Product Details

Purity

>85% (SDS-PAGE)

Target Names

XRCC3

Uniprot No.

O43542

Alternative Names

CMM6; DNA repair protein XRCC3; RAD51 like; X ray repair complementing defective repair in Chinese hamster; X ray repair complementing defective repair in Chinese hamster cells 3; X ray repair cross complementing protein 3; X-ray repair cross-complementing protein 3; XRCC 3; XRCC3; XRCC3_HUMAN

Species

Homo sapiens (Human)

Expression Region

1-346

Target Protein Sequence

MDLDLLDLNPRIIAAIKKAKLKSVKEVLHFSGPDLKRLTNLSSPEVWHLLRTASLHLRGSSILTALQLHQQKERFPTQHQRLSLGCPVLDALLRGGLPLDGITELAGRSSAGKTQLALQLCLAVQFPRQHGGLEAGAVYICTEDAFPHKRLQQLMAQQPRLRTDVPGELLQKLRFGSQIFIEHVADVDTLLECVNKKVPVLLSRGMARLVVIDSVAAPFRCEFDSQASAPRARHLQSLGATLRELSSAFQSPVLCINQVTEAMEEQGAAHGPLGFWDERVSPALGITWANQLLVRLLADRLREEEAALGCPARTLRVLSAPHLPPSSCSYTISAEGVRGTPGTQSH

Protein Length

Full length protein

Tag Info

Tag type will be determined during the manufacturing process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Form

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Buffer before Lyophilization

Tris/PBS-based buffer, 6% Trehalose.

Reconstitution

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.

Troubleshooting and FAQs

Protein FAQs

Storage Condition

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Lead Time

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Datasheet

Please contact us to get it.

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Customer Reviews and Q&A

■ Customer Reviews

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■ Q&A

Would the protein be stable if I buffer-exchange it with 1X PBS buffer?

PBS buffer protein has not been delivered at present. Theoretically, dialysis replacement with PBS buffer will not lead to protein instability.
If you require PBS buffering, we can try dialysis to change the buffer and the lead time is 5-7 working days.
If the protein is unstable during dialysis, we can also prepare a new batch of PBS buffer protein for customers. Lead time is 13-20 working days.

Target Background

Function

Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions. Part of the RAD21 paralog protein complex CX3 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, CX3 acts downstream of RAD51 recruitment; the complex binds predominantly to the intersection of the four duplex arms of the Holliday junction (HJ) and to junctions of replication forks. Involved in HJ resolution and thus in processing HR intermediates late in the DNA repair process; the function may be linked to the CX3 complex and seems to involve GEN1 during mitotic cell cycle progression. Part of a PALB2-scaffolded HR complex containing BRCA2 and RAD51C and which is thought to play a role in DNA repair by HR. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51 and RAD51C.

