Recombinant Human Deleted in malignant brain tumors 1 protein (DMBT1), partial

1. Present study indicated that DMBT1 is upregulated in stools of colorectal cancer (CRC) patients, while exhibiting variable expression in CRC tissues. Loss of DMBT1 protein in CRC tissues is significantly associated with adverse clinicopathological features (advanced stage, lymph node or distant metastasis and high histological grade). PMID: 29498404
2. We investigated whether PRH1 and PRH2 polymorphisms in saliva acidic proline-rich protein (PRP) receptors for indigenous bacteria match and predict individual differences in the development of caries..They instead developed 3.9-fold more caries than P1 children from plaque accumulation in general when treated with orthodontic multibrackets; and had basic PRP polymorphisms and low DMBT1-mediated S. mutans adhesion PMID: 29191562
3. We found that in 3 different populations, mucosal DMBT1 expression was significantly increased (2.5 fold) in individuals with dysplasia compared to multifocal atrophic gastritis without intestinal metaplasia; the increase was also observed in individuals with advanced gastritis and positive H. pylori infection. PMID: 28423364
4. DMBT1 is expressed differently in cholangiocarcinogenesis and poorer patients' survival rates are associated with absent DMBT1 expression in non-neoplastic biliary tissue, suggesting a tumour-suppressive role of DMBT1 in early cholangiocarcinogenesis PMID: 28130841
5. we conclude that DMBT1 by binding with CRNDE and c-IAP1 associated with PI3K-AKT pathway is crucial for GBC carcinogenesis, and targeting this pathway may be pivotal in the treatment of GBC. PMID: 27637083
6. Studies indicate that salivary scavenger and agglutinin (SALSA) binds to many microbes and endogenous complement components. PMID: 28668353
7. The data suggest that DMBT1 inhibition of twitching motility contributes to the mechanisms by which mucosal fluids protect against P. aeruginosa infection. PMID: 28489917
8. this study shows that SAG inhibits the Interaction of DC-SIGN and Langerin with oral microorganisms PMID: 27082983
9. These results support the hypothesis that genetic variation in DMBT1 may influence microbial defense. PMID: 28364129
10. DMBT1 DNA copy number variation does not affect susceptibility to Crohn's disease in Northern Europeans. PMID: 26813944
11. this study shows that salivary agglutinin modulates the lectin pathway of the complement system PMID: 27048414
12. DMBT1 can potentially serve as a biomarker for early Acute respiratory distress syndrome diagnosis and disease severity assessment. PMID: 27565730
13. The copy number variation at DMBT1 does not affect risk of developing age-related macular degeneration and can therefore be ruled out from future studies investigating the association of structural variation at 10q26 with age-related macular degeneration. PMID: 27416785
14. The basal and meconium-induced NO production in lung epithelial cells is positively regulated by DMBT1. PMID: 27628193
15. SALSA, together with fibronectin and C1q, may be involved in the containment of injured placental structures into fibrinoids. PMID: 26828433
16. The DMBT1 may play a role in epithelial differentiation and local innate immunity during neonatal inflammatory bowel processes. PMID: 26542257
17. Data indicate that DMBT1 promotes VEGF and suppresses IL-6 production in alveolar tissues, which could point to DMBT1 having a possible role in the transition from inflammation to regeneration. PMID: 25885541
18. Gp340 expression patterns at these sites were also distinct. PMID: 26172445
19. multiallelic copy number variation (CNV) within DMBT1 is extensive across all populations. PMID: 25848046
20. gp340 exhibits varying functions in the different mucosal locations. PMID: 25320275
21. Oral streptococci adhere to tooth-immobilized glycoprotein 340 (GP340) via the surface protein antigen I/II as the first step in pathogenesis. Calcium increases the conformational stability of the scavenger-rich cysteine repeat domains of GP340. PMID: 24923446
22. A novel functional role of rs2981804 in regulating DMBT1 expression. PMID: 24223725
23. interaction between DMBT1(gp340) and trefoil TFFs proteins was investigated using an ELISA assay. DMBT1(gp340) bound to solid-phase bound recombinant dimeric TFF3 in a calcium dependent manner PMID: 23691218
