Recombinant Human Coiled-coil domain-containing protein 80 (CCDC80), partial

Code CSB-YP741736HU
MSDS
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Source Yeast
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Code CSB-EP741736HU
MSDS
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Source E.coli
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Code CSB-EP741736HU-B
MSDS
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP741736HU
MSDS
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Source Baculovirus
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Code CSB-MP741736HU
MSDS
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Source Mammalian cell
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Product Details

Purity
>85% (SDS-PAGE)
Target Names
CCDC80
Uniprot No.
Alternative Names
2610001E17Rik; CCD50; CCD80_HUMAN; CCDC80; CL2; Coiled coil domain containing 80; Coiled coil domain containing protein 50; Coiled-coil domain-containing protein 80; Down regulated by oncogenes protein 1; Down-regulated by oncogenes protein 1; DRO1; MGC131805; MGC134851; Nuclear envelope protein okuribin; okuribin; OTTMUSP00000030743; Protein Ymer; SSG1; steroid sensitive gene 1; steroid sensitive protein 1; Up-regulated in BRS-3 deficient mouse homolog; URB
Species
Homo sapiens (Human)
Protein Length
Partial
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

Customer Reviews and Q&A

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Target Background

Function
Promotes cell adhesion and matrix assembly.
Gene References into Functions
  1. Ccdc80 is a novel betacat-regulated gene in adrenocortical cells PMID: 25029241
  2. activation of PKGI with cGMP regulated SSG1 intracellular distribution. PMID: 23831687
  3. Data suggest that CCDC80 expression is down-regulated in many thyroid carcinomas; loss of heterozygosity partially accounts for CCDC80 down-regulation in thyroid carcinoma; CCDC80 expression positively regulates expression of E-cadherin. PMID: 23666966
  4. The CCDC80 protein has three P-DUDES structural domains. These domains have significant albeit remote sequence similarity to thioredoxin-like domains and are predicted to have an oxidoreductase function. PMID: 209648
  5. Results reveal DRO1 as an AIB1-targeted tumor suppressor, providing a novel mechanism for AIB1-dependent inhibition of apoptosis. PMID: 21871888
  6. Downregulated during osteoblastic differentiation of bone marrow stromal cells. Suggests role in skeletogenesis. PMID: 15325258
  7. URB is expressed in human dermal papilla cells PMID: 15998583
  8. In conclusion, the expression pattern of URB suggests its role in obesity and the results suggest that URB is secreted, at least in part, from adipocytes. PMID: 18178152

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Subcellular Location
Secreted, extracellular space, extracellular matrix.
Protein Families
CCDC80 family
Tissue Specificity
Expressed in dermal papilla and dermal fibroblasts (at protein level). Expressed in heart, thymus, placenta, pancreas, colon, epithelium, spleen and osteoblasts.
Database Links

HGNC: 30649

OMIM: 608298

KEGG: hsa:151887

STRING: 9606.ENSP00000206423

UniGene: Hs.477128

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