Recombinant Human Cyclic AMP-dependent transcription factor ATF-7(ATF7)

Code CSB-EP002279HU
Product Type Recombinant Protein
Size US$2466
Uniprot No. P17544
Relevance Plays important functions in early cell signaling. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AG][AG]-3'), a sequence present in many viral and cellular promoters. Activator of the NF-ELAM1/delta-A site of the E-selectin promoter. Has no intrinsic transcriptional activity, but activates transcription on formation of JUN or FOS heterodimers. Also can bind TRE promoter sequences when heterodimerized with members of the JUN family. Isoform 4 acts as a dominant repressor of the E-selectin/NF-ELAM1/delta-A promoter. Isoform 5 acts as a negative regulator, inhibiting both ATF2 and ATF7 transcriptional activities. It may exert these effects by sequestrating in the cytoplasm the Thr-53 phosphorylating kinase, preventing activation.
Image
  • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Storage Buffer Tris-based buffer,50% glycerol
Alias Activating transcription factor 7 Transcription factor ATF-A
Species Homo sapiens (Human)
Purity Greater than 90% as determined by SDS-PAGE.
Sequence MGDDRPFVCNATGCGQRFTNEDHLAVHKHKHEMTLKFGPARTDSVIIADQTPTPTRFLKNCEEVGLFNELASSFEHEFKKAADEDEKKARSRTVAKKLVVFRPRLFLLCFGIIFLIG
Research Area Epigenetics and Nuclear Signaling
Source E.coli
Gene Names ATF7
Protein Names Recommended name: Cyclic AMP-dependent transcription factor ATF-7 Short name= cAMP-dependent transcription factor ATF-7Alternative name(s): Activating transcription factor 7 Transcription factor ATF-A
Expression Region 1-117aa
Tag Info N-terminal GST-tagged
Mol. Weight 40.3kDa
Protein Description Full Length of BC042363
Storage The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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Function Plays important functions in early cell signaling. Binds the cAMP response element (CRE) (consensus
Subcellular Location Nucleus, Nucleus, nucleoplasm
Protein Families BZIP family
Tissue Specificity Expressed in heart, lung and skeletal muscle. Isoform 4 is expressed in various tissues including heart, brain, placenta, lung and skeletal muscle. Highest levels in skeletal muscle. Lowest in lung and placenta.
Database Links

HGNC: 792

OMIM: 606371

KEGG: hsa:11016

STRING: 9606.ENSP00000329212

UniGene: Hs.12286

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