Recombinant Human DNA repair protein XRCC2 (XRCC2)

1. XRCC2 rs3218408 was related with increased risk of colorectal cancer. PMID: 29748531
2. Results identified a significant relationship between SNP rs3218536 of XRCC2 and an increased risk of endometrial cancer development. PMID: 30194171
3. Truncating variants in PALB2, ATM and CHEK2 , but not XRCC2 were associated with increased breast cancer risk. PMID: 28779002
4. meta-analysis indicates that XRCC2 rs3218536 and ERCC2 rs13181 polymorphisms may not be associated with the risk of ovarian cancer PMID: 27863412
5. Study has shown that most rare XRCC2 missense variants have little effect on XRCC2 protein function and are unlikely to be associated with familial and early-onset breast cancer. PMID: 27233470
6. involvement of ZNF281 in the cellular response to genotoxic stress through the control exercised on the expression of genes that act in different repair mechanisms PMID: 26300006
7. XRCC2 is shown to be the 20th Falconi anemia (FA) gene and is 2nd RAD51 paralog so identified. XRCC2 is required to maintain levels of other RAD51 paralogs that are normally present in XRCC2-RAD51B-C-D complex. PMID: 27208205
8. Polymorphism of XRCC2 gene is associated with Nasopharyngeal Carcinoma. PMID: 27356695
9. Results indicate that homologous recombination repair genes XRCC2 Arg188His and XRCC3 Thr241Met polymorphisms may be positively associated with the incidence of ovarian carcinoma in the population of Polish women. PMID: 26801223
10. Suggest that XRCC2 is a useful predictive biomarker of preoperative radiotherapy treatment response in locally advanced rectal cancer patients. PMID: 26320178
11. The XRCC2 Arg188His polymorphism was associated with the risk of ovarian cancer. (Meta-analysis) PMID: 26400309
12. The aim of the present study was to evaluate the relationship between prostate cancer risk and the presence of single nucleotide polymorphisms in the genes involved in Homologous recombination repair, RAD51, RAD51B, XRCC2 and XRCC3. PMID: 26339569
13. In conclusion, XRCC2 Arg188His and XRCC3 Thr241Met polymorphisms may be regarded as predictive factors of triple-negative breast cancer in female population. PMID: 24728564
14. XRCC2 protein expression of colorectal cancer Chinese Han patients with CT/TT genotypes were significantly higher than CC genotype. PMID: 25304007
15. The GA genotype of the Arg188His polymorphism of XRCC2 was associated with increased risk of breast cancer in a Pakistani cohort. PMID: 25556451
16. Single nucleotide changes were studied in XRCC2 and XRCC3 genes at locus Arg188His and Thr241Met in stomach cancer patients who lived in North Eastern Turkey and in controls. PMID: 25428673
17. Links the SNP -41657C/T (rs718282) of the XRCC2 gene with endometrial carcinoma in Polish women. PMID: 26017882
18. Our data suggests that deregulation of XRCC2 in breast cancer has the potential to predict lymph node metastasis PMID: 25159888
19. A relationship was identified between XRCC2-41657C/T polymorphism and the incidence of ovarian cancer. PMID: 25355640
20. impact of XRCC2 Arg188His polymorphism on cancer susceptibility PMID: 24621646
21. Interaction of tobacco and polymorphisms of XRCC1 and XRCC2 increases the risk of head and neck squamous cell carcinoma in northeast Indian population.The XRCC2 Arg188His polymorphism was associated with increased risk of this cancer. PMID: 24958516
22. High XRCC2 expression promotes CRC cell proliferation and enriches cells in the G0/G1 phase but inhibits apoptosis. PMID: 25526472
23. Our data suggest that the suppression of XRCC2 expression rendered colon tumor cells more sensitive to radiation therapy in vitro and in vivo. PMID: 24481064
24. Genetic variants in XRCC2 are not associated with soft-tissue sarcoma. PMID: 24189466