Gene References into Functions

Although XRCC3 plays a role in asthma etiology, the variant XRCC3 genotypes do not serve as practicable predictive markers for asthma risk in Taiwanese. PMID: 30150425
Our results indicated a link between ERCC1 rs3212986 and the onset of late gastrointestinal toxicity ..No association was found regarding the XRCC3 rs861539 polymorphism and any clinical toxicity event PMID: 28708208
XRCC3 gene SNPs could influence the tumour aggressiveness expressed by tumour grade in hepatocellular carcinoma. PMID: 29895130
XRCC3 deleterious variants were identified in breast and ovarian cancer cases. PMID: 29255180
hypermethylation of homologous recombination DNA repair genes including RAD51B and XRCC3 is associated with an inflamed phenotype in squamous cell cancers of the head and neck, lung and cervix. PMID: 27683114
The combined AA/AA genotype and GG/GA genotype frequencies for rs1799794 and rs709399 polymorphisms were significantly higher in thyroid cancer patients compared to control group when compared with combined AA/GG genotype as reference. PMID: 28490032
based on the evidence from the large-scale case-control study and meta-analysis, the rs861539 within XRCC3 gene was associated with the risk of NPC under recessive model. PMID: 27639382
our study suggested that the polymorphism of rs861539 in XRCC3 was associated with increased risk of PTC. PMID: 26264616
XRCC3-Met allele seems to contribute to the development of OSCC, metastases and more advanced stages in these lesions. PMID: 26742000
This meta-analysis suggested that the XRCC3 rs861539 polymorphism was not a risk factor for cutaneous melanoma susceptibility. [meta-analysis] PMID: 26922354
XPD Lys751Gln polymorphism may be a risk factor for CCRCC. Regarding the XRCC3 Thr241Met polymorphism, an association with CCRCC was found only in XRCC3 Thr241Met/XPD Lys751Gln combined genotypes. PMID: 26682510
XRCC3 T241M polymorphism may constitute a risk factor for hepatocellular carcinoma in the Chinese population (Meta-Analysis) PMID: 26662391
the results obtained during this study suggest that rs1799794 in XRCC3 shows strong association with breast cancer development in Saudi females. PMID: 26881229
XRCC3 Thr241Met polymorphism is associated with an increased risk of thyroid cancer in the overall population PMID: 26687776
XRCC3 rs861539 TT is a potential predictive marker for triple-negative breast cancer in Taiwanese women PMID: 26543082
our study firstly reports that XRCC3 Thr241Met gene polymorphism is associated with an elavated risk of osteosarcoma. PMID: 26662447
XRCC3 Thr241Met gene polymorphism was associated with increased risk of osteosarcoma PMID: 26617908
Our findings demonstrated that the T241M polymorphism in the XRCC3 gene may not be a risk factor for colorectal cancer development. PMID: 26600544
The rs861539 and rs3212112 polymorphisms in the XRCC3 gene may influence the risk of glioma development in a Chinese population. PMID: 26400288
XRCC3 Thr241Met polymorphism might be associated with breast cancer risk, especially in Asian populations and in patients without family history of breast ca [meta-analysis] PMID: 26498491
results indicate that Thr241Met polymorphism was not associated with the development of laryngeal cancer in Turkish population. PMID: 25510985
XRCC3 may be a novel radiosensitivity predictor and promising therapeutic target for esophageal squamous cell carcinoma PMID: 26383967
XRCC3 deregulation is extensively involved in the chemoresistance mechanisms in rectal cancer patients. PMID: 26023803
The T allele (CT and TT genotypes) of XRCC3 rs861539 contributes to increased risk of leiomyoma among Taiwanese women and may serve as a early detection and predictive marker. PMID: 26254358
Association between XRCC3 polymorphisms and the risk of radiation-induced normal tissue adverse effects. [meta-analysis] PMID: 26091483
XRCC3 gene rs861539 polymorphism was associated with the risk for gastric cancer in Asian populations. PMID: 25973083
The XRCC3 genotype and allele frequencies were not significantly different between gastric cancer patients and controls in a North India population. PMID: 25642794
XRCC3 Thr241Met polymorphism was associated with increased risk of colorectal cancer. PMID: 25824748
XRCC3 gene polymorphism is not correlated with the radiotherapy-based multimodality treatment in rectal cancer. PMID: 25684513
the XRCC3 Thr241Met genetic variant is associated with prostate cancer risk. PMID: 25834539
CT and TT genotypes of XRCC3 rs861539 were associated with increased lung cancer risk. PMID: 26124335
The frequency of heterozygous and homozygous genotype of Thr241Met polymorphism of XRCC3 were significantly higher in Pakistani breast cancer patients. PMID: 25556451
The XRCC3 gene polymorphism was not found to be associated with the risk of oral cancer. [Meta-Analysis] PMID: 25556470
The Thr241Met polymorphism of XRCC3 was associated with a 16 fold increase in head and neck cancer risk. PMID: 25556492
This study displayed a significantly elevated risk for colorectal cancer in individuals with XRCC3 Thr/Met and Met/Met Genotype of about 2.5 times that with the Thr/Thr wild genotype. PMID: 25520078
XRCC3 T241M polymorphism may not be a risk factor for lung cancer. PMID: 25501160
The T allele of XRCC3 rs861539, interacts with smoking habit in increasing nasopharyngeal carcinoma(NPC) risk, may be an early detection marker for NPC. PMID: 25687493
This meta-analysis provides evidence that the RAD51 and XRCC3 polymorphisms are not associated with an increased risk of AML in the total population. PMID: 23978154
the aim of this study was to evaluate the clinical response to platinum-based chemotherapy and treatment outcome of gastric cancer patients in the present of ERCC1, ERCC2, NBN, RAD51, and XRCC3 gene polymorphisms. PMID: 25542228
Association of DNA repair genes XRCC1 (Arg399Gln), (Arg194Trp) and XRCC3 (Thr241Met) polymorphisms with the risk of breast cancer: a case-control study in Egypt. PMID: 25340946
XRCC3 Thr241Met may act as a favorable prognostic indicator for lung squamous cell carcinoma patients. PMID: 23443124
This meta-analysis suggests that the T241M polymorphism of the XRCC3 gene confers a weakly increased breast cancer risk. PMID: 25169497
There is no clear evidence showing a significant correlation between XRCC3 Thr241Met polymorphism and lung cancer risk in total population and stratified analysis by ethnicity. PMID: 25794597
our results did not confirm the hypothesis of a possible role of NBN and XRCC3 SNPs in acute lymphoblastic leukaemia risk. PMID: 25176580
there was no association between XRCC3 Thr241Met (rs861539) polymorphism and leukemia risk in the overall population, but significant association between XRCC3 Thr241Met (rs861539) polymorphism and leukemia risk was found in the Asian population. PMID: 24304418
Studied the relation between XRCC3 Thr241Met polymorphism and lung cancer susceptibility of populations in East Asia. PMID: 25066399
findings have suggested that APE1, XRCC3, XPD, and hOGG1 gene variants could facilitate the development of migraine disease. PMID: 24892639
XRCC3 were associated with ovarian cancer risk overall for Caucasians. PMID: 25006581
XRCC3 single nucleotide polymorphism and gene frequency in Russians, Tatars and Bashkirs. PMID: 25474887
present meta-analysis demonstrates that XRCC3 C18067T polymorphism was not associated with risk of cutaneous melanoma but contributed a decreased risk to both basal cell carcinoma and squamous cell carcinoma PMID: 24454720

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Involvement in disease

Breast cancer (BC); Melanoma, cutaneous malignant 6 (CMM6)

Subcellular Location

Nucleus. Cytoplasm. Cytoplasm, perinuclear region. Mitochondrion. Note=Accumulates in discrete nuclear foci prior to DNA damage, and these foci persist throughout the time course of DNA repair.

Protein Families

RecA family, RAD51 subfamily

Database Links

HGNC: 12830

OMIM: 114480

KEGG: hsa:7517

STRING: 9606.ENSP00000343392

UniGene: Hs.592325

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Recombinant Human DNA repair protein XRCC3 (XRCC3)

Product Details

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Target Background

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