Recombinant Human E3 ubiquitin-protein ligase Topors (TOPORS), partial

1. A novel mutation of the TOPORS gene was identified, c.2539C>T p.(Arg847Ter), resulting in a premature termination codon and suggesting haploinsufficiency as the pathological mechanism. PMID: 28453362
2. P26s4 Associates with the C-Terminal Region of TOPORS. PMID: 26872363
3. Data suggest that TOPORS plays key role in turnover of H2AX (H2A histone family, member X protein) depending on the type of oxidative stress/DNA damage; TOPORS may act as an E3 ubiquitin ligase for histones. PMID: 22972498
4. Disturbed flow induces peroxynitrite production and binding to the E3 SUMO (small ubiquitin-like modifier) ligase PIASy (protein inhibitor of activated STATy). PMID: 21624951
5. In photoreceptors, TOPORS localizes primarily to the basal bodies of connecting cilium and in the centrosomes. PMID: 21159800
6. Polo-like kinase 1 (Plk1)-associated phosphorylation of Topors at S718 is essential for nocodazole-induced degradation of Topors. PMID: 19821153
7. We present a novel mutation in the TOPORS gene co-segregating with a distinct phenotype of adPRD in a large Norwegian family. PMID: 19183411
8. Topors, a p53 and topoisomerase I binding protein, interacts with the adeno-associated virus (AAV-2) Rep78/68 proteins and enhances AAV-2 gene expression PMID: 11842245
9. topors localizes in punctate nuclear regions associated with PML protein nuclear bodies. PMID: 12083797
10. Multiple SUMO-1 modified forms of Topors could be detected after cotransfection of exogenous SUMO-1 and Topors induced the colocalization of a YFP tagged SUMO-1 protein in a speckled pattern in the nucleus. PMID: 14516784
11. topors functions as a negative regulator of cell growth, and possibly as a tumor suppressor PMID: 15107820
12. topors has a role as an E3 ubiquitin ligase with specific E2 enzymes and ubiquitinates p53 PMID: 15247280
13. Results show that the ATR/checkpoint kinase 1 pathway plays a predominant role in the response to topoisomerase I inhibitors in carcinoma cells. PMID: 15699047
14. topors mediates p53-dependent cellular responses induced by DNA damage, suggesting its physiological role as a tumor suppressor PMID: 15735665
15. Data show that Topors enhances the conjugation of the small ubiquitin-like modifier 1 (SUMO-1) to p53 in vivo and in a reconstituted in vitro system. PMID: 16122737
16. The findings suggest that TOPORS may function as a tumor suppressor by regulating mSin3A and other proteins involved in chromatin modification. PMID: 17803295
17. Mutations in the gene for topoisomerase I-binding RS protein (TOPORS) in patients with autosomal dominant retinitis pigmentosa (adRP) linked to chromosome 9p21.1 (locus RP31), is reported. PMID: 17924349
18. Topors enhances the formation of high-molecular weight SUMO-1 conjugates of TOP1 in a reconstituted in vitro system and also in human osteosarcoma cells PMID: 17976381
19. NKX3.1 can be ubiquitinated by TOPORS in vitro and in vivo, and overexpression of TOPORS leads to NKX3.1 proteasomal degradation in prostate cancer cells PMID: 18077445
20. Point mutations and small insertions or deletions in TOPORS cause approximately 1% of autosomal dominant retinitis pigmentosa. PMID: 18509552
21. Mutations in TOPORS cause autosomal dominant retinitis pigmentosa (adRP). PMID: 19373681
22. Plk1 modulates Topors activity in suppressing p53 function PMID: 19473992

Show More

Hide All

HGNC: 21653

OMIM: 609507

KEGG: hsa:10210

STRING: 9606.ENSP00000353735

UniGene: Hs.589962