Recombinant Human Extracellular sulfatase Sulf-2 (SULF2), partial

Code CSB-YP810283HU
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Source Yeast
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Code CSB-EP810283HU
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Source E.coli
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Code CSB-EP810283HU-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP810283HU
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Source Baculovirus
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Code CSB-MP810283HU
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Source Mammalian cell
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Product Details

>85% (SDS-PAGE)
Target Names
Uniprot No.
Alternative Names
Extracellular sulfatase Sulf 2; Extracellular sulfatase Sulf-2; HSulf-2; HSulf2; Sulf2; SULF2_HUMAN
Homo sapiens (Human)
Protein Length
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Please contact us to get it.

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Target Background

Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C-6 position of glucosamine within specific subregions of intact heparin.
Gene References into Functions
  1. High SULF2 expression is associated with glioma. PMID: 29360432
  2. The activity of sulfatase 2, a major form of endosulfatase in hepatocellular carcinoma can be studied, in connection with the interactions between heparan sulfate and various growth factors. PMID: 28193024
  3. SULF2 promotes the growth and metastasis of CRC probably by activating Akt and Erk1/2 pathways. PMID: 28320104
  4. Although no change in SULF2 was detected in squamous cell carcinoma of the head and neck (HNSCC) serum, its detection in saliva makes it worthy of further investigation as a potential HNSCC biomarker. PMID: 27223083
  5. results demonstrated that SULF2 can mediate the detrimental effects of ionizing radiation in vivo PMID: 26895473
  6. The short variants of Sulf2 promoted FGF2-induced MDA-MB231 and MCF7 in vitro growth while full-length Sulf1 inhibited growth supporting in vivo mammary tumour cell signalling patterns of growth. PMID: 27294358
  7. Most pancreatic ductal adenocarcinomas had positive SULF2 staining in tumour cells and intratumoural or tumour-adjacent stroma. Elevated SULF2 in PDAC was associated with advanced tumour stage, vascular invasion, shorter interval to radiological progression and shorter overall survival. PMID: 27560551
  8. The SULF1/SULF2 activation thus does not only promote regulated foetal growth and injury-induced liver regeneration but also dysregulated tumour growth. PMID: 27013228
  9. Sulf2 facilitated lymphangiogenesis in breast cancer cells by regulating VEGF-D and that the AKT1related signaling pathway was involved. PMID: 27748846
  10. renal cell carcinoma with lower SULF-2 expression might have a higher potential for cell invasion and proliferation, leading to a poorer prognosis via the activation of VEGF and/or FGF signaling PMID: 27589337
  11. SULF2 is a multifaceted protein involved in triglyceride-rich lipoprotein homeostasis and angiogenesis. [review] PMID: 26959705
  12. Our data confirmed that Sulf2 promoted breast cancer progression and regulated the expression of tumor-related genes in breast cancer. PMID: 26708018
  13. Tumor expression of SULF2 may affect prognosis in NSCLC, while blood SULF2 levels may have a significant role in the diagnosis of this fatal disease. PMID: 26882224
  14. SULF2 have a pro-tumorigenic effect in DU-145 and PC3 cancer cells, suggesting an important role of this enzyme in prostatic cancer metastasis. PMID: 25887999
  15. Results show that SULF1 or SULF2 overexpression contributes to colorectal cancer cell proliferation, migration, and invasion. PMID: 25477293
  16. Substrate specificity of human SULF2. PMID: 25127119
  17. SULF2 blood levels increased with age in both healthy and cirrhosis patients.SULF2 blood level was higher in cirrhosis patients than healthy individuals. PMID: 25444749
  18. pectin induced the expression of HSulf-2 through the interaction with fibronectin, alpha5beta1 integrin, and ERK1/2 PMID: 25036960
  19. SULF2 expression in human tumor tissue and cell lines, was assessed. PMID: 25325976
  20. Our findings define Sulf-2 as a novel positive regulator of neuroblastoma pathogenicity that contributes to MYCN oncogenicity. PMID: 25164011
  21. The SULF2 single nucleotide polymorphism was reproducibly associated with lower fasting plasma triglycerides levels in obese type 2 diabetic subjects. PMID: 24339435