25. current meta-analysis indicated that the Arg188His polymorphism in the XRCC2 gene might be a risk factor for ovarian cancer PMID: 24414483
26. Studied whether the double strand break gene polymorphisms XRCC2 R188H G>A (rs3218536), XRCC3 T241M C>T (rs861539) and R243H G>A (rs77381814) are associated with cervical cancer in Argentine women. PMID: 23539294
27. Our data do not confirm an association between XRCC2 variants and breast cancer risk, although a relative risk smaller than two could not be excluded. PMID: 23054243
28. polymorphisms in XRCC2 do not contribute to cancer risk in a population of Lynch syndrome patients with colorectal cancer PMID: 21974800
29. The results support the hypothesis that polymorphism of XRCC2 may be associated with the incidence of sporadic breast cancer in Polish women. PMID: 22611952
30. The identification of XRCC2 as a breast cancer susceptibility gene thus increases the proportion of breast cancers that are associated with homologous recombination-DNA-repair dysfunction and Fanconi anemia. PMID: 22464251
31. These findings suggest that XRCC2 SNPs may influence breast cancer risk and survival. PMID: 21632523
32. The Arg188His polymorphism of the XRCC2 gene can modify the risk of colorectal cancer. PMID: 21104022
33. Data show that XRCC2 and other homologous recombination proteins, including the key recombinase RAD51, co-localize with the centrosome, potentially to coordinate the deployment of a DNA damage response at vulnerable phases of the cell cycle. PMID: 21276791
34. the present meta-analysis suggests that the XRCC2 Arg188His is not directly associated with breast cancer risk PMID: 20127279
35. An important function of XRCC2 is to enhance the activity of RAD51, so that the loss of XRCC2 results in a severe delay in the early response of RAD51 to DNA damage. PMID: 20189471
36. may influence the repair capacity of breast cancer patients and, in turn, confer genetic predisposition to disease PMID: 20004634
37. Homologous pairing and ring and filament structure formation activities of the human Xrcc2*Rad51D complex. PMID: 11834724
38. a critical role in homologous recombination repair PMID: 14645207
39. hXRCC2 enhances ADP/ATP processing and strand exchange by hRAD51 PMID: 15123651
40. Finds no association between XRCC2 R188H polymorphism and risk of colorectal adenoma. PMID: 15184273
41. Considering that the XRCC2 (R188H) allele reduces risk to epithelial ovarian cancer, the increased XRCC2 activity with the R188H polymorphism may have clinical benefit in preventing cancer risk. PMID: 17141189
42. possible association of single nucleotide polymorphism at the 41657C/T position and 4234G/C position of XRCC2 with susceptibility to esophageal squamous cell carcinoma (ESCC) and gastric cardiac adenocarcinoma (GCA) PMID: 17922422
43. polymorphism may be one of the genetic modifiers for smoking-related pancreatic cancer PMID: 17986315
44. investigated the possible association of three SNPs, XRCC2 C41657T, XRCC2 G4234C and XRCC3 A17893G with susceptibility to esophageal squamous cell carcinoma and gastric cardia adenocarcinoma in a population of northern China PMID: 18046624
45. Findings suggest that the heterozygous and homozygous T allele of the XRCC4 G-1394T may be associated with the development of breast cancer PMID: 18383855
46. The snp XRCC2 rs3218536 showd some evidence of a protective association for the rare allele in progesterone receptor positive breast neoplasms. PMID: 19064565
47. Investigation supports a role for XRCC2 in colorectal cancer tumorigenesis, conferring susceptibility to rectal tumors. PMID: 19690184
48. Observational study and meta-analysis of gene-disease association and gene-environment interaction. (HuGE Navigator) PMID: 19127255

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HGNC: 12829

OMIM: 600375

KEGG: hsa:7516

STRING: 9606.ENSP00000352271

UniGene: Hs.647093