Recombinant Human Beta-defensin 106 (DEFB106A)

Code	CSB-YP836640HU
MSDS	MSDS Datasheet
Size	Pls inquire
Source	Yeast
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Code	CSB-EP836640HU
MSDS	MSDS Datasheet
Size	Pls inquire
Source	E.coli
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Code	CSB-EP836640HU-B
MSDS	MSDS Datasheet
Size	Pls inquire
Source	E.coli
Conjugate	Avi-tag Biotinylated E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code	CSB-BP836640HU
MSDS	MSDS Datasheet
Size	Pls inquire
Source	Baculovirus
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Code	CSB-MP836640HU
MSDS	MSDS Datasheet
Size	Pls inquire
Source	Mammalian cell
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Product Details
Customer Reviews and Q&A
Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

DEFB106A

Uniprot No.

Q8N104

Alternative Names

DEFB106A; BD6; DEFB106; DEFB6;; DEFB106BBeta-defensin 106; Beta-defensin 6; BD-6; DEFB-6; Defensin; beta 106

Species

Homo sapiens (Human)

Expression Region

21-65

Target Protein Sequence

FFDEKCNKLK GTCKNNCGKN EELIALCQKS LKCCRTIQPC GSIID

Protein Length

Cytoplasmic domain

Tag Info

Tag type will be determined during the manufacturing process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Form

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Buffer before Lyophilization

Tris/PBS-based buffer, 6% Trehalose.

Reconstitution

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.

Troubleshooting and FAQs

Protein FAQs

Storage Condition

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Lead Time

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Datasheet

Please contact us to get it.

Customer Reviews and Q&A

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Target Background

Function

Has antibacterial activity. Acts as a ligand for C-C chemokine receptor CCR2.

Gene References into Functions

Unique properties of human beta-defensin 6 (hBD6) and glycosaminoglycan complex: sandwich-like dimerization and competition with the chemokine receptor 2 (CCR2) binding site. PMID: 24970887
DEFB106 (also known as DEFB6) displays antimicrobial activity against E. coli, C. albicans and S. aureus. PMID: 24189797
The epididymis-specific expression pattern of the beta-defensin isoform BD-6 has been characterized. PMID: 12193721
A pilot study with cRNA probes for in situ hybridization and a synthetic propeptide for the functional characterization demonstrated the tissue-/cell-specific expression and the strong antimicrobial activity of DEFB106 PMID: 12600824
Observational study of gene-disease association. (HuGE Navigator) PMID: 19194307

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Subcellular Location

Secreted. Membrane.

Protein Families

Beta-defensin family

Tissue Specificity

Expressed specifically in epididymis and lung.

Database Links

HGNC: 18088

KEGG: hsa:245909

STRING: 9606.ENSP00000335307

UniGene: Hs.511958