  22. Results indicate that the genetic variation rs2281279 in SULF2 associates with postprandial clearance of remnant TRLs and triglyceride levels in healthy subjects. PMID: 24278138
  23. SULF2 promoter methylation was associated with irinotecan sensitivity in gastric carcinoma. PMID: 24359226
  24. SULF1/SULF2 splice variants regulate pancreatic tumor progression. PMID: 24726914
  25. SULF2 methylation is negatively associated with cisplatin sensitivity in vitro. PMID: 24124496
  26. Knockdown of SULF2 in human corneal epithelial cell line slowed migration, which was restored by overexpression of either mouse SULF2 or human SULF1. PMID: 23950901
  27. Ectopic expression of SULF1 or SULF2 in HeLa cells, which decreases cell surface heparan sulfate proteoglycan sulfation, diminished Chlamydia muridarum binding and decreased vacuole formation. PMID: 23480519
  28. Sulf2 is overexpressed in idiopathic pulmonary fibrosis and may play a role in regulating TGF-beta1 signaling in type II alveolar epithelial cells. PMID: 23418199
  29. studied the functional consequences of HSulf-2 activity on fibroblast growth factor (FGF)-induced mitogenesis and found that the enzyme could differentially regulate FGF1 and FGF2 activities PMID: 23457216
  30. Sulf-2 expression is be critical for human breast cancer progression. PMID: 22410125
  31. genes and pathways modulated by epigenetic inactivation of SULF2 and the effects on sensitivity to chemotherapy were characterized in lung cancer in vitro and in vivo; silencing SULF2 primarily increased expression of interferon-inducible genes including ISG15 PMID: 22158045
  32. Heparan sulfate sulfatase SULF2 regulates PDGFRalpha signaling and growth in human and mouse malignant glioma PMID: 22293178
  33. enzymatic activity of HSulf2 PMID: 21347431
  34. This study demonstrates that unlike normal adult lung with little or no SULF2 expression, this enzyme is expressed at high levels in most lung tumours showing differential cellular distribution of full length and shorter SULF2 variants in such tumours. PMID: 21968018
  35. SULF1 and SULF2 are overexpressed in various human cancer types and can be associated to progression and prognosis. PMID: 21599997
  36. The prosurvival, anti-apoptotic effect of SULF2 in hepatocellular carcinoma is mediated through activation of the PI3K/Akt pathway. PMID: 21040406
  37. Loss of SULF2 is associated with breast cancer. PMID: 20707913
  38. Mechanism mediating the oncogenic function of SULF2 in human hepatoma that includes GPC3-mediated activation of Wnt signaling. PMID: 20725905
  39. Our findings support an essential role for Sulf-2 in lung cancer PMID: 19855436
  40. Sulfs are extracellular endosulfatases with strong potential for modulating the interactions of heparan sulfate proteoglycans in the extracellular microenvironment PMID: 12368295
  41. HSulf-1 and HSulf-2 have roles in inhibiting myeloma tumor growth PMID: 16192265
  42. Purified recombinant Sulf-2 promoted angiogenesis in the chick chorioallantoic membrane assay. PMID: 16331886
  43. Binding of VEGF, FGF-1, & certain chemokines (SDF-1 & SLC) to immobilized heparin was abolished or diminished by pre-treating the heparin with HSulf-2. Recombinant or native HSulf-2 released these soluble proteins from their association with heparin. PMID: 16417632
  44. Increased sulf-2 mRNA and protein levels may change the sulfation patterns of heparan sulfate proteoglycans and growth factor activities and thus contribute to abnormal chondrocyte activation and cartilage degradation in osteoarthritis. PMID: 18507859
  45. Sulf1 and Sulf2 are two heparan sulfate 6-O-endosulfatases that regulate the activity of multiple growth factors, such as fibroblast growth factor and Wnt, and are essential for mammalian development and survival PMID: 18687675
  46. Genetic and pharmacologic perturbation of p53 directly influences SULF2 expression in tumor cell lines. PMID: 19190338
  47. analysis of the subdomain organization of sulf-1 and sulf-2 PMID: 19520866
  48. HSulf-1 (SULF1) and HSulf-2 (SULF2) are potent inhibitors of myeloma tumor growth in vivo. PMID: 16192265

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Subcellular Location
Endoplasmic reticulum. Golgi apparatus, Golgi stack. Cell surface.
Protein Families
Sulfatase family
Tissue Specificity
Expressed at highest levels in the ovary, skeletal muscle, stomach, brain, uterus, heart, kidney and placenta.
Database Links

HGNC: 20392

OMIM: 610013

KEGG: hsa:55959

STRING: 9606.ENSP00000353007

UniGene: Hs.162016

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