Recombinant Human Ficolin-1 (FCN1)

1. M-ficolin interacts with A. fumigatus through interaction with chitin and beta-1,3 glucan and thereby mediates complement activation and potentiates IL-8 secretion of A549 cells. PMID: 28060571
2. higher ficolin-1 levels were associated with brain ischemic lesions and vasospasm following subarachnoid hemorrhage. PMID: 27734336
3. in northeastern Brazilian children and adolescents, FCN1 rs1071583 SNP was correlated with earlier age of type 1 diabetes mellitus (T1D) diagnosis; the SNP combination rs2989727 and rs1071583 was involved with T1D protection PMID: 27994205
4. Ficolin-1 could provide an alternative receptor-mediated mechanism for enhancing Ebola Virus infection, thereby contributing to viral subversion of the host innate immune system. PMID: 26984723
5. systemic lupus erythematosus patients with high ficolin-1 plasma levels had an increased risk of end-stage renal disease; there was no significant association between ficolin-1 and ficolin-3 with lupus nephritis PMID: 27981461
6. Ficolin-1 was decreased in patients compared with controls measured at 6 h (median 0.13 vs 0.33 mug/ml, respectively, p < 0.0001). At 48 h, ficolin-1 was significantly higher PMID: 26792363
7. Data indicate differences in the plasma concentrations of collectin liver 1 and collectin kidney 1, M-ficolin and H-ficol in systemic lupus erythematosus (SLE) patients compared to a group of healthy controls. PMID: 26154564
8. This study aims to investigate whether an association exists between the ficolins that are part of the lectin complement pathway and systemic lupus erythematosus. PMID: 25069872
9. the differential binding of ficolin-1 to lymphocyte subsets suggests ficolin-1 as a novel link between innate and adaptive immunity. PMID: 24161415
10. In patients with early rheumatoid arthritis, elevated plasma M-ficolin levels correlated with a high disease activity score at baseline and 1 year. A low M-ficolin level was the strongest predictor of remission and low disease activity. PMID: 24022747
11. Data show that a photodynamic therapy (PDT) dose-dependent upregulation of CRP gene, as well as of PTX3 and ficolin 1 genes in lung tumor A549 cells, and indicate critical role played by PI3K/Akt/AP-1 pathway. PMID: 23182717
12. These results demonstrate that ficolin-1 and PTX3 heterocomplex formation acts as a noninflammatory "find me and eat me" signal to sequester altered-host cells. PMID: 23817411
13. M-ficolin bound strongly to serotype 19B and 19C polysaccharides. PMID: 23184524
14. Study interlinks the genotype and phenotype relationship concerning polymorphisms in FCN1 and corresponding concentrations and biological functions of M-ficolin. PMID: 23209787
15. A genotype study of common promoter FCN1 single nucleotide polymorphisms (SNPs) finds evidence for opposite associations between different FCN1 haplotypes and clinical leprosy in Euro-Brazilians and Afro-Brazilians. PMID: 22941510
16. Two polymorphisms in the promoter region of FCN1 is associated with the expression and synthesis of ficolin-1 as well as associated with decreased survival in a cohort of patient with systemic inflammatory response syndrome and sepsis. PMID: 22673311
17. M-ficolin concentrations in cord blood are related to circulating phagocytes and to early-onset sepsis PMID: 22391637
18. In patients with haematological malignancy undergoing chemotherapy, those with high MASP-2 were less likely to develop severe infections. PMID: 22236007
19. Data identified the binding interface between CRP and FBG, locating it to the pH- and calcium-sensitive C-terminal region of FBG PMID: 21689722
20. It is postulated that the elevation of concentration of the two components of the leptin pathway, L-ficolin and MASP-2, may compensate for the insufficient activity of the LP in mannose-binding lectin deficiency PMID: 21974696
21. serum levels associate with neutrophil and monocyte counts in blood and bone marrow from children with cancer PMID: 21112665
22. data indicate interaction of M-ficolin with PTX3 arises from its ability to bind sialylated ligands; M-ficolin-PTX3 interaction described represents a novel case of cross-talk between soluble pattern-recognition molecules PMID: 21490156
23. M-ficolin collaborates with its interacting partners (G protein-coupled receptor 43 and C-reactive protein) to initiate, mediate, and regulate the immune response during bacterial infection. PMID: 21037097
24. We suggest that M-ficolin should also be considered as a humoral pattern recognition molecule. PMID: 20375634
25. a novel self-recognition mechanism of leukocytes mediated by the fibrinogen-like domain of Ficolin-1. PMID: 20400674
26. sialic acid binding specificity of M-ficolin, emphasizing the essential role of Tyr(271) in this respect PMID: 20032467
27. Results describe the x-ray structure of human mannan-binding lectin-associated protein 19 (MAp19), and identify the residues involved in the interaction of MAp19 with mannan-binding lectin and L-ficolin. PMID: 15117939
28. M-ficolin is present on the surface of peripheral blood monocytes and binds to acetylated compounds. PMID: 16305643
29. The crystal structure and ligand binding study of human M-ficolin reveal how the three fibrinogen domains form a trimer and provide a structural basis for understanding how ficolins discriminate between self and non-self. PMID: 17148457
30. M-Ficolin expression is silenced in macrophages but can be re-activated after prolonged activation via TLR2 and TLR4 PMID: 17928056
31. This study was conducted to determine mannose-binding lectin (MBL)/MBL-associated serine protease (MASP) complexes and L-ficolin/MASP complexes bind to different strains of group B streptococci to activate the lectin pathway. PMID: 17938215
32. FCN1 GENE POLYMORPHISM IS ASSOCIATED WITH THE DEVELOPMENT OF RHEUMATOID ARTHITIS. PMID: 18032536
33. Ficolin-1 exists in human plasma and serum under normal conditions, hereby revising the general assumption that Ficolin-1 is solely a cellular associated protein. PMID: 18343499
34. Data show that low cord blood M-ficolin was associated with higher NEC-associated fatality and with increased need for mechanical ventilation, and future studies need to assess whether M-ficolin is involved in multiorgan failure and pulmonary disease. PMID: 19539995
35. Ficolin-1 is present in a highly mobilizable subset of human neutrophil granules and associates with the cell surface after stimulation with fMLP. PMID: 19741154
36. CRP binding is enhanced by conformational bending at the neck region of M-ficolin, to avoid steric hindrance by the COL domain. PMID: 19853918

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HGNC: 3623

OMIM: 601252

KEGG: hsa:2219

STRING: 9606.ENSP00000360871

UniGene: Hs.440898