Recombinant Human Chondroadherin-like protein (CHADL)

Code CSB-YP764668HU
MSDS
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Source Yeast
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Code CSB-EP764668HU
MSDS
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Source E.coli
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Code CSB-EP764668HU-B
MSDS
Size Pls inquire
Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP764668HU
MSDS
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Source Baculovirus
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Code CSB-MP764668HU
MSDS
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Source Mammalian cell
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Product Details

Purity
≥85% (SDS-PAGE)
Target Names
CHADL
Uniprot No.
Alternative Names
CHADL; SLRR4BChondroadherin-like protein
Species
Homo sapiens (Human)
Expression Region
31-762
Target Protein Sequence
QRCPQACICD NSRRHVACRY QNLTEVPDAI PELTQRLDLQ GNLLKVIPAA AFQGVPHLTH LDLRHCEVEL VAEGAFRGLG RLLLLNLASN HLRELPQEAL DGLGSLRRLE LEGNALEELR PGTFGALGAL ATLNLAHNAL VYLPAMAFQG LLRVRWLRLS HNALSVLAPE ALAGLPALRR LSLHHNELQA LPGPVLSQAR GLARLELGHN PLTYAGEEDG LALPGLRELL LDGGALQALG PRAFAHCPRL HTLDLRGNQL DTLPPLQGPG QLRRLRLQGN PLWCGCQARP LLEWLARARV RSDGACQGPR RLRGEALDAL RPWDLRCPGD AAQEEEELEE RAVAGPRAPP RGPPRGPGEE RAVAPCPRAC VCVPESRHSS CEGCGLQAVP RGFPSDTQLL DLRRNHFPSV PRAAFPGLGH LVSLHLQHCG IAELEAGALA GLGRLIYLYL SDNQLAGLSA AALEGAPRLG YLYLERNRFL QVPGAALRAL PSLFSLHLQD NAVDRLAPGD LGRTRALRWV YLSGNRITEV SLGALGPARE LEKLHLDRNQ LREVPTGALE GLPALLELQL SGNPLRALRD GAFQPVGRSL QHLFLNSSGL EQICPGAFSG LGPGLQSLHL QKNQLRALPA LPSLSQLELI DLSSNPFHCD CQLLPLHRWL TGLNLRVGAT CATPPNARGQ RVKAAAAVFE DCPGWAARKA KRTPASRPSA RRTPIKGRQC GADKVGKEKG RL
Protein Length
Full Length of Mature Protein
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose.
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

Customer Reviews and Q&A

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Target Background

Function
Potential negative modulator of chondrocyte differentiation. Inhibits collagen fibrillogenesis in vitro. May influence chondrocyte's differentiation by acting on its cellular collagenous microenvironment.
Gene References into Functions
  1. Data show that a rare missense variant in the COMP gene (cartilage oligomeric matrix protein) and a frameshift variant in the CHADL gene (chondroadherin-like protein) strongly associate with osteoarthritis total hip replacement. PMID: 28319091
  2. CHADL appears to have a negative regulatory role, possibly ensuring the formation of a stable extracellular matrix. PMID: 25451920
Subcellular Location
Secreted. Secreted, extracellular space, extracellular matrix.
Protein Families
Small leucine-rich proteoglycan (SLRP) family, SLRP class IV subfamily
Database Links

HGNC: 25165

OMIM: 616236

KEGG: hsa:150356

STRING: 9606.ENSP00000216241

UniGene: Hs.344488

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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Address
No. 269, Shendun 5th Road, Donghu Hi-Tech Development Area, Hubei Province, 430206, P.R.China
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