Recombinant Human Dual specificity protein phosphatase 4 (DUSP4)

1. This study was aimed to investigate the correlation of dual-specificity phosphatase 4 (DUSP4) expression with clinicopathologic features and overall survival in patients with GC and explore the effects of sanguinarine on tumour growth and invasion in GC cells (SGC-7901 and HGC-27) and underlying molecular mechanisms PMID: 27957827
2. Study revealed that DUSP4 expression was apparently downregulated in the deep region of colorectal cancer (CRC) tissues compared with the superficial region, and that ERK phosphorylation was conversely increased in the deep region relative to the superficial region. Also, downregulation of DUSP4 in CRC might promote cell proliferation and invasiveness through activation of ERK. PMID: 29150975
3. Results show that DUSP4 gene is under-expressed in ER-negative breast cancer and is deleted in approximately 50 % of breast cancers. Induced DUSP4 expression suppresses both in vitro and in vivo growths of breast cancer cells suggesting that DUSP4 is a critical regulator of the growth and invasion of triple-negative breast cancer cells. PMID: 27393618
4. Our findings demonstrate a genetic mechanism by which pancreatic precursor lesions progress to invasive carcinomas and highlight DUSP4 as a novel invasion suppressor PMID: 26941286
5. DUSP4 is crucial in regulating corticosteroid sensitivity. PMID: 28283554
6. Data indicate that normalization of dual-specific phosphatase 4 (DUSP4) expression using a specific siRNA improved CD4(+) T-cell activity in idiopathic CD4 lymphopenia (ICL). PMID: 25733583
7. Ectopic expression of wild-type DUSP4, but not of a phosphatase-deficient mutant, dephosphorylates c-JUN N-terminal kinase (JNK) and induces apoptosis in DLBCL cells. PMID: 25847947
8. Low DUSP4 expression levels predict recurrence and mortality in triple-negative breast cancer patients PMID: 25281216
9. Instead, autophagic cell death was the major consequence, and our investigation of mechanisms suggested it is mediated via the dual specificity phosphatase-4 (DUSP4) dependent ERK inactivation pathway PMID: 25027955
10. DUSP4 attenuates ERK signaling and reduces cell viability, suggesting that the novel crosstalk between NFkappaB and mitogen activated protein kinase pathways contributes to cell survival. PMID: 23812841
11. Enforced expression of DUSP4 reduced the CD44(+)/CD24(-) population in multiple BLBC cell lines in a MEK-dependent manner, limiting tumor formation of claudin-low SUM159PT cells in mice. PMID: 23966295
12. high DUSP4 expression was associated with a worse overall survival and with clinical characteristics typical for BRAF mutant patients PMID: 23875912
13. There was no significant correlation between DUSP4 expression and KRAS mutation. PMID: 23749251
14. Increased DUSP4 expression is associated with papillary thyroid carcinoma. PMID: 24222120
15. MKP2 is a negative regulator of VRK1-mediated histone H3 phosphorylation. PMID: 23223570
16. DUSP4 functions as part of a negative feedback mechanism in the control of the duration and magnitude of nuclear ERK activation during intestinal tumorigenesis. PMID: 22430215
17. High DUSP4 is associated with microsatellite instability in colorectal cancer and causes increased cell proliferation. PMID: 22965873
18. Dusp4 mediates cardiomyopathy caused by LMNA gene mutation. PMID: 23048029
19. Increased DUSP4 expression in activated T cells in the elderly in part accounts for defective adaptive immune responses. PMID: 22434910
20. MKP-2 is phosphorylated by ERK and that such phosphorylation leads to stabilization of MKP-2 protein. PMID: 21084841
21. presence of activating KRAS mutations is significantly correlated to an upregulation of 13 genes (adjusted P-value <0.05), among them DUSP4, a MAP-kinase phosphatase, and SMYD3, a histone methyltransferase PMID: 20725992
22. Over-expression of MKP-2 had different effects upon the expression of inflammatory proteins due to a reciprocal effect upon JNK and NFkappaB signalling, and also prevented TNF-alpha-mediated endothelial cell death PMID: 20860659
23. MKP-2 as a common epigenetically silenced gene in glioma, the inactivation of which may play a significant role in glioma development. PMID: 20124482
24. The occurrence of a novel splice variant of MKP-2 which is unable to bind ERK and may be significant in the dysregulation of MAP kinase activity in certain disease states. PMID: 19843478
25. Results demonstrate the in vivo specificity of MKP-2 for JNK and not ERK and show that nuclear-targeted JNK is involved in genotoxic stress-induced apoptosis. PMID: 16038800
26. MKP2-mediated inactivation of nuclear extracellular signal-regulated protein kinase ERK2 represents a key event in the establishment of replicative cell senescence. PMID: 17145763
27. E2F-1 is a transcriptional activator of MKP-2 and MKP-2 is an essential cell death mediator in the E2F-1 pathway PMID: 17452331
28. Crystal structure of the catalytic domain of human MKP-2 reveals a 24-mer assembly. PMID: 19415758
29. Results show that DUSP4 is involved in negative feedback control of EGFR signaling, and provide functional validation for its role as a growth suppressor in EGFR-mutant lung adenocarcinoma. PMID: 19525976

Show More

Hide All

HGNC: 3070

OMIM: 602747

KEGG: hsa:1846

STRING: 9606.ENSP00000240100

UniGene: Hs.417962