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Recombinant Human Collagen alpha-1 (XV) chain (COL15A1), partial

Recombinant Human Collagen alpha-1 (XV) chain (COL15A1), partial

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Code	CSB-EP005722HU
Abbreviation	Recombinant Human COL15A1 protein, partial
MSDS	MSDS Datasheet
Size	$306
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Image	(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
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Product Details
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Target Background

Product Details

Purity

Greater than 90% as determined by SDS-PAGE.

Target Names

COL15A1

Uniprot No.

P39059

Research Area

Cancer

Species

Homo sapiens (Human)

Source

E.coli

Expression Region

40-228aa

Target Protein Sequence

HLDLTQLIGVPLPSSVSFVTGYGGFPAYSFGPGANVGRPARTLIPSTFFRDFAISVVVKPSSTRGGVLFAITDAFQKVIYLGLRLSGVEDGHQRIILYYTEPGSHVSQEAAAFSVPVMTHRWNRFAMIVQGEEVTLLVNCEEHSRIPFQRSSQALAFESSAGIFMGNAGATGLERFTGSLQQLTVHPDP
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Mol. Weight

26.5 kDa

Protein Length

Partial

Tag Info

N-terminal 10xHis-tagged

Form

Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Buffer

If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.

Reconstitution

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Our default final concentration of glycerol is 50%. Customers could use it as reference.

Troubleshooting and FAQs

Protein FAQs

Storage Condition

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Lead Time

3-7 business days

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Datasheet & COA

Please contact us to get it.

Description

Recombinant Human COL15A1 protein is an ideal choice for researchers investigating the role of collagen in cancer biology. The collagen alpha-1(XV) chain, encoded by the COL15A1 gene, is an essential component of basement membranes, where it participates in the regulation of cellular functions, including cell adhesion, migration, and proliferation.

This recombinant protein features a partial sequence of the human COL15A1 (40-228aa) and is produced in E.coli, ensuring a high-quality and reliable protein for your research needs. The N-terminal 10xHis tag facilitates easy purification and detection in various applications. With a purity greater than 90% as determined by SDS-PAGE, our Recombinant Human COL15A1 protein offers a consistent and reliable tool for cancer research. The lyophilized powder format provides convenience and stability, enabling easy reconstitution and immediate use in your experiments.

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Target Background

Function

Structural protein that stabilizes microvessels and muscle cells, both in heart and in skeletal muscle.; Restin potently inhibits angiogenesis.

Gene References into Functions

COL15A1 mRNA was up-regulated in hepatocellular cancer (HCC) and collagen XV was expressed along the sinusoid-like endothelium of HCC but not in non-tumoral regions, which implies that collagen XV contributes to the capillarization of HCC. PMID: 26293333
This study demonstrated that novel role for collagen XV in motor axon pathfinding and neuromuscular development. PMID: 26937007
we identified an epithelial ovarian cancer susceptibility loci at 9q22.33 (rs1413299 in COL15A1, P(meta) = 1.88 x 10(-8)) PMID: 25134534
The obtained results indicate that the changes in gene expression in bone marrow progenitor cells can be involved into space flight-induced osteopenia. PMID: 25509878
COL15A1, provide evidence for concomitant epigenetic regulation and genetic susceptibility, and define a class of causal targets that sit at the intersection of genetic and epigenetic predisposition in the etiology of complex disease. PMID: 23912340
These results suggest genetic variation in COL15A1 and COL18A1 can modify the age of onset of both early and late onset POAG. PMID: 23621901
Collagen type XV and osteocalcin expression are highly sensitive markers to extracellular calcium PMID: 22034088
the crystal structure of the trimerization domain of human type XV collagen PMID: 20932905
type XV and XVIII collagens are expressed in specialized basement membranes. PMID: 11937714
Results show that the molecular structure of human tissue type XV presents a unique conformation among the collagens. PMID: 17355226
the primary determinant is the gene specifying collagen XV, a proteoglycan closely associated with the basement membrane PMID: 18171981
Polymorphisms in COL15 (collagen XV) gene are not associated with systemic sclerosis PMID: 18203317
Data represent the first evidence of the expression of collagen type XV in human osteoblasts, a calcium-regulated protein which correlates to a specific functional state of these cells. PMID: 19365806