Recombinant Human Cbp/p300-interacting transactivator 2 (CITED2)

1. Knockdown of CITED2 led to a decreased interaction of p53 with its inhibitor MDM2, which results in increased amounts of total p53 protein. Data indicate that CITED2 functions in pathways regulating p53 activity. PMID: 29072699
2. CITED2 regulates primary breast tumor growth, likely by influencing tumor vasculature via TGF-beta-dependent regulation of VEGFA. PMID: 28008154
3. The results suggest that CITED2 mutations in conserved regions lead to disease-causing biological and functional changes and may contribute to the occurrence of conotruncal heart defects in Chinese children. PMID: 28436679
4. CITED2 gene mutation may play a significant role in the development of pediatric congenital heart disease. PMID: 28687891
5. CITED2 supports gastric cancer cell colony formation and proliferation while inhibiting apoptosis making it a potential gene therapy target for gastric cancer. PMID: 28501104
6. Through allosteric enhancement of HIF-1alpha release, CITED2 activates a highly responsive negative feedback circuit that rapidly and efficiently attenuates the hypoxic response, even at modest CITED2 concentrations. PMID: 28273070
7. down-regulation of Cited2 was associated with high glucose-induced apoptosis in cardiomyocytes in vitro PMID: 27680315
8. High Cited2 level in cumulus cells was associated with low embryo quality and pregnancy outcome in in vitro fertilization patients. PMID: 26812245
9. the downregulation of CITED2 contributes to TGFbeta-mediated senescence. PMID: 28084522
10. CITED2 plays important roles in the progression and chemoresistance of breast carcinoma and that CITED2 status is a potent prognostic factor in breast cancer patients. PMID: 27627783
11. Intrinsic protein disorder plays a prominent role in the function and interactions of the transcriptional co-activators CBP and p300. (Review) PMID: 26851278
12. FBXL5-mediated degradation of CITED2 leads to the activation of HIF-1 alpha. PMID: 25956243
13. The increased CITED2 expression in acute myeloid leukemia results in better hematopoietic stem cell survival, lower PU.1 levels, and perturbed myeloid differentiation program that contributes to leukemia persistence. PMID: 25184385
14. CITED2 has a potential causative impact on congenital heart disease PMID: 24848765
15. Our study suggests that CITED2 gene mutations and methylation may play an important role in the development of pediatric congenital heart disease. PMID: 24456003
16. data indicate that CITED2 functions as a transcriptional co-activator of ER in breast cancer cells and that its increased expression in tumors may result in estrogen-independent ER activation PMID: 23811274
17. CITED2 is a direct effector of PPARgamma for tumor suppression. PMID: 23212831
18. CITED2 functions as a molecular switch of TGF-alpha and TGF-beta-induced growth control, and MYC-CITED2 signaling axis provides a new index for predicting clinical outcome. PMID: 22814619
19. CITED2 is phosphorylated by MAPK1 in vitro at T166, and that MAPK1 activation enhances the coactivation function of CITED2 but not of CITED2-T166N. PMID: 23082118
20. We conclude that mutations in CITED2 may be involved in premature ovarian failure pathogenesis. PMID: 22709740
21. CITED2 variants decreased its ability to mediate the expression of vascular endothelial growth factor (VEGF) and the expression of the paired-like homeodomain transcription factor 2-gamma (PITX2C), both of which are closely related to cardiac development. PMID: 22735262
22. A combination of cisplatin and CITED2 shRNA may represent an effective treatment against p53-sensitive cancer cells. PMID: 21660965
23. CITED2 activation may induce mucosal apoptosis and erosion by activating p53 and thus play a critical role in linking enteric bacteria with mucosal inflammation in ulcerative colitis. PMID: 21165656
24. CITED2 is a novel regulator of NF-kappaB in the nucleus, which reveals a negative feedback mechanism for NF-kappaB signaling. PMID: 21098220
25. CITED2 may act as a mechanosensitive molecular switch regulating cartilage matrix breakdown. PMID: 20392269
26. Reducing CITED2 expression in a mammary tumor cell line inhibits the establishment of bone metastasis and osteolysis in vivo. PMID: 19642106
27. Both TGFbeta and flow shear stimulated expression of CITED2 and also association of CIT-ED2 with p300 by dissociating Ets-1 from p300. Thus, CITED2 plays a major role in shear-induced down-regulation of MMP-1 and MMP-13 via a TGFbeta-dependent pathway. PMID: 12960175
28. CIT-ED2 is a coactivator of PPARalpha and both proteins may participate in signaling cascades of hypoxic response and angiogenesis PMID: 15051727
29. CITED2 mutations have a causative impact in the development of CHD in humans. PMID: 16287139
30. TGF-beta-mediated down-regulation of Cited2 is post-transcriptional, through the Smad pathway, and requires the presence of its coding sequence PMID: 16675452
31. Cited2, a coactivator of HNF4alpha, is essential for liver development PMID: 17932483
32. CITED2 regulates colon cancer invasion and might be a target for histone deacetylase inhibitor-based intervention of colon cancer. PMID: 18054336
33. CITED2 and PBX1 are likely to be important mediators of adrenal development and function in humans, but mutations in these genes are not common causes of adrenal failure. PMID: 18984668
34. The effects of endothelial-cell-conditioned medium (ECCM), as produced during the incubation of human umbilical vein endothelial cells for 24 h, on the promoter activity and mRNA and protein expression of CITED2 in adrenocortical cells, was examined. PMID: 19319572
35. Both NCOR2 and CITED2 mRNA levels were associated with MFS, that is, tumour aggressiveness, independently of traditional prognostic factors PMID: 19904269

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HGNC: 1987

OMIM: 602937

KEGG: hsa:10370

STRING: 9606.ENSP00000356623

UniGene: Hs.82071