Recombinant Human Choline kinase alpha (CHKA)

1. miR-876-5p was able to significantly decrease the expression level of choline kinase alpha mRNA. PMID: 29568919
2. There is no correlation between single CHKA rs7928739 polymorphism and the incidence of intrauterine fetal death. PMID: 28509322
3. This study presents the detail the 2.35 A structure of choline kinase alpha in complex with inhibitor TCD-717. PMID: 29389115
4. Results indicate that choline kinase alpha (CHKA) contributes to tumor progression and metastasis and may serve as a prognostic biomarker and potential therapeutic target in colorectal carcinoma (CRC). PMID: 27556502
5. hCKalpha functions as an indispensable regulator that bridges PI4KIIIalpha and hepatitis C virus NS5A and potentiates NS5A-stimulated PI4KIIIalpha activity, which then facilitates the targeting of the ternary complex to the endoplasmic reticulum for viral replication. PMID: 28566381
6. We found levels of CHKA to be increased in human HCCs compared to nontumor tissues, and increased expression to be associated with tumor aggressiveness. Overexpression of CHKA in HCC cell lines increased their invasiveness, resistance to EGFR inhibitors, and ability to form metastatic tumors in mice by promoting interaction of EGFR with mechanistic target of rapamycin complex 2. PMID: 28065789
7. These findings demonstrate that hCKalpha forms a complex with hepatitis C virus NS5A and that hCKalpha activity enhances the targeting of the complex to the endoplasmic reticulum, where hCKalpha protein, not activity, mediates NS5A binding to NS5B, thereby promoting functional membranous viral replication complex assembly and viral RNA replication. PMID: 27489281
8. Study shows increased CHKA expression in pancreatic ductal adenocarcinoma tumors and may be a predictive marker of response to chemotherapy. PMID: 26769123
9. These data also support the approach of antitumor strategies that destabilize Chk-alpha protein or downregulate PtdCho in breast cancer treatment. PMID: 26503172
10. Downregulation of choline kinase-alpha enhances autophagy in tamoxifen-resistant breast cancer cells. PMID: 26496360
11. CHKA can act as an AR chaperone, providing, to our knowledge, the first evidence for kinases as molecular chaperones, making CHKA both a marker of tumor progression and a potential therapeutic target for PCa. PMID: 26657335
12. Identify choline kinase alpha as a key regulator of glutathione-dependent antioxidant cell defense in ovarian carcinoma. PMID: 25796169
13. choline kinase alpha is inhibited by a near-infrared fluorescent carbocyanine PMID: 25028471
14. Increased expression of CHKA is seen in malignant lesions of prostate cancer PMID: 26041862
15. Chokalpha possessed oncogenic activity and could be a potential therapeutic target in T-cell lymphoma , as well as other hematological malignancies with interrupted Ras signaling pathways PMID: 25768400
16. Downregulation of Chk-alpha with siRNA increased PLD1 expression, and downregulation of PLD1 increased Chk-alpha expression. PMID: 24556997
17. there is a role for the ChoKalpha protein in promoting cancer cell survival that is independent of its catalytic activity. PMID: 25522435
18. The significance of CHKA overexpression on a TMA. PMID: 25267063
19. Our data suggest that choline kinase and its product phosphocholine are required for the normal growth and mineralization of MG-63 cells. PMID: 24583375
20. pharmacological inhibition of ChoKalpha induces cancer cell death through a mechanism that involves the activation of exaggerated and persistent ER stress supported by CHOP overproduction. PMID: 24287694
21. Chk-alpha expression and the effect of its downregulation in human umbilical vein endothelial cells, is reported. PMID: 23775813
22. In EOC that CHKA downregulation significantly decreased the aggressive EOC cell. PMID: 24281000
23. CHKA SNPs (rs3794186 and rs11481) are not associated with HCC development; however, rs3794186 may correlate with serum AFP levels in HCC. PMID: 22972156
24. High choline kinase A expression is associated with colorectal cancer. PMID: 23762272
25. A combination of initial velocity and product inhibition studies, together with the kinetic and structural characterisation of a novel ChoKalpha inhibitor is used to support a mechanism of action for human ChoKalpha. PMID: 23416529
26. HK2 and CKA expression may have biologic and prognostic significance in hepatocellular carcinoma, with tumor HK2 expression being a potential independent predictor of survival. PMID: 23071593
27. ASAH1 inhibition synergistically sensitizes lung cancer cells resistant to the antiproliferative effect of choline kinase alpha inhibitors. PMID: 22515519
28. Data show choline kinase alpha (CHKalpha) expressed in both cytoplasm and nucleus in malignant lesions. PMID: 22038995
29. these results strongly implicate a new c-Src-dependent link between CHKA and EGFR, which contributes to the regulation of cell proliferation and tumorigenesis. PMID: 21822308
30. kinetic studies revealed that HC-3 is a much more potent inhibitor for ChoKalpha isoforms (alpha1 and alpha2) compared with ChoKbeta. PMID: 20299452
31. From our data, we proposed that Choline kinase plays a key role in regulating Akt(ser473) phosphorylation, thereby promoting cell survival and proliferation PMID: 20042122
32. ChoKalpha and ChoKbeta isoforms have different physiological roles and implications in human carcinogenesis PMID: 19915674
33. Data show that RNA silencing of choline kinase in HeLa cells completely abrogates the high concentration of phosphocholine, which in turn decreases phosphatidylcholine, phosphatidic acid and signaling through the MAPK and PI3K/AKT pathways. PMID: 19855431
34. activity regulated by Ras proteins through Ral-GDS and PI-3-kinase; has role in malignant transformation PMID: 11840339
35. ChoK overexpression was found in 17% of the samples. ChoK may be related to the development of human breast cancer, suggesting that this finding may suggest a novel antitumoral strategy. PMID: 12082619
36. upregulation of choline kinase is a frequent feature in human tumor-derived cell lines and in lung, prostate, and colorectal cancers PMID: 12176020
37. ChoK may have a role in carcinogenesis PMID: 16820874
38. Analyses showed genotype effects of CHKA genes on spina bifida risk, but did not show evidence of gene-nutrient. PMID: 17184542
39. These data suggest that HIF-1 activation of HREs within the putative chk-a promoter region can increase Chk-A expression within hypoxic environments, consequently increasing cellular PC and tCho levels within these environments. PMID: 18172309
40. The molecular basis to understand the connection between phospholipids metabolism and cell cycle regulation through choline kinase is reported. PMID: 18296102
41. The rates of choline kinase reaction in cell lysates of MDA-MB-231 breast, PC-3 prostate and HeLa cervical cancer cells and in solutions of purified human ChoK, was measured. PMID: 19156696
42. ChoKalpha plays a role in the aggressiveness of bladder tumors and constitutes a new approach for bladder cancer treatment. PMID: 19448670

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HGNC: 1937

OMIM: 118491

KEGG: hsa:1119

STRING: 9606.ENSP00000265689

UniGene: Hs.77221