Cytoskeleton-associated protein 5 (CKAP5), also known as ch-TOG or XMAP215, is a crucial member of the XMAP215/Dis1 family, playing a critical role in regulating microtubule polymerization [1]. CKAP5 protects kinetochore microtubules from depolymerization and is involved in the assembly of central microtubules [2]. It is a highly conserved cytoskeleton-associated factor that regulates various aspects of microtubule function, including promoting microtubule nucleation, binding to their growing ends, sustaining their elongation, and regulating their dynamics [3][4]. CKAP5 binds to the plus ends of microtubules, regulating bipolar spindle formation and centrosomal organization during mitosis [5][6]. Additionally, CKAP5 plays a critical role in mitotic cell cycle by organizing mitotic spindles [7]. It is also involved in spindle assembly in mouse oocytes and prevents irreversible multipolarity by ensuring spindle-pole resistance to traction forces during chromosome alignment [6][8]. Furthermore, CKAP5 may function during the infection cycle of influenza A virus to organize microtubules for the trafficking of viral components [9].
References:
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