Recombinant Human CXADR-like membrane protein (CLMP), partial

Product Details

Purity

≥85% (SDS-PAGE)

Target Names

CLMP

Uniprot No.

Alternative Names

CLMP; ACAM; ASAM; UNQ318/PRO363CXADR-like membrane protein; Adipocyte adhesion molecule; Coxsackie- and adenovirus receptor-like membrane protein; CAR-like membrane protein

Species

Homo sapiens (Human)

Protein Length

Partial

Tag Info

Tag type will be determined during the manufacturing process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Form

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Buffer before Lyophilization

Tris/PBS-based buffer, 6% Trehalose.

Reconstitution

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.

Troubleshooting and FAQs

Protein FAQs

Storage Condition

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Lead Time

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Datasheet

Please contact us to get it.

Target Background

Function

May be involved in the cell-cell adhesion. May play a role in adipocyte differentiation and development of obesity. Is required for normal small intestine development.

Gene References into Functions

We describe a newborn presenting CSBS intestinal malrotation and chronic intestinal pseudo-obstruction syndrome (CIPS), compound heterozygous for two previously unreported heterozygous mutations in Coxsackie and adenovirus receptor-like membrane protein (CLMP) gene. We identified two heterozygous mutations in CLMP, one in intron 1 (c.28+1G>C) from the father, the other on exon 4 (c502C>T, p.R168X) from the mother. PMID: 27720179
Inhibition of CFTR or histone deacetylase (HDAC) enhanced CAR expression while CFTR overexpression or restoration of the diminished HDAC activity in cystic fibrosis cells reduced CAR expression. PMID: 27527752
Novel inherited variants in CLMP were identified in three congenital short bowel syndrome patients derived from two unrelated families. PMID: 27352967
The key processes involved in intestinal epithelial development appear to be unaffected by wild type-CLMP or mutant-CLMP. PMID: 23460781
Coxsackievirus and adenovirus receptor gene expression is induced in esophageal cancer cells by the HDAC inhibitor trichostatin A. PMID: 22992863
The PDZ1 and PDZ3 domains of MAGI-1 regulate the eight-exon isoform of the CXADR-like membrane protein. PMID: 22718816
Loss-of-function mutations in CLMP cause congenital short bowel syndrome in human beings, likely by interfering with tight-junction formation, which disrupts intestinal development. PMID: 22155368
CLMP is a novel cell-cell adhesion molecule and a new component of epithelial tight junctions. PMID: 14573622
We identified ACAM (adipocyte adhesion molecule), a novel homologue of the CTX (cortical thymocyte marker in Xenopus) gene family, which may be the critical adhesion molecule in adipocyte differentiation and development of obesity. PMID: 15563274
ASAM, IGSF11, CXADR and ESAM are type I transmembrane proteins and members of the same IGSF superfamily. PMID: 12851705

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Involvement in disease

Congenital short bowel syndrome (CSBS)

Subcellular Location

Cell junction, tight junction. Cell membrane; Single-pass type I membrane protein.

Tissue Specificity

Predominantly expressed in epithelial cells within different tissues and in the white adipose tissue. Expressed at high levels in small intestine and placenta, at intermediate levels in the heart, skeletal muscle, colon, spleen, kidney and lung and at low

Database Links

HGNC: 24039

OMIM: 611693

KEGG: hsa:79827

STRING: 9606.ENSP00000405577

UniGene: Hs.591949

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Recombinant Human CXADR-like membrane protein (CLMP), partial

Product Details

Customer Reviews and Q&A

Target Background

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