Recombinant Human C2 calcium-dependent domain-containing protein 4A (C2CD4A)

Code CSB-YP818765HU
MSDS
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Source Yeast
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Code CSB-EP818765HU
MSDS
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Source E.coli
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Code CSB-EP818765HU-B
MSDS
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP818765HU
MSDS
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Source Baculovirus
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Code CSB-MP818765HU
MSDS
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Source Mammalian cell
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Product Details

Purity
>85% (SDS-PAGE)
Target Names
C2CD4A
Uniprot No.
Alternative Names
C2CD4A; FAM148A; NLF1C2 calcium-dependent domain-containing protein 4A; Nuclear-localized factor 1; Protein FAM148A
Species
Homo sapiens (Human)
Expression Region
1-369
Target Protein Sequence
MWCLERLRLG PECLRRSGDW LLPGRARGAK SRTTAACANV LTPDRIPEFC IPPRLMPRLA LAALRNSWVE EAGMDEGAGR TDWDPRSQAA LSLPHLPRVR TAYGFCALLE SPHTRRKESL LLGGPPAPRP RAHTYGGGGG PDALLGTLRV PRAPGPATPA APGCPRPPQD ALARRPRGCR LLRVPDGLLS RALRAGRSRR LTRVRSVSSG NEDKERRAGS QSPARAPSTS PPSSRVPFPE RLEAEGTVAL GRAGDALRLA AEYCPGTGRL RLRLLRAESP AGGAPGPRAV SCRLSLVLRP PGTALRQCST VVGRSRKASF DQDFCFDGLS EDEVRRLAVR VKARDEGRGR ERGRLLGQGE LSLGALLLL
Protein Length
full length protein
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

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Target Background

Function
May be involved in inflammatory process. May regulate cell architecture and adhesion.
Gene References into Functions
  1. rs7163757 contributes to genetic risk of islet dysfunction and type 2 diabetes by increasing NFAT-mediated islet enhancer activity and modulating C2CD4B, and possibly C2CD4A, expression in (patho)physiologic states. PMID: 29625024
  2. C2CD4A expression is significantly upregulated in human masticatory mucosa during wound healing PMID: 28005267
  3. An endoplasmic reticulum protein, NLF-1, delivers a sodium leak channel critical for rhythmic locomotion. PMID: 23522043
  4. Single nucleotide polymorphism in C2CD4A is associated with type 2 diabetes. PMID: 20818381
  5. NLF1 may play a role in regulating genes which control cellular architecture. PMID: 15527968

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Subcellular Location
Nucleus.
Protein Families
C2CD4 family
Tissue Specificity
Specifically expressed in endothelial cells.
Database Links

HGNC: 33627

OMIM: 610343

KEGG: hsa:145741

STRING: 9606.ENSP00000347712

UniGene: Hs.202656

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