24. Up-regulated DMBT1 and complement activation in cardiac amyloidosis may be part of the activated pathways induced by protein aggregation and the consecutive inflammatory reaction PMID: 23218398
25. DMBT1 is a component of breast milk after birth and is up-regulated in the breast milk from mothers with newborns suffering from neonatal infection. Thus, breast milk DMBT1 may be part of the innate immunity similar to secretory IgA. PMID: 23034003
26. rs2981745, a putative breast cancer risk locus, appears to be one of the causal variants leading to differential allele-specific expression in DMBT1. PMID: 23107584
27. a DMBT1 homozygous deletion is present in a fraction of diffuse astrocytomas and that it is associated with an unfavorable clinical outcome PMID: 22805772
28. Our data demonstrate that bacteria-related active inflammation results in a sharp increase of DMBT1 levels in enterocytes. PMID: 22296301
29. Disruption of expression in relation to tumor suppressors like DMBT1 and RUNX3 genes was associated with bladder cancer. PMID: 21956756
30. DMBT1 may play an important role in the proliferation of hepatic progenitor cells in HBV-related liver diseases. Down-expression of DMBT1 might enhance the risk of malignant transformation of hepatic progenitor cells. PMID: 22211283
31. a novel role for interleukin-27 (IL-27) as mediator of intestinal epithelial barrier protection mediated via DMBT1 and IDO1 PMID: 22069308
32. A higher content of gp-340 in the whole saliva of the youngest age-group (3-yr-olds) may reflect that this protein is a vital innate factor of immunity in children's saliva. PMID: 22112028
33. Data show that a significant difference of DMBT1 gene expression was detected between grade 1 and 3 bladder cancer, and the down-regulation of DMBT1 gene expression suggests the possible role in bladder cancer. PMID: 21999583
34. This provides the first evidence for a role of gp340 in complement activation through the mannose binding lectin pathway PMID: 21920605
35. The IL-22/DMBT1 axis may play a pivotal role in the pathophysiology of ulcerative colitis PMID: 20824812
36. oligosaccharide side chains of DMBT1 are recognized by the carbohydrate-recognition domain (CRD) of galectin 3 PMID: 21167898
37. Our study provides evidence that loss of DMBT1 expression is associated with prostate cancer, suggesting that DMBT1 may function as a tumor suppressor gene in prostate carcinogenesis PMID: 21167560
38. role in mucosal immunity to bacterial and viral infections; review PMID: 20418254
39. The data suggest that DMBT1 polymorphisms in the 5'-region are associated with increased breast cancer risk and decreased DMBT1 levels. PMID: 19830809
40. may be involved in terminal differentiation of prostate and vas deferens, but no evidence implicating role in prostatic carcinogenesis PMID: 11550206
41. DMBT1 is likely to play a differential role in the genesis of digestive tract carcinomas. PMID: 11751412
42. DMBT1 polymorphisms are not likely primary targets of 10q loss in malignant gliomas and do not support a major role for DMBT1 in gliomagenesis. PMID: 11912156
43. Identification of two highly sialylated human tear-fluid isoforms: the major high-molecular-mass glycoproteins in human tears PMID: 12015815
44. Identification of the bacteria-binding peptide domain PMID: 12050164
45. DMBT1 and p16 alterations occur in low-grade astrocytomas, and might be considered as early genetic events. PMID: 12168116
46. mutational analysis of the entire coding region of DMBT1, employing SSCP analysis and direct DNA sequencing in 79 astrocytic gliomas. Five somatic mutations were detected.21 of the 27 SNP identified in this study have not been recognized previously. PMID: 12185598
47. Changes of DMBT1 expression and location reflect a time course that point to possible mechanisms for its role in epithelial cancer. PMID: 12203780
48. Analysis of loss of heterozygosity in melanoma resection specimens PMID: 12239452
49. The repetitive scavenger receptor cysteine-rich (SRCR) domains and SRCR-interspersed domains (SID) of DMBT1 define a complex multi-allele system that represents the major basis for the variability of DMBT1 in cancer. PMID: 12353266
50. heterogeneity of ductular reactions in adult rat and human liver revealed by novel expression of this protein PMID: 12368192

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HGNC: 2926

OMIM: 137800

KEGG: hsa:1755

STRING: 9606.ENSP00000357905

UniGene: Hs.279611