CA12 Antibody

Code CSB-PA004367YA01HU
Size US$166
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  • Western blot
    All lanes: CA12 antibody at 6µg/ml + Mouse kidney tissue
    Secondary
    Goat polyclonal to rabbit IgG at 1/10000 dilution
    Predicted band size: 40, 39 kDa
    Observed band size: 40, 48 kDa

  • Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA004367YA01HU at dilution of 1:100

  • Immunohistochemistry of paraffin-embedded human pancreatic tissue using CSB-PA004367YA01HU at dilution of 1:100

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) CA12 Polyclonal antibody
Uniprot No.
Target Names
CA12
Alternative Names
CA 12 antibody; CA XII antibody; CA-XII antibody; CA12 antibody; CAH12_HUMAN antibody; Carbonate dehydratase XII antibody; Carbonic anhydrase 12 antibody; Carbonic anhydrase XII antibody; Carbonic dehydratase antibody; CAXII antibody; FLJ20151 antibody; HsT18816 antibody; T18816 antibody; Tumor antigen HOM RCC 3.1.3 antibody; Tumor antigen HOM-RCC-3.1.3 antibody
Raised in
Rabbit
Species Reactivity
Human, Mouse
Immunogen
Recombinant Human Carbonic anhydrase 12 protein (25-301AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The CA12 Antibody (Product code: CSB-PA004367YA01HU) is Non-conjugated. For CA12 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA004367YB01HU CA12 Antibody, HRP conjugated ELISA
FITC CSB-PA004367YC01HU CA12 Antibody, FITC conjugated
Biotin CSB-PA004367YD01HU CA12 Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA, WB, IHC
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:2000
IHC 1:20-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Reversible hydration of carbon dioxide.
Gene References into Functions
  1. Our findings indicate that loss of CA XII function should be considered in individuals without CFTR mutations who exhibit CF-like features in the sweat gland and lung. PMID: 26911677
  2. The expression of HIF-1alpha, but not HIF-2alpha, decreased in degenerated disc samples and was positively correlated with carbonic anhydrase 12 expression. PMID: 26901836
  3. mutation CA12(E143K) causes mouth dryness disease due to aberrant CA12 glycosylation. PMID: 26486891
  4. Suggest CAXII as a new secondary marker of the multidrug resistance phenotype that influences Pgp activity directly. PMID: 25686827
  5. an upregulation of CAXII in human T-cell acute lymphoblastic leukemia samples supporting the case that CAXII may represent a new therapeutic target for T-ALL/LL. PMID: 23348702
  6. Serum CAXII levels were significantly higher in lung cancer patients than in healthy controls, providing evidence that CAXII may be a novel sero-diagnostic marker for lung cancer. PMID: 22439015
  7. The expression of CA XII in oral squamous cell carcinoma (OSCC) samples can predict the progression of OSCC and survival of OSCC patients. PMID: 22172588
  8. The development of acidosis with topiramate and zonisamide is not determined by drug dose or by treatment duration, but may be influenced by polymorphisms in the gene for CA type XII. PMID: 21278619
  9. Data show that genes overexpressed in breast carcinoma including TFF1, TFF3, FOXA1 and CA12.Data show that genes overexpressed in breast carcinoma including TFF1, TFF3, FOXA1 and CA12. PMID: 20132413
  10. Study identified the association of a Glu143Lys mutation in carbonic anhydrase 12 (CA12) with the disease. PMID: 21184099
  11. we demonstrate that the hyperchlohidrosis phenotype is due to a homozygous mutation in CA12, encoding carbonic anhydrase XII. PMID: 21035102
  12. CA12 may be used as a novel prognostic marker in combination with histologic grade of invasive cervical cancer. PMID: 21040567
  13. Carbonic anhydrase XII may affect the capability of invasion and migration of MDA-MB-231 cells, which may be mediated through the p38 MAPK pathway. PMID: 20434230
  14. Suggest that CA XII should be considered a potential prognostic and therapeutic target in medulloblastomas and supratentorial primitive neuroectodermal tumours. PMID: 20398423
  15. Differential modulation of the active site environment of human carbonic anhydrase XII by cationic quantum dots and polylysine. PMID: 20215053
  16. The non-pigmented ciliary epithelial cells from glaucoma eyes expressed higher levels of CAXII, which may be a targeted gene in glaucoma. PMID: 12676895
  17. CA XII showed no or weak immunoreaction in the normal gastric mucosa and was slightly increased in gastric tumors. PMID: 12854129
  18. The interplay between the functional von Hippel-Lindau tumor suppressor and CA IX/CA XII in colorectal tumors seems rather PMID: 15849821
  19. CA12 mRNA expression was detected in 88.1% of cervical cancers. PMID: 16416108
  20. CA XII is commonly expressed in diffuse astrocytomas and that it might be used as a biomarker of poor prognosis. PMID: 18322268
  21. Carbonic anhydrase (CA) IX (and possibly also CA XII) participates in pH regulation, which is important for survival of hypoxic cancer cells. Both enzymes are therefore promising targetable therapeutic molecules. [Review] PMID: 18336315
  22. Crucial role of ER in the regulation of the CA12 gene. PMID: 18451179
  23. In embryonic and early fetal tissues; there is no evidence of co-localization of CAIX and CAXII; CAIX and CAXII expression is closely related to cell origin and secretory activity involving proton transport, respectively. PMID: 19291313

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Involvement in disease
Hyperchlorhidrosis, isolated (HCHLH)
Subcellular Location
Membrane; Single-pass type I membrane protein. Cell membrane.
Protein Families
Alpha-carbonic anhydrase family
Tissue Specificity
Highly expressed in colon, kidney, prostate, intestine and activated lymphocytes. Expressed at much higher levels in the renal cell cancers than in surrounding normal kidney tissue. Moderately expressed in pancreas, ovary and testis. Expressed in sweat gl
Database Links

HGNC: 1371

OMIM: 143860

KEGG: hsa:771

STRING: 9606.ENSP00000178638

UniGene: Hs.210995

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