Recombinant Human Carbonic anhydrase 12(CA12),partial

Code CSB-EP004367HU
Product Type Recombinant Protein
Size US$1726
Uniprot No. O43570
Relevance Reversible hydration of carbon dioxide.
Image
  • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Storage Buffer Tris-based buffer,50% glycerol
Alias Carbonate dehydratase XII;Carbonic anhydrase XII ;CA-XIITumor antigen HOM-R;CC-3.1.3
Species Homo sapiens (Human)
Purity Greater than 90% as determined by SDS-PAGE.
Sequence APVNGSKWTYFGPDGENSWSKKYPSCGGLLQSPIDLHSDILQYDASLTPLEFQGYNLSANKQFLLTNNGHSVKLNLPSDMHIQGLQSRYSATQLHLHWGNPNDPHGSEHTVSGQHFAAELHIVHYNSDLYPDASTASNKSEGLAVLAVLIEMGSFNPSYDKIFSHLQHVKYKGQEAFVPGFNIEELLPERTAEYYRYRGSLTTPPCNPTVLWTVFRNPVQISQEQLLALETALYCTHMDDPSPREMINNFRQVQKFDERLVYTSFSQVQVCTAAGLS
Research Area Cancer
Source E.coli
Gene Names CA12
Expression Region 25-301aa
Tag Info N-terminal 6xHis-SUMO-tagged
Mol. Weight 47.1kDa
Protein Description Partial
Storage The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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Function Reversible hydration of carbon dioxide.
Involvement in disease Hyperchlorhidrosis, isolated (HCHLH)
Subcellular Location Membrane, Single-pass type I membrane protein
Protein Families Alpha-carbonic anhydrase family
Tissue Specificity Highly expressed in colon, kidney, prostate, intestine and activated lymphocytes. Expressed at much higher levels in the renal cell cancers than in surrounding normal kidney tissue. Moderately expressed in pancreas, ovary and testis.
Database Links

HGNC: 1371

OMIM: 143860

KEGG: hsa:771

STRING: 9606.ENSP00000178638

UniGene: Hs.210995

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