Recombinant Human Cytochrome P450 2W1 (CYP2W1)

1. showed that the genetic pattern of CYP2W1 is interethnically different among the three Chinese populations, and this finding can extend our understanding of population genetics of CYP2W1 in the Chinese population PMID: 27307299
2. summarizes the history, distribution, polymorphism, membrane topology, function and possible role in cancer therapy of CYP2W1. PMID: 27257736
3. Normal adrenal tissue lacks CYP2W1 enzyme expression; adrenocortical carcinomas generally do not express the enzyme as well. PMID: 27598485
4. Report novel SNPs of CYP2W1 gene in Chinese Uygur and Han populations. PMID: 26683388
5. Data suggest that canonical cytochrome P-450 reductants (cytochrome P450 reductase; cytochrome b5) cannot serve as electron donors for CYP2W1, a colon tumor-specific enzyme; glycosylation of CYP2W1 at Asn177 is required for full catalytic activity. PMID: 26787547
6. Results show the developmental expression of CYP2W1 in the GI tract mediated by epigenetic modifications, its specific location, and regulation by anticancer drugs which can be considered as an adjuvant therapy of colon and hepatic cancers. PMID: 25844926
7. Low KRT13 mRNA expression is associated with oral squamous cell carcinoma. PMID: 25735388
8. CYP2W1 is highly expressed in both normal and neoplastic adrenal glands making it a promising tool for targeted therapy in ACC PMID: 25144458
9. High CYP2W1 expression is seen in 26% of primary colorectal tumors and in 48% of corresponding liver metastases. PMID: 24625228
10. CYP2W1 could play an important role in hepatocellular carcinoma (HCC) and might serve as a valuable prognostic marker and potential target for gene therapy in the treatment of HCC. PMID: 24801906
11. No significant differences in the distribution of CYP2W1*1, CYP2W1*2 and CYP2W1*6 alleles were found between CRC patients and controls. PMID: 24088132
12. Results of the current study were in agreement with those of the previous pilot study and show that higher expression of CYP2W1 seems to be of prognostic value in colon cancer. PMID: 22993331
13. study did not detect an association between the CYP2W1, 4F11 and 8A1 genes polymorphisms and breast cancer risk in a Mexican population; however, some clinico-pathological risk factors interact with CYP2W1 genotypes and modifies susceptibility to breast cancer PMID: 22631658
14. a role for human cytochrome P450 2W1 in selective oxidation of lysophospholipids PMID: 22591743
15. CYP2W1 variant alleles are common among Caucasian individuals and, of these, the CYP2W1 G541A (Ala181Thr) polymorphism is associated with increased colorectal cancer risk. PMID: 20602611
16. CYP2W1 is catalytically active in the transformation of aflatoxin B1 to cytotoxic products and in the metabolism of indolines, indicating functional intracellular electron transfer. PMID: 20805301
17. CYP2W1 is expressed human colonic and adrenal gland neoplasms, but not normal tissue, and is expressed in rat fetal and adult colon PMID: 16426568
18. The expression of CYP2W1 is colon tumor-specific and is associated with methylation status of the CYP2W1 gene, suggesting a potential causal link between the gene hypomethylation and its enhanced expression. PMID: 17979506
19. Six single nucleotide polymorphisms of CYP2W1 were identified in a Japanese population. PMID: 17998294

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HGNC: 20243

OMIM: 615967

KEGG: hsa:54905

STRING: 9606.ENSP00000310149

UniGene: Hs.272795