Recombinant Human Class E basic helix-loop-helix protein 41 (BHLHE41)

1. We validated DEC2 gene as a direct target of miR-873 which could reverse the repressive effects of miR-873 on esophageal cancer cell. PMID: 29890466
2. Knockdown of DEC2 resulted in a significant (26.7%) reduction of VEGF expression in MIO-M1 cells under hypoxia-mimicking conditions induced by DFO (P < .05). Levels of HIF1alpha protein were also reduced significantly, by 60.2%, in MIO-M1 cells treated with siRNA against the DEC2 gene (P < .05). Moreover, HIF1alpha levels showed a significant (2.5-fold) increase in MIO-M1 cells overexpressing DEC2 (P < .05). PMID: 30250985
3. Mutation in DCE2 gene is associated with short sleep behavioral trait. PMID: 29531056
4. It has been concluded that the renal cell carcinoma risk allele at 12p12.1 maps to rs7132434, a functional variant in an enhancer that upregulates BHLHE41 expression which, in turn, induces IL-11, a member of the IL-6 cytokine family. PMID: 27384883
5. venous levels lower in preeclampsia than in normal pregnancy PMID: 27845885
6. The renal cell cancers associated polymorphic HIF-binding site at chromosome 12p12.1 regulates BHLHE41 expression. PMID: 28715484
7. Findings suggest that basic helix-loop-helix family, member e41 protein (DEC2) suppresses cell cycle progression of the mesenchymal cells. PMID: 27430159
8. DEC1, at least partly, exerted a pro-apoptotic effect, whereas DEC2 exerted an anti-apoptotic effect in paclitaxel-induced apoptosis of human prostate cancer cells. PMID: 27840924
9. the present study indicated that SHARP1 acts as a tumor suppressor in thyroid cancer and that its downregulation may contribute to the proliferation, migration and invasion of thyroid cancer cells through mechanisms possibly involving HIF1alpha PMID: 27121679
10. Study found that DEC2 was a direct target of miR-138. PMID: 27095063
11. DEC2 is aberrantly expressed in rheumatoid arthritis tissue, it is induced by TNFalpha and not only affects the expression of genes belonging to molecular clock but also significantly impacts on the expression of IL-1beta as well as other inflammatory genes. PMID: 26710124
12. BHLHE40/41 are promising markers to predict the aggressiveness of each Endometrial Neoplasm case and that molecular targeting strategies involving BHLHE40/41 and SP1 may effectively regulate Endometrial Neoplasm progression. PMID: 26391953
13. DEC2 facilitates HIF-1alpha stabilization and promotes HIF-1 activation in osteosarcoma. PMID: 25884381
14. DEC2 participates in hypoxia-induced cell proliferation by functioning as a target gene of the PI3K/Akt signaling pathway and regulating the expression of c-Myc. PMID: 25524285
15. SHARP1 interacted with HIF-1alpha physically. PMID: 24918449
16. Data suggest that SHARP1 plays a critical role in tumorigenesis and acquisition of the metastatic phenotype in endometrial cancer. PMID: 24997474
17. DEC2 regulates cellular function by modulating the expression of Twist1 PMID: 25446074
18. BHLHE41 mutations reduce total sleep while maintaining NREM sleep and provide resistance to the effects of sleep loss; mutations that affect sleep also modify the normal inhibition of BHLHE41 of CLOCK/BMAL1 transactivation PMID: 25083013
19. we find high frequency of RAS mutations in t(6;11)(q27;q23) pediatric AML and are the first to report a unique and significant differential overexpression of BHLHB3 in these patients. PMID: 24561520
20. GLI1 expression was immunohistochemically related positively with BHLHE41 and inversely with MLH1 in PDAC cells and precancerous lesions of the pancreas. PMID: 24165159
21. Sumoylation of Sharp-1 exerts an impact on chromatin structure and transcriptional repression of muscle gene expression through recruitment of G9a. PMID: 23637228
22. DEC2 regulates apoptosis in oral cancer cells via regulation of pro-apoptotic factor Bim expression PMID: 22572381
23. SHARP1 is required, and sufficient, to limit expression of HIF-target genes PMID: 22801492
24. results suggest that DEC2 periodically represses the promoter activity of CYP2D6, resulting in its circadian expression in serum-shocked cells PMID: 22355045
25. DEC2 has anti-apoptotic effects on the paclitaxel-induced apoptosis in human breast cancer MCF-7 cells. PMID: 21327324
26. demonstrated DEC2 expression in response to the treatment with polyinosinic-polycytidylic acid (poly IC), an authentic double-stranded RNA, in cultured human mesangial cells PMID: 21129405
27. a corepressor complex containing CtIP/CtBP facilitates RBP-Jkappa/SHARP-mediated repression of Notch target genes PMID: 16287852
28. DEC1 and DEC2 may play a crucial role in the adaptation to hypoxia PMID: 12354771
29. Dec1 and Dec2 are regulators of the mammalian molecular clock, and form a fifth clock-gene family. [dec1] PMID: 12397359
30. DEC1-mediated repression on the expression of DEC2 PMID: 12624110
31. role of the BHLHB3 protein as a tumor suppressor for lung cancer. PMID: 18223678
32. MLH1 is transcriptionally repressed by the hypoxia-inducible transcription factors, DEC1 and DEC2. PMID: 18345027
33. DEC1, along with DEC2, plays a role in the finer regulation and robustness of the molecular clock CLOCK/BMAL1 PMID: 18411297
34. study identified a mutation, P385R, in DEC2 associated with a short sleep phenotype; activity profiles & sleep recordings of transgenic mice carrying this mutation showed increased vigilance time and less sleep time than control mice PMID: 19679812

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HGNC: 16617

OMIM: 606200

KEGG: hsa:79365

STRING: 9606.ENSP00000242728

UniGene: Hs.177841