Recombinant Human Beclin-1-like protein 1(BECN1L1)

Code CSB-YP427931HU
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Source Yeast
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Code CSB-EP427931HU
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Source E.coli
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Code CSB-EP427931HU-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP427931HU
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Source Baculovirus
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Code CSB-MP427931HU
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Source Mammalian cell
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Product Details

Purity >85% (SDS-PAGE)
Target Names BECN2
Uniprot No. A8MW95
Alternative Names BECN2; BECN1L1; BECN1P1Beclin-2; Beclin-1 autophagy-related pseudogene 1; Beclin-1-like protein 1
Species Homo sapiens (Human)
Expression Region 1-431
Target Protein Sequence MSSIRFLCQR CHQALKLSGS SESRSLPAAP APTSGQAEPG DTREPGVTTR EVTDAEEQQD GASSRSPPGD GSVSKGHANI FTLLGELGAM HMLSSIQKAA GDIFDIVSGQ AVVDHPLCEE CTDSLLEQLD IQLALTEADS QNYQRCLETG ELATSEDEAA ALRAELRDLE LEEARLVQEL EDVDRNNARA AADLQAAQAE AAELDQQERQ HYRDYSALKR QQLELLDQLG NVENQLQYAR VQRDRLKEIN CFTATFEIWV EGPLGVINNF RLGRLPTVRV GWNEINTAWG QAALLLLTLA NTIGLQFQRY RLIPCGNHSY LKSLTDDRTE LPLFCYGGQD VFLNNKYDRA MVAFLDCMQQ FKEEAEKGEL GLSLPYGIQV ETGLMEDVGG RGECYSIRTH LNTQELWTKA LKFMLINFKW SLIWVASRYQ K
Protein Length full length protein
Tag Info The following tags are available.
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form Lyophilized powder
Buffer before Lyophilization Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting
and FAQs
Protein FAQs
Storage Condition Store at -20°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet Please contact us to get it.

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Target Data

Function Involved in 2 distinct lysosomal degradation pathways
Gene References into Functions
  1. Further data showed that reactive oxygen species-c-Jun activation by HBx resulted in the release of beclin-1 from its association with beclin-2 to form a complex with VPS34, thus enhancing autophagosome formation. PMID: 28515304
  2. polar BECN2 CCD interface residues result in a metastable homodimer, facilitating dissociation, but enable better interactions with polar ATG14 residues stabilizing the BECN2:ATG14 heterodimer. PMID: 28218432
  3. Both transfected and endogenous beclin 2 coimmunoprecipitated with vGPCR. Beclin 2 overexpression decreased HA-vGPCR steady-state levels. It regulates vGPCR levels by a lysosomal degradation pathway. PMID: 26929373
  4. distinct patterns of Beclin 1 and Beclin 2 were associated with aggressive clinical outcomes. Beclin 1 overexpression, as well as Beclin 2 overexpression and depletion, contributed to tumor growth. PMID: 26506105
  5. Study identified a previously uncharacterized mammalian-specific protein, Beclin 2, which, like Beclin 1, functions in autophagy and interacts with class III PI3K complex components.[Beclin 2] PMID: 23954414

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Subcellular Location Cytoplasm
Protein Families Beclin family
Tissue Specificity Present in fetal and adult brain (at protein level).
Database Links

HGNC: 38606

OMIM: 615687

KEGG: hsa:441925

UniGene: Hs.731347

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