ATF7 Antibody

Code CSB-PA000950
Size US$167
Image
  • Western Blot analysis of HuvEc cells using ATF-7 Polyclonal Antibody
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Product Details

Uniprot No. P17544
Target Names ATF7
Alternative Names 1110012F10Rik antibody; 9430065F09Rik antibody; Activating transcription factor 7 antibody; AI549878 antibody; ATF7 antibody; Atf7 protein antibody; ATF7_HUMAN antibody; ATFA antibody; C130020M04Rik antibody; cAMP-dependent transcription factor ATF-7 antibody; Cyclic AMP-dependent transcription factor ATF 7 antibody; Cyclic AMP-dependent transcription factor ATF-7 antibody; MGC31554 antibody; MGC57182 antibody; Transcription factor ATF A antibody; Transcription factor ATF-A antibody
Raised in Rabbit
Species Reactivity Human,Mouse
Immunogen Synthesized peptide derived from the Internal region of Human ATF-7.
Immunogen Species Homo sapiens (Human)
Conjugate Non-conjugated
Isotype IgG
Purification Method The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Form Liquid
Tested Applications WB, IHC, IF, ELISA
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:2000
IHC 1:100-1:300
IF 1:200-1:1000
ELISA 1:20000
Protocols Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
ELISA Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Target Data

Function Plays important functions in early cell signaling. Binds the cAMP response element (CRE) (consensus
Gene References into Functions
  1. ATF7 is a direct target of miR-103a-3p. In a stomach cancer cohort,miR-103a-3p expression was inversely correlated with ATF7 expression. Silencing ATF7 showed similar cellular and molecular effects as miR-103a-3p overexpression, namely, increased GC cell proliferation, improved CDK2 expression and decreased P27 expression. PMID: 29754469
  2. knockdown of the mammalian homologs of PDK1 and ATF7 in HEK293 cells resulted in changes in metallothionein expression, suggesting that this pathway was evolutionarily conserved PMID: 28632756
  3. CARMA1- and MyD88-dependent activation of Jun/ATF-type AP-1 complexes is a hallmark of ABC diffuse large B-cell lymphomas. PMID: 26747248
  4. mitotic stabilized ATF7 protein re-localizes onto chromatin at the end of telophase and contributes to induce the cyclin D1 gene expression. PMID: 26101806
  5. It is negatively related between ATF7 expression and pathological stage and positive correlation with OS and PFS in CRC. ATF7 expression is a favorable factor for survival of patients with CRC. PMID: 26148593
  6. These results suggest that the Cdk1-mediated phosphorylation of ATF7 facilitates G2/M progression, at least in part, by enabling Aurora signaling. PMID: 25545367
  7. ATF7 interacts with TAF12 and contributes to the hypersensitivity of OCL precursors to 1,25-(OH)D in PD. PMID: 23426901
  8. Data show that ATF7-4 is an important cytoplasmic negative regulator of ATF7 and ATF2 transcription factors. PMID: 21858082
  9. The authors characterized the multisite phosphorylation of the ATF7 activation domain and identified one of the involved kinase, p38beta2 mitogen-activated protein kinase. PMID: 18950637

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Subcellular Location Nucleus, Nucleus, nucleoplasm
Protein Families BZIP family
Tissue Specificity Expressed in heart, lung and skeletal muscle. Isoform 4 is expressed in various tissues including heart, brain, placenta, lung and skeletal muscle. Highest levels in skeletal muscle. Lowest in lung and placenta.
Database Links

HGNC: 792

OMIM: 606371

KEGG: hsa:11016

STRING: 9606.ENSP00000329212

UniGene: Hs.12286

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