Name: Recombinant Human Follicular dendritic cell secreted peptide(FDCSP)
Brand: CUSABIO
SKU: 854120HU

Product Details

Purity	>85% (SDS-PAGE)
Target Names	FDCSP
Uniprot No.	Q8NFU4
Alternative Names	C4orf7; FDC secreted protein; FDC-SP; FDCSP; FDSCP_HUMAN; Follicular dendritic cell secreted peptide; Follicular dendritic cell secreted protein
Species	Homo sapiens (Human)
Expression Region	18-85
Target Protein Sequence	FPV SQDQEREKRS ISDSDELASG FFVFPYPYPF RPLPPIPFPR FPWFRRNFPI PIPESAPTTP LPSEK
Protein Length	Full Length of Mature Protein
Tag Info	The following tags are available. N-terminal His-tagged Tag-Free The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form	Lyophilized powder
Buffer before Lyophilization	Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution	We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs	Protein FAQs
Storage Condition	Store at -20°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life	The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time	Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time. Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes	Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet	Please contact us to get it.

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Target Background

Function (From Uniprot)	Can bind to the surface of B-lymphoma cells, but not T-lymphoma cells, consistent with a function as a secreted mediator acting upon B-cells.
Gene References into Functions	These studies show that TNF-alpha stimulates human FDC-SP gene transcription by targeting YY1, GATA, C/EBP2 and C/EBP3 in the FDC-SP gene promoter. PMID: 29356241 LPS-induced upregulation of FDC-SP expression in human periodontal ligament cells may enhance osteoclastogenesis in periodontal disease. PMID: 26577469 FDC-SP may be involved in IgA production in the tonsils of Immunoglobulin A nephropathy patients. PMID: 25953661 FDC-SP overexpression inhibits osteogenic differentiation of hPDLCs. study contributes to a better understanding of biological functions governing FDC-SP-induced hPDLC differentiation. PMID: 24138099 Our findings demonstrate that transfection with FDC-SP has negligible adverse effect on proliferation of hPDLCs and imply the biological function of FDC-SP as a fibroblastic phenotype stabilizer PMID: 24357406 The role of C4orf7 in ovarian cancer cell morphology, motility and invasion was demonstrated. PMID: 20811673 FDC-SP has a very restricted tissue distribution, expressed by activated FDCs from tonsils and TNF-alpha-activated FDC-like cell lines, but not by B cell lines, primary germinal center B cells, or anti-CD40 plus IL-4-activated B cells. PMID: 12193705 Since only normal tissue was examined, these findings suggest that FDC-SP plays an important but previously unsuspected role within oral connective tissue. PMID: 16259954 These results provide the first evidence for immunomodulatory activities of FDC-SP and implicate this molecule as a regulator of B cell responses. PMID: 17548624 Show More Hide All
Subcellular Location	Secreted
Tissue Specificity	Abundantly expressed in tonsil, lymph node, and trachea; strong expression in prostate; lower expression in thyroid, stomach, and colon.
Database Links	HGNC: 19215 OMIM: 607241 KEGG: hsa:260436 STRING: 9606.ENSP00000318437 UniGene: Hs.733448

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Code	CSB-YP854120HU
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Code	CSB-EP854120HU-B
Size	Pls inquire
Source	E.coli
Conjugate	Avi-tag Biotinylated E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code	CSB-BP854120HU
Size	Pls inquire
Source	Baculovirus
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Code	CSB-MP854120HU
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Source	Mammalian cell
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Recombinant Human Follicular dendritic cell secreted peptide(FDCSP)

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Target Background

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