Recombinant Human C-type lectin domain family 4 member E (CLEC4E), partial

1. Mincle has the ability to survey mycolate-derived glycolipids from actinomycetes, distinguishing non-pathogenic (e.g. Rhodococcus spp.) and pathogenic (e.g. Mycobacterium tuberculosis) species on the basis of alpha-chain length. PMID: 27714279
2. No association was detected with any of the SNPs analysed and susceptibility to tuberculosis. PMID: 27363694
3. combination adjuvant systems demonstrate markedly different immune activation with age, with combined DC activation via Macrophage-inducible C-type lectin and TLR7/8 representing a novel approach to enhance the efficacy of early-life vaccines. PMID: 27793997
4. We here show that Mincle gene expression was induced in alveolar macrophages and neutrophils in bronchoalveolar lavage fluids of mice and patients with pneumococcal pneumonia PMID: 27923071
5. a nonredundant role for Clec4e in coordinating major biological pathways involved in atherosclerosis PMID: 27587433
6. CLEC4E expression is significantly upregulated in human masticatory mucosa during wound healing PMID: 28005267
7. The expression of Mincle increases significantly during the early period of Aspergillus fumigatus infection, while expression of eight corresponding cytokines changes. Mincle, as a pattern recognition receptor, may play a role in the early innate immune response of the corneal resistance against fungus. PMID: 28141595
8. Induction of Mincle by Helicobacter pylori and consequent anti-inflammatory signaling denote a bacterial survival strategy. PMID: 26456705
9. our findings identify mincle as a contributor to the inflammatory response after traumatic brain injury PMID: 25111533
10. results suggest that cholesterol crystals are an endogenous ligand for hMincle and that they activate innate immune responses PMID: 26296894
11. Data indicate that MINCLE receptor is able to mediate the response to trehalose-6,6-dimycolate (TDM) dependent on SYK kinase and CARD9 protein. PMID: 26202982
12. mincle is a fungal receptor that can suppress antifungal immunity and, as such, is a potential therapeutic target. PMID: 24721577
13. These results demonstrated that GroMM is a unique ligand for human Mincle that is not recognized by mouse Mincle. PMID: 24733387
14. Results show the molecular mechanism of glycolipid recognition through C-type lectin receptors, which may provide clues to rational design for effective adjuvants. PMID: 24101491
15. Macrophage-inducible C-type lectin is associated with anti-cyclic citrullinated peptide antibodies-positive rheumatoid arthritis in men. PMID: 22932191
16. Mincle is a potentially critical player in human B cell responses. PMID: 22698596
17. Data indicate an unusual pattern of reciprocal expression of Mincle on peripheral blood monocytes or neutrophils. PMID: 22641025
18. silencing of renal DNaseI gene expression initiates a cascade of inflammatory signals including activation of Toll like receptors and Clec4e, leading to progression of both murine and human lupus nephritis PMID: 22479529
19. Our data suggest that Mincle is induced in adipose tissue macrophages in obesity at least partly through the saturated fatty acid/TLR4/NF-kappaB pathway, thereby suggesting its pathophysiologic role in obesity-induced adipose tissue inflammation. PMID: 21282371
20. progenitor-derived mast cells expressed the macrophage-inducible C-type lectin receptor Mincle, and exposure of these cells to M. sympodialis induced up-regulation of the mRNA expression of Mincle PMID: 20608913
21. Several functional states mediating the interaction of Mincle and yeast at the surface of the macrophage. PMID: 18509109
22. important for the initiation of an innate immune response to Candida albicans PMID: 19120481

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HGNC: 14555

OMIM: 609962

KEGG: hsa:26253

STRING: 9606.ENSP00000299663

UniGene: Hs.236516