Recombinant Human Disabled homolog 2 (DAB2)

1. Estrogen-induced miR-191 was identified as a direct upstream regulator of DAB2 in ER-positive breast cancer cells. PMID: 29247596
2. DAB2 is a frequent target of epigenetic silencing in oral carcinomas and may be potentially used for tumor detection PMID: 29254794
3. Dab2 Ser723 phosphorylation is a key molecular event in thrombin-stimulated inside-out signaling and platelet activation, contributing to a new function of Dab2 in thrombin signaling. PMID: 28876503
4. DAB2 might be involved in excessive aldosterone biosynthesis and correlate with specific clinical characteristics of aldosterone-producing adenoma patients. PMID: 28514805
5. the results indicated that substrate stiffness could regulate EMT of cervical cancer cell lines HeLa and SiHa at least partially through miR-106b and its downstream target DAB2. PMID: 28498390
6. DAB2 can suppress the ERK signaling, but correlate to have TGF-beta-induced epithelial-to-mesenchymal transition (EMT) in esophageal squamous cell carcinomas (ESCCs). PMID: 27036032
7. The various novel mechanisms are described by which Dab2 mediates an array of signaling events with vast physiological consequences. PMID: 27417122
8. In conclusion, DAB2 and Intelectin-1 are newly identified positive markers of mesothelioma and have potential to be included in future immunohistochemical marker panels for differentiation of epithelioid mesothelioma from pulmonary adenocarcinoma PMID: 28394802
9. abundances of megalin and Dab2 (p = 0.046) were reduced in infected placentas from women with LBW deliveries PMID: 27072056
10. Data show that miR106b was frequently up-regulated in human cervical carcinoma tumors and cell lines and inversely correlated with DAB2 expression. Its regulation in under TGF-beta1 which contributes to cell migration by targeting DAB2 in cervical carcinoma. PMID: 26769181
11. these findings reveal that DAB2 is critical for controlling inflammatory signaling during phenotypic polarization of macrophages PMID: 26927671
12. DAB2 regulated the cell migration associated genes in PC3 cells, and the differential DAB2 expression between LNCaP and PC3 cells was partly regulated by histone 4 acetylation. PMID: 26143155
13. Dab2 depletion also increases the rescued protein half-life of DeltaF508 CFTR by ~18% and ~91%, respectively PMID: 25879443
14. These results indicated that miR-93 plays an important role in the initiation and progression of NPC by targeting Dab2 and the miR-93/Dab2 pathway may contribute to the development of novel therapeutic strategies for NPC in the future. PMID: 25892549
15. DAB2 expression is decreased in Non-Small Cell Lung Cancer , and the frequent methylation event at sites -86 to 226 of the DAB2 gene could contribute to the downregulation of DAB2. PMID: 25719979
16. Attenuating Dab2 expression in K562 cells diminished TfR internalization and increased surface levels of TfR concomitantly with a decrease in Tf uptake and erythroid differentiation. PMID: 24889971
17. Results suggest that endogenous Dab2 exacerbates central nervous system inflammation, potentially acting to up-regulate reactive oxygen species expression in macrophages and microglia, and that it is of potential pathogenic relevance in multiple sclerosis PMID: 24252604
18. Numb specifically regulates NPC1L1-mediated cholesterol absorption both in human intestine and liver, distinct from ARH and Dab2, which selectively participate in LDLR-mediated LDL uptake. PMID: 25331956
19. Akt1 and Akt2 are involved in albumin endocytosis, and phosphorylation of Dab2 by Akt induces albumin endocytosis in proximal tubule epithelial cells. PMID: 25253241
20. The data support a model in which Dab2 regulates the domain localization of TbetaRI in the membrane, balancing TGF-beta signaling via the Smad and JNK pathways. PMID: 24648493
21. breast cancer cell was deficient in Dab2 expression and related receptor endocytosis-mediated TGF-beta depletion, which may contribute to the accumulation of TGF-beta in tumor microenvironment and the induction of immune tolerance. PMID: 24638085
22. miR-145 regulates the migration and invasion of highly invasive prostate cancer cells through targeting DAB2 gene PMID: 24846918
23. Aberrant hypermethylation and reduced expression of disabled-2 promote the development of lung cancers. PMID: 24002585
24. Reduced Dab2 or loss of Dab2 expression significantly correlates with lower classification of meningiomas and negatively correlates with the invasive ability of adjacent tissues. PMID: 24608456
25. Exposure to follicular fluid transiently increased the transcript levels of IL8 and PTGS2, and decreased the expression of SOD2, GPX3, DAB2, and NR3C1. TNF and IL6 levels were also decreased while those of NAMPT were unaffected. PMID: 24186266
26. Megalin and Dab2 were expressed in prostate and colon epithelial cells, which was markedly enhanced following treatment with retinoic acid PMID: 23909735
27. These data suggest that Dab2-mediated recruitment of EH domain proteins selectively drives the internalization of the Dab2 cargo, integrin b1. PMID: 22648170
28. Data indicate that disabled-2 (Dab2) sulfatide-binding motif contains two helices when embedded in micelles, reversibly binds to sulfatides with moderate affinity, lies parallel to the micelle surface. PMID: 22977233
29. The Dab2 gene is inactivated in part by DNA methylation, and the suppression of Dab2 expression by DNA methylation may play a role in the development of myelodysplastic syndrome. PMID: 23005040
30. These findings thereby define an adaptor-specific mechanism in the control of fibrinogen uptake and implicate that DAB2 is the key adaptor in the clathrin-associated endocytic complexes to mediate fibrinogen internalization. PMID: 22705885
31. inhibition of Dab2 decreases phosphorylation of SMAD-1, 5, and 8 PMID: 22898784
32. FCHO2 regulates the size of clathrin structures, and its interaction with Dab2 is needed for LDLR endocytosis under conditions of low AP2. PMID: 22323290
33. Dab2 mediates AP-2 independent recruitment of CFTR to CCVs in polarized human airway epithelial cells. PMID: 22399289
34. It was concluded that PKB/Akt is part of an endocytic machinery and it mediates albumin uptake through its interaction with Dab2. PMID: 22218591
35. Results indicate that miR-187 directly targeted Disabled homolog-2 (Dab2). PMID: 21725366
36. Dab2 is required for the TGFbeta-induced gene expression of angiogenic factors such as VEGF and FGF2 PMID: 22265793
37. Dab2 depletion increased the CFTR half-life ~3-fold, in addition to inhibiting CFTR endocytosis. PMID: 21995445
38. Expressions of Disabled-2 and Axin were concurrently reduced and correlated with the malignant phenotype of lung cancers. PMID: 21496867
39. Dab2 is part of an accommodation of the cell to the altered physicochemical conditions prevalent in mitosis, aimed at allowing endocytic activity throughout the cell cycle. PMID: 21097498
40. Loss of Dab2 expression, commonly observed in breast cancer, may facilitate TGFbeta-stimulated epithelial-to-mesenchymal transition (EMT), and therefore increase the propensity for metastasis. PMID: 21063401
41. DAB2 acts as a tumor suppressor by dictating tumor cell TGF-beta responses, identify a biomarker for squamous cell carcinomas progression. PMID: 20592473
42. Demonstrate frequent DAB2 promoter hypermethylation in nasopharyngeal carcinoma and support the putative tumour suppressor effect of DAB2. PMID: 20525238
43. two pools of Dab2 co-exist at the platelet surface, in both sulfatide- and integrin receptor-bound states, and their balance controls the extent of the clotting response PMID: 19956625
44. Data show that downregulation of myosin VI expression results in a significant reduction in PSA and VEGF secretion in LNCaP cells, and the intracellular targeting seems to involve myosin VI-interacting proteins, GIPC and LMTK2 and Dab2. PMID: 19855435
45. mechanism of growth inhibitory effect in prostate cancer PMID: 11812785
46. DOC2 has a role in regulating c-Src in prostatic epithelium and cancer PMID: 12473651
47. Results suggest that disabled-2 functions as a negative regulator of canonical Wnt signaling by stabilizing the beta-catenin degradation complex. PMID: 12805222
48. CIN85 association with Dab2 is essential for its recruitment to clathrin coat and appears to be modulated by growth factor stimulation PMID: 14596919
49. Loss in dab-2 expression is correlated with the loss of epithelial basement membrane in morphologically normal areas PMID: 14669280
50. a binding affinity of Dab phosphotyrosine interaction domain for megalin CT of K(D) = 2.6 x 10(-7) +/- 5.3 x 10(-8) PMID: 15134832

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HGNC: 2662

OMIM: 601236

KEGG: hsa:1601

STRING: 9606.ENSP00000313391

UniGene: Hs.696631