3 underlies the prosurvival role of chaperone-mediated autophagy. PMID: 26212789
36. puma-mediated apoptosis is not induced in mucosal melanomas by cisplatin PMID: 25831048
37. There-fore, stable transfection of PUMA can significantly enhance epirubicin-induced apoptosis sensitivity of MCF-7 breast cancer cells. PMID: 26125773
38. inhibition of AKT/FoxO3a signaling may contribute to H1-mediated PUMA induction, suggesting that inhibition of AKT/FoxO3a signaling result in PUMA expression in response to p53-independent cytotoxic effects of H1. PMID: 25893985
39. Beta-arrestin 2 promotes inflammation-induced intestinal epithelial apoptosis through endoplasmic reticulum stress/PUMA in colitis. PMID: 25354317
40. Puma is the major mediator of virus-induced Bax/Bak activation and mitochondrial membrane permeabilization induction. PMID: 26030884
41. Decrease of survivin expression and induction of PUMA expression. PMID: 25895606
42. Loss of PUMA is associated with lung cancer. PMID: 25684518
43. Slug inversely regulated PUMA and p53 expression in both CNE-2 and CNE-2-RES cells. PMID: 25812964
44. Chk1 activity is required for BAK multimerization in association with PUMA during mitochondrial apoptosis PMID: 25012639
45. PUMA is silenced in bladder cancer by miR-221. PMID: 25585941
46. PUMA protein in p53 regulatory molecule pattern determines the prognosis for patients with lymphoproliferative diseases. PMID: 24824714
47. Taken together, our results indicate that DNA damage resistance in RCC is reversible, involves the p53-PUMA axis, and is potentially targetable to improve the oncological outcomes of RCC patients. PMID: 25499216
48. The present study explored the role and mechanism of miR-222 in increasing the expression of p53 up-regulated modulator of apoptosis (PUMA) and enhancing the sensitivity of oral squamous cell carcinoma to cisplatin. PMID: 25474084
49. PUMA expression increases further during transformation while the expression of p53 is not significantly altered which suggests that PUMA alterations might be a late event during the evolution of myelodysplastic syndromes. PMID: 25846496
50. caspase-9 mediates Puma activation to determine the threshold for overcoming chemoresistance in cancer cells. PMID: 25356864

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HGNC: 17868

OMIM: 605854

KEGG: hsa:27113

STRING: 9606.ENSP00000404503

UniGene: Hs.467020