CA12 Antibody

1. Our findings indicate that loss of CA XII function should be considered in individuals without CFTR mutations who exhibit CF-like features in the sweat gland and lung. PMID: 26911677
2. The expression of HIF-1alpha, but not HIF-2alpha, decreased in degenerated disc samples and was positively correlated with carbonic anhydrase 12 expression. PMID: 26901836
3. mutation CA12(E143K) causes mouth dryness disease due to aberrant CA12 glycosylation. PMID: 26486891
4. Suggest CAXII as a new secondary marker of the multidrug resistance phenotype that influences Pgp activity directly. PMID: 25686827
5. an upregulation of CAXII in human T-cell acute lymphoblastic leukemia samples supporting the case that CAXII may represent a new therapeutic target for T-ALL/LL. PMID: 23348702
6. Serum CAXII levels were significantly higher in lung cancer patients than in healthy controls, providing evidence that CAXII may be a novel sero-diagnostic marker for lung cancer. PMID: 22439015
7. The expression of CA XII in oral squamous cell carcinoma (OSCC) samples can predict the progression of OSCC and survival of OSCC patients. PMID: 22172588
8. The development of acidosis with topiramate and zonisamide is not determined by drug dose or by treatment duration, but may be influenced by polymorphisms in the gene for CA type XII. PMID: 21278619
9. Data show that genes overexpressed in breast carcinoma including TFF1, TFF3, FOXA1 and CA12.Data show that genes overexpressed in breast carcinoma including TFF1, TFF3, FOXA1 and CA12. PMID: 20132413
10. Study identified the association of a Glu143Lys mutation in carbonic anhydrase 12 (CA12) with the disease. PMID: 21184099
11. we demonstrate that the hyperchlohidrosis phenotype is due to a homozygous mutation in CA12, encoding carbonic anhydrase XII. PMID: 21035102
12. CA12 may be used as a novel prognostic marker in combination with histologic grade of invasive cervical cancer. PMID: 21040567
13. Carbonic anhydrase XII may affect the capability of invasion and migration of MDA-MB-231 cells, which may be mediated through the p38 MAPK pathway. PMID: 20434230
14. Suggest that CA XII should be considered a potential prognostic and therapeutic target in medulloblastomas and supratentorial primitive neuroectodermal tumours. PMID: 20398423
15. Differential modulation of the active site environment of human carbonic anhydrase XII by cationic quantum dots and polylysine. PMID: 20215053
16. The non-pigmented ciliary epithelial cells from glaucoma eyes expressed higher levels of CAXII, which may be a targeted gene in glaucoma. PMID: 12676895
17. CA XII showed no or weak immunoreaction in the normal gastric mucosa and was slightly increased in gastric tumors. PMID: 12854129
18. The interplay between the functional von Hippel-Lindau tumor suppressor and CA IX/CA XII in colorectal tumors seems rather PMID: 15849821
19. CA12 mRNA expression was detected in 88.1% of cervical cancers. PMID: 16416108
20. CA XII is commonly expressed in diffuse astrocytomas and that it might be used as a biomarker of poor prognosis. PMID: 18322268
21. Carbonic anhydrase (CA) IX (and possibly also CA XII) participates in pH regulation, which is important for survival of hypoxic cancer cells. Both enzymes are therefore promising targetable therapeutic molecules. [Review] PMID: 18336315
22. Crucial role of ER in the regulation of the CA12 gene. PMID: 18451179
23. In embryonic and early fetal tissues; there is no evidence of co-localization of CAIX and CAXII; CAIX and CAXII expression is closely related to cell origin and secretory activity involving proton transport, respectively. PMID: 19291313

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HGNC: 1371

OMIM: 143860

KEGG: hsa:771

STRING: 9606.ENSP00000178638

UniGene: Hs.